Imperial College London

Emeritus ProfessorCharlesMichel

Faculty of EngineeringDepartment of Bioengineering

Emeritus Professor
 
 
 
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Contact

 

+44 (0)1481 823 452c.c.michel

 
 
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Location

 

4.29Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

260 results found

Curry FE, Michel CC, 2021, The Colloid Osmotic Pressure Across the Glycocalyx: Role of Interstitial Fluid Sub-Compartments in Trans-Vascular Fluid Exchange in Skeletal Muscle, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, Vol: 9, ISSN: 2296-634X

Journal article

Woodcock TE, Michel CC, 2021, Advances in the Starling Principle and Microvascular Fluid Exchange; Consequences and Implications for Fluid Therapy, FRONTIERS IN VETERINARY SCIENCE, Vol: 8

Journal article

Michel CC, Woodcock TE, Curry F-RE, 2020, Understanding and extending the Starling principle, ACTA ANAESTHESIOLOGICA SCANDINAVICA, Vol: 64, Pages: 1032-1037, ISSN: 0001-5172

Journal article

Desideri S, Onions KL, Butler MJ, Michel CC, Satchell SC, Salmon AHJ, Foster RRet al., 2018, Glomerular permeability changes of albumin in isolated glomeruli do not mimic changes in albumin excretion in vivo in diseased states Reply, KIDNEY INTERNATIONAL, Vol: 94, Pages: 220-220, ISSN: 0085-2538

Journal article

Desideri S, Onions KL, Qiu Y, Ramnath RD, Butler MJ, Neal CR, King MLR, Salmon AE, Saleem MA, Welsh GI, Michel CC, Satchell SC, Salmon AHJ, Foster RRet al., 2018, A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli, KIDNEY INTERNATIONAL, Vol: 93, Pages: 1086-1097, ISSN: 0085-2538

Journal article

Michel CC, 2016, Renal lymph: a window for renal pathophysiology?, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 594, Pages: 1519-1519, ISSN: 0022-3751

Journal article

Michel CC, Nanjee MN, Olszewski WL, Miller NEet al., 2015, LDL and HDL transfer rates across peripheral microvascular endothelium agree with those predicted for passive ultrafiltration in humans, JOURNAL OF LIPID RESEARCH, Vol: 56, Pages: 122-128, ISSN: 0022-2275

Journal article

Kuliga KZ, McDonald EF, Gush R, Michel C, Chipperfield AJ, Clough GFet al., 2014, Dynamics of microvascular blood flow and oxygenation measured simultaneously in human skin., Microcirculation, Vol: 21, Pages: 562-573

OBJECTIVE: To evaluate the dynamics of skin microvascular blood flow (BF) and tissue oxygenation parameters (OXY) measured simultaneously at the same site using a combined non-invasive BF+OXY+temperature probe. METHODS: Skin BF, oxygenated (oxyHb) and deoxygenated (deoxyHb) haemoglobin and mean oxygen saturation (SO2 ) were measured in 50 healthy volunteers at rest and during perturbation of local blood flow by post-occlusive reactive hyperaemia, sympathetic nervous system-mediated vasoconstriction (deep inspiratory breath-hold) and local skin warming. Signals were analysed in time and frequency domains. RESULTS: The relationship between BF and SO2 over the range of flows investigated was described by a non-linear equation with an asymptote for SO2 of 84% at BF >50 PU. SO2 was independently associated with BF, skin temperature, BMI and age, which together identified 59% of the variance in SO2 (p<0.0001). Fourier analysis revealed periodic low frequency fluctuations in both BF and SO2 , attributable to endothelial (~0.01 Hz), neurogenic (~0.04 Hz) and myogenic (~0.1 Hz) flow motion activity. The frequency coherence between the BF and SO2 signals was greatest in the endothelial and neurogenic frequency bands. CONCLUSIONS: The simultaneous evaluation of microvascular blood flow and oxygenation kinetics in healthy skin provides a platform from which to investigate microvascular impairment in the skin and more generally the pathogenesis of microvascular disease.

