Chris Chiu is a Clinical Reader and Honorary Consultant in Infectious Diseases. He underwent his basic medical training at Cambridge and Oxford Universities, and later was awarded a Wellcome Trust Clinical Research Training fellowship to undertake a PhD with Charles Bangham and Margaret Callan initially at the Weatherall Institute of Molecular Medicine and then at Imperial College London, investigating transcriptional programming of the early CD8 T cell response to acute viral infection. On completion of his specialist clinical training, he was awarded an MRC Clinician Scientist fellowship and furthered his research by working with Rafi Ahmed's group at Emory University, examining antibody, B cell and T cell responses to influenza and varicella zoster virus vaccines.
His research interests focus on pathogenesis and human protective immunity in respiratory viral infections, including respiratory syncytial virus (RSV), influenza and SARS-CoV-2. These are some of the most important causes of severe disease worldwide and there is an urgent need for effective vaccines against these pathogens. He is an expert in human infection challenge studies and leads a group that uses experimental infection and vaccination of volunteers as well as patient-centred research to investigate systemic and mucosal imImunity against these infections. These highly specialised methods provide a unique opportunity to examine correlates and mechanisms of protection and disease severity in human beings. The work encompasses early phase clinical vaccine trials as well as fundamental studies of human immunity, which together enhance our understanding of how respiratory viral illnesses may be prevented and accelerate the development of better vaccines.
Dr Chiu heads the Imperial Network for Vaccine Research, which brings together investigators from across all faculties with an interest in vaccines, and is Scientific and Research Officer of the British Infection Association. His group is part of a number of international consortia, including the NIAID CIVICs programme and European Union IMI projects, and welcomes collaboration with researchers (both industry and academic) who wish to work together to pursue their shared interests.
et al., 2020, Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection., Science, Vol:370
et al., 2020, Epitope-specific airway-resident CD4+ T-cell dynamics during experimental human RSV infection, Journal of Clinical Investigation, Vol:130, ISSN:0021-9738, Pages:523-538
et al., 2019, Local and systemic immunity against RSV induced by a novel intranasal vaccine: A randomised, double- blind, placebo-controlled trial, American Journal of Respiratory and Critical Care Medicine, Vol:200, ISSN:1073-449X, Pages:481-492
et al., 2018, A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection, Nature Communications, Vol:9, ISSN:2041-1723, Pages:1-11
Ascough SC, Paterson S, Chiu C, 2018, Induction and subversion of human protective immunity: contrasting influenza and respiratory syncytial virus, Frontiers in Immunology, Vol:9, ISSN:1664-3224
Habibi MS, Chiu C, 2016, Controlled human infection with RSV: the opportunities of experimental challenge, Vaccine, Vol:35, ISSN:1873-2518, Pages:489-495
et al., 2015, RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection, Nature Communications, Vol:6, ISSN:2041-1723
et al., 2015, Impaired antibody-mediated protection and defective IgA B cell memory in experimental infection of adults with respiratory syncytial virus, American Journal of Respiratory and Critical Care Medicine, Vol:191, ISSN:1535-4970
Chiu C, Openshaw PJ, 2015, Antiviral B cell and T cell immunity in the lungs, Nature Immunology, Vol:16, ISSN:1529-2908, Pages:18-26
et al., 2014, Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans, Proceedings of the National Academy of Sciences of the United States of America, Vol:111, ISSN:0027-8424, Pages:13133-13138
et al., 2014, Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV, PLOS Pathogens, Vol:10, ISSN:1553-7366, Pages:1-12
et al., 2012, Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells., Proc Natl Acad Sci U S A, Vol:109, Pages:9047-9052
et al., 2007, Early acquisition of cytolytic function and transcriptional changes in a primary CD8(+) T-cell response in vivo, Blood, Vol:109, ISSN:0006-4971, Pages:1086-1094