Imperial College London

Emeritus ProfessorCharlesMichel

Faculty of EngineeringDepartment of Bioengineering

Emeritus Professor
 
 
 
//

Contact

 

+44 (0)1481 823 452c.c.michel

 
 
//

Location

 

4.29Royal School of MinesSouth Kensington Campus

//

Summary

 

Publications

Publication Type
Year
to

260 results found

MICHEL CC, 1977, OSMOTIC REFLECTION COEFFICIENTS OF SINGLE CAPILLARIES TO MYOGLOBIN AND SERUM-ALBUMIN, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 272, Pages: P95-P96, ISSN: 0022-3751

Journal article

Michel CC, Levick JR, 1977, Variations in permeability along individually perfused capillaries of the frog mesentery., Q J Exp Physiol Cogn Med Sci, Vol: 62, Pages: 1-10, ISSN: 0033-5541

When single capillaries in the exposed transilluminated frog mesentery were perfused with solutions containing patent blue V (molecular radius 0-7 nm), unbound T1824 (molecular radius 1-3 nm) and T1824-albumin (molecular radius 3-6 nm), the coloured molecules initially appeared to enter the extracapillary tissues more easily at some places than at others along the length of the vessels. Three patterns of extravascular distribution were observed: (1) High frequency unevenness: patent blue V and unbound T1824 first appeared outside the capillary as spots, bars or bands set at intervals 30-80 mum apart along the length of the vessel. (2) Low frequency unevenness: at later times, the extravascular dye was seen to be unevenly distributed on a much larger scale, with lengths of vessel of up to 400 mum surrounded by little extravascular dye separating similar lengths around which much dye had accummulated. This pattern of distribution was seen for all three solutes. (3) Arteriovenous gradient: perfusions with all three solutes resulted in more extracapillary colouration accumulating around the venous ends of the capillaries. Reasons are given for believing that the distribution of extracapillary solute reflected the distribution of permeability along the length of the capillary. The variations in permeability were attributed to an uneven distribution of small pores along the capillary rather than to presences of large pores.

Journal article

Michel CC, 1977, Reflection coefficients in single capillaries compared with results from whole organs., Bibl Anat, Pages: 172-176, ISSN: 0067-7833

Journal article

Michel CC, 1977, Differences in permeability at different sites of the capillary bed of frog mesentery., Bibl Anat, Pages: 460-462, ISSN: 0067-7833

Journal article

Curry FE, Michel CC, Mason JC, 1976, Osmotic reflextion coefficients of capillary walls to low molecular weight hydrophilic solutes measured in single perfused capillaries of the frog mesentery., J Physiol, Vol: 261, Pages: 319-336, ISSN: 0022-3751

1. Individual capillaries of the transilluminated frog mesentery have been perfused with suspensions of human red cells in frog Ringer solution containing 1-0 g albumin 100 ml.-1. The outer surface of the mesentery has been washed with normal frog Ringer solution and with frog Ringer solutions made hypertonic by addition of one of the following solutes: sodium chloride (100 m-mole. 1.-1); urea (100 m-mole.1.-1); sucrose (20-50 m-mole. 1.-1); cyanocobalamin (8-5 m-mole. 1.-1). The temperature of the mesentery was between 14 and 16 degrees C in all experiments. 2. Wtih the mesentery superfused with normal Ringer, the filtration coefficient was determined from measurements of the rate of fluid filtration across the capillary wall, at a series of known capillary pressures (Michel, Mason, Curry & Tooke, 1974). Filtration coefficient varied from 0-69 X 10(-3) to 4-45 X 10(-3) mum. sec-1 .cm H2O-1 with an average value of 1-87 X 10(-3) mum. sec-1. cm H2O-1. 3. When the superfusate was made hypertonic by the addition of a test solute, the osmotic reflextion coefficient (sigma) of the capillary wall to test solute was calculated from the additional rate of filtration, the concentration of test solute in the superfusate and the filtration coefficient. Average values for sigma were: sodium chloride, 0-068 +/- 0-03 (three capillaries); urea, 0-071 +/- 0.015 (four capillaries); sucrose, 0-115 +/- 0-023 (seven capillaries); cyanocobalamin, 0-100 +/- 0-03 (three capillaries). 4. In further experiments, the osmotic reflextion coefficients to sodium chloride, urea and sucrose were determined in the same capillary. Five technically acceptable experiments were carried out. Although there were differences in the value of sigma between different capillaries, in any one capillary values of sigma were of the same magnitude and there appeared to be no significant trend with the molecular size of the test solute. 5. Our findings are inconsistent with the hypothesis that there is a singl