Journal article

Arkill KP, Qvortrup K, Starborg T, Mantell JM, Knupp C, Michel CC, Harper SJ, Salmon AH, Squire JM, Bates DO, Neal CRet al., 2014, Resolution of the three dimensional structure of components of the glomerular filtration barrier, BMC NEPHROLOGY, Vol: 15, ISSN: 1471-2369

Journal article

Michel CC, 2012, Electron Tomography of Vesicles, MICROCIRCULATION, Vol: 19, Pages: 473-476, ISSN: 1073-9688

Journal article

Lu Y, Michel CC, Wang W, 2012, Inert gas clearance from tissue by co-currently and counter-currently arranged microvessels, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 113, Pages: 487-497, ISSN: 8750-7587

Journal article

Arkill KP, Neal CR, Mantell JM, Michel CC, Qvortrup K, Rostgaard J, Bates DO, Knupp C, Squire JMet al., 2012, 3D Reconstruction of the Glycocalyx Structure in Mammalian Capillaries using Electron Tomography, MICROCIRCULATION, Vol: 19, Pages: 343-351, ISSN: 1073-9688

Journal article

Miller NE, Michel CC, Nanjee MN, Olszewski WL, Miller IP, Hazell M, Olivecrona G, Sutton P, Humphreys SM, Frayn KNet al., 2011, Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 301, Pages: E659-E667, ISSN: 0193-1849

Journal article

Arkill KP, Knupp C, Michel CC, Neal CR, Qvortrup K, Rostgaard J, Squire JMet al., 2011, Similar Endothelial Glycocalyx Structures in Microvessels from a Range of Mammalian Tissues: Evidence for a Common Filtering Mechanism?, BIOPHYSICAL JOURNAL, Vol: 101, Pages: 1046-1056, ISSN: 0006-3495

Journal article

Levick JR, Michel CC, 2010, Microvascular fluid exchange and the revised Starling principle, CARDIOVASCULAR RESEARCH, Vol: 87, Pages: 198-210, ISSN: 0008-6363

Journal article

Michel CC, Curry F-RE, 2009, Glycocalyx volume: a critical review of tracer dilution methods for its measurement, MICROCIRCULATION, Vol: 16, Pages: 213-+, ISSN: 1073-9688

Journal article

Michel CC, Curry F-RE, 2009, Glycocalyx volume measurements: a critical review of tracer dilution methods for its measurement (vol 16, pg 213, 2009), MICROCIRCULATION, Vol: 16, Pages: 544-546, ISSN: 1073-9688

Journal article

Michel CC, 2008, How experiments on single capillaries help us to understand the circulation as a whole, ASIAN BIOMEDICINE, Vol: 2, Pages: 101-115, ISSN: 1905-7415

Journal article

Michel CC, 2007, Exchange of fluid and solutes across microvascular walls, The Kidney, Editors: Alpern, Hebert, San Diego, Publisher: Elsevier, Pages: 275-303

Book chapter

Michel CC, Pappenheimer JR, 2005, Importance of the villus microcirculation for intestinal absorption of glucose, Tokyo, Organ Microcirculation, Publisher: Springer-Verlag, Pages: 3-12

Conference paper

Michel CC, 2005, Transport of Fluid and Solutes in Tissues, Pressure Ulcer Research:Current and Future Perspectives., Editors: Bader, Bouten, Colin, Oomens, Berlin, Heidelberg, New York, Publisher: Springer, Pages: 233-262, ISBN: 978-3-540-25030-2

Book chapter

Michel CC, 2004, Microvascular permeability, ultrafiltration, and restricted diffusion, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 287, Pages: H1887-H1888, ISSN: 0363-6135

Journal article

Michel CC, 2004, Fluid exchange in the microcirculation, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 557, Pages: 701-702, ISSN: 0022-3751

Journal article

Pappenheimer JR, Michel CC, 2003, Role of villus microcirculation in intestinal absorption of glucose: coupling of epithelial with endothelial transport, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 553, Pages: 561-574, ISSN: 0022-3751

Journal article

Romero IA, Radewicz K, Jubin E, Michel CC, Greenwood J, Couraud PO, Adamson Pet al., 2003, Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells, NEUROSCIENCE LETTERS, Vol: 344, Pages: 112-116, ISSN: 0304-3940

Journal article

Wang W, Winlove CP, Michel CC, 2003, Oxygen partial pressure in outer layers of skin of human finger nail folds, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 549, Pages: 855-863, ISSN: 0022-3751

Journal article

Montermini D, Winlove CP, Michel CC, 2002, Effects of perfusion rate on permeability of frog and rat mesenteric microvessels to sodium fluorescein, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 543, Pages: 959-975, ISSN: 0022-3751

Journal article

Clough GF, Boutsiouki P, Church MK, Michel CCet al., 2002, Effects of blood flow on the in vivo recovery of a small diffusible molecule by microdialysis in human skin, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 302, Pages: 681-686, ISSN: 0022-3565

Journal article

Savla U, Neal CR, Michel CC, 2002, Openings in frog microvascular endothelium at different rates of increase in pressure and at different temperatures, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 539, Pages: 285-293, ISSN: 0022-3751

Journal article

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