Imperial College London
Portrait Picture

DrClemensBrechtelsbauer

Faculty of Engineering, Department of Chemical Engineering

Director Chemical Engineering Education, IC Teaching Fellow
 
 
 
//

Contact

 

+44 (0)20 7594 1662c.brechtelsbauer Website CV

 
 
//

Location

 

206ACE ExtensionSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Schmidt:2004,
author = {Schmidt, B and Patel, J and Ricard, FX and Brechtelsbauer, CM and Lewis, N},
journal = {Organic Process Research and Development},
pages = {998--1008},
title = {Application of Process Modelling Tools in the Scale-Up of Pharmaceutical Crystallisation Processes},
url = {http://pubs.acs.org/doi/pdf/10.1021/op040013n},
volume = {8},
year = {2004}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Crystallisations are frequent process steps in the manufacture of active pharmaceutical ingredients (APIs). They are the primary means of intermediate or product formation andseparation to achieve the desired purity and form. These unit operations are complex processes which are difficult to control due to the interlinked chemical and physical effects. For example, chemical aspects such as salt and polymorph concernsare in the forefront of process research, but physical effects manifesting themselves on scale-up, due to equipment influences, can be equally important for the successful outcome of a campaign. Several operational parameters, such as temperature or impeller speed, need to be understood and controlled to achieve constant desupersaturation, consistent narrow particle size distribution around the desired mean, minimal attrition, and homogeneous growth conditions. This paper focuses on the equipment influence on crystallisations, relating it to first principles with respect to heat and momentum transfer, analysing it with computational fluid dynamics (CFD),and demonstrating its process impact using examples from recent development work. Dynamic process modelling and CFD are state-of-the-art engineering tools to identify process requirements and match them with equipment capabilities. The workreported here demonstrates how a semiquantitative application of these tools can lead to a controllable, robust process in an existing plant despite the time and resource limitations usually encountered in the industry.
AU  - Schmidt,B
AU  - Patel,J
AU  - Ricard,FX
AU  - Brechtelsbauer,CM
AU  - Lewis,N
EP  - 1008
PY  - 2004///
SP  - 998
TI  - Application of Process Modelling Tools in the Scale-Up of Pharmaceutical Crystallisation Processes
T2  - Organic Process Research and Development
UR  - http://pubs.acs.org/doi/pdf/10.1021/op040013n
VL  - 8
ER  -
Download