Journal article

Michel CC, Tasker JA, 1976, Proceedings: Permeability patterns of frog mesenteric capillaries to coloured molecules., J Physiol, Vol: 258, Pages: 112P-113P, ISSN: 0022-3751

Journal article

LOUDON MF, WHITE IF, MICHEL CC, 1976, UPTAKE OF FERRITIN BY ENDOTHELIAL VESICLES, BIORHEOLOGY, Vol: 13, Pages: 258-258, ISSN: 0006-355X

Journal article

MICHEL CC, TASKER JA, 1976, PERMEABILITY PATTERNS OF FROG MESENTERIC CAPILLARIES TO COLORED MOLECULES, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 258, Pages: P112-P113, ISSN: 0022-3751

Journal article

CURRY FE, MASON JC, MICHEL CC, 1976, OSMOTIC REFLECTION COEFFICIENTS OF CAPILLARY WALLS TO LOW-MOLECULAR WEIGHT HYDROPHILIC SOLUTES MEASURED IN SINGLE PERFUSED CAPILLARIES OF FROG MESENTERY, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 261, Pages: 319-336, ISSN: 0022-3751

Journal article

LEVICK JR, MICHEL CC, 1976, CAPILLARY PRESSURES IN FINGERS AND TOES, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 260, Pages: P57-P57, ISSN: 0022-3751

Journal article

LOUDON MF, MICHEL CC, WHITE IF, 1975, SOME OBSERVATIONS UPON RATE OF LABELING OF ENDOTHELIAL VESICLES BY FERRITIN IN FROG MESENTERIC CAPILLARIES, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 252, Pages: P79-P80, ISSN: 0022-3751

Journal article

MICHEL CC, CURRY FE, MASON JC, SHAW TC, TASKER JAet al., 1975, PERMEABILITY AND SELECTIVITY OF CAPILLARIES IN MESENTERY OF FROG, BIBLIOTHECA ANATOMICA, Pages: 6-8, ISSN: 0067-7884

Journal article

Renkin EM, Curry FE, Michel CC, 1974, Failure of histamine, 5-hydroxytryptamine, or bradykinin to increase capillary permeability to plasma proteins in frogs: action of compound 48/80., Microvasc Res, Vol: 8, Pages: 213-217, ISSN: 0026-2862

Journal article

MICHEL CC, 1974, TRANSPORT OF SOLUTE BY OSMOTIC FLOW WITH PARTICULAR REFERENCE TO TRANSPORT OF PROTEIN ACROSS VENOUS FENESTRAE OF VISCERAL CAPILLARIES, MICROVASCULAR RESEARCH, Vol: 8, Pages: 122-124, ISSN: 0026-2862

Journal article

RENKIN EM, CURRY FE, MICHEL CC, 1974, FAILURE OF HISTAMINE,5-HYDROXYTRYPTAMINE, OR BRADYKININ TO INCREASE CAPILLARY-PERMEABILITY TO PLASMA-PROTEINS IN FROGS - ACTION OF COMPOUND 48-80, MICROVASCULAR RESEARCH, Vol: 8, Pages: 213-&, ISSN: 0026-2862

Journal article

CURRY FE, MASON JC, MICHEL CC, 1974, MEASUREMENT IN A SINGLE CAPILLARY OF FILTRATION COEFFICIENT AND PERMEABILITY AND OSMOTIC REFLECTION COEFFICIENT TO SUCROSE, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 241, Pages: P111-P112, ISSN: 0022-3751

Journal article

MICHEL CC, MASON JC, CURRY FE, TOOKE JEet al., 1974, DEVELOPMENT OF LANDIS TECHNIQUE FOR MEASURING FILTRATION COEFFICIENT OF INDIVIDUAL CAPILLARIES IN FROG MESENTERY, QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, Vol: 59, Pages: 283-309, ISSN: 0033-5541

Journal article

Curry FE, Mason JC, Michel CC, 1973, Proceedings: The development of a method of measuring the filtration coefficient of individually perfused frog mesenteric capillaries., J Physiol, Vol: 234, Pages: 26P-27P, ISSN: 0022-3751

Journal article

Curry FE, Mason JC, Michel CC, White IFet al., 1973, Proceedings: A method for investigating the ultrastructure of a single capillary of known permeability properties., J Physiol, Vol: 234, Pages: 24P-25P, ISSN: 0022-3751

Journal article

Michel CC, Snow GR, Tasker JA, 1973, Proceedings: A method for measuring the permeability of individually perfused capillaries of the frog mesentery to coloured molecules., J Physiol, Vol: 234, Pages: 25P-26P, ISSN: 0022-3751

Journal article

Curry FE, Mason JC, Michel CC, 1973, Proceedings: The effect of bovine gamma-globulin and Ca2+ on the filtration coefficient of individual frog mesenteric capillaries., J Physiol, Vol: 234, Pages: 43P-44P, ISSN: 0022-3751

Journal article

Mason JC, Michel CC, Tooke JE, 1973, The effect of plasma proteins and capillary pressure upon the filtration coefficient of frog mesenteric capillaries., J Physiol, Vol: 229, Pages: 15P-16P, ISSN: 0022-3751

Journal article

LEVICK JR, MICHEL CC, 1973, EFFECT OF BOVINE ALBUMIN ON PERMEABILITY OF FROG MESENTERIC CAPILLARIES, QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, Vol: 58, Pages: 87-&, ISSN: 0033-5541

Journal article

LEVICK JR, MICHEL CC, 1973, PERMEABILITY OF INDIVIDUALLY PERFUSED FROG MESENTERIC CAPILLARIES TO T1824 AND T1824-ALBUMIN AS EVIDENCE FOR A LARGE PORE SYSTEM, QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, Vol: 58, Pages: 67-+, ISSN: 0033-5541

Journal article

CURRY FE, MASON JC, MICHEL CC, 1973, EFFECT OF BOVINE GAMMA-GLOBULIN AND CA2+ ON FILTRATION COEFFICIENT OF INDIVIDUAL FROG MESENTERIC CAPILLARIES, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 234, Pages: P43-P44, ISSN: 0022-3751

Journal article

CURRY FE, MASON JC, MICHEL CC, WHITE IFet al., 1973, METHOD FOR INVESTIGATING ULTRASTRUCTURE OF A SINGLE CAPILLARY OF KNOWN PERMEABILITY PROPERTIES, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 234, Pages: P24-P25, ISSN: 0022-3751

Journal article

RENKIN EM, CURRY RC, MICHEL CC, 1973, INFLUENCE OF COMPOUND 48/80 ON MICROVASCULAR PERMEABILITY TO PLASMA-PROTEIN IN FROG, MICROVASCULAR RESEARCH, Vol: 6, Pages: 126-126, ISSN: 0026-2862

Journal article

MICHEL CC, SNOW GR, TASKER JA, 1973, METHOD FOR MEASURING PERMEABILITY OF INDIVIDUALLY PERFUSED CAPILLARIES OF FROG MESENTERY TO COLORED MOLECULES, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 234, Pages: P25-P26, ISSN: 0022-3751

Journal article

MASON JC, MICHEL CC, TOOKE JE, 1973, EFFECT OF PLASMA-PROTEINS AND CAPILLARY PRESSURE UPON FILTRATION COEFFICIENT OF FROG MESENTERIC CAPILLARIES, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 229, Pages: P15-&, ISSN: 0022-3751

Journal article

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: id=00103814&limit=30&person=true&page=8&respub-action=search.html