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@article{Fourati:2018:10.1038/s41467-018-06735-8,
author = {Fourati, S and Taa, A and Mahmoudian, M and Burkhart, JG and Klen, R and Henao, R and Yu, T and Aydin, Z and Yeung, KY and Ahsen, ME and Almugbel, R and Jahandideh, S and Liang, X and Nordling, TEM and Shiga, M and Stanescu, A and Vogel, R and Pandey, G and Chiu, C and McClain, MT and Woods, CW and Ginsburg, GS and Elo, LL and Tsalik, EL and Mangravite, LM and Sieberts, SK},
doi = {10.1038/s41467-018-06735-8},
journal = {Nature Communications},
pages = {1--11},
title = {A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection},
url = {http://dx.doi.org/10.1038/s41467-018-06735-8},
volume = {9},
year = {2018}
}

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TY  - JOUR
AB  - The response to respiratory viruses varies substantially between individuals, and there are currently no known molecular predictors from the early stages of infection. Here we conduct a community-based analysis to determine whether pre- or early post-exposure molecular factors could predict physiologic responses to viral exposure. Using peripheral blood gene expression profiles collected from healthy subjects prior to exposure to one of four respiratory viruses (H1N1, H3N2, Rhinovirus, and RSV), as well as up to 24 h following exposure, we find that it is possible to construct models predictive of symptomatic response using profiles even prior to viral exposure. Analysis of predictive gene features reveal little overlap among models; however, in aggregate, these genes are enriched for common pathways. Heme metabolism, the most significantly enriched pathway, is associated with a higher risk of developing symptoms following viral exposure. This study demonstrates that pre-exposure molecular predictors can be identified and improves our understanding of the mechanisms of response to respiratory viruses.
AU  - Fourati,S
AU  - Taa,A
AU  - Mahmoudian,M
AU  - Burkhart,JG
AU  - Klen,R
AU  - Henao,R
AU  - Yu,T
AU  - Aydin,Z
AU  - Yeung,KY
AU  - Ahsen,ME
AU  - Almugbel,R
AU  - Jahandideh,S
AU  - Liang,X
AU  - Nordling,TEM
AU  - Shiga,M
AU  - Stanescu,A
AU  - Vogel,R
AU  - Pandey,G
AU  - Chiu,C
AU  - McClain,MT
AU  - Woods,CW
AU  - Ginsburg,GS
AU  - Elo,LL
AU  - Tsalik,EL
AU  - Mangravite,LM
AU  - Sieberts,SK
DO  - 10.1038/s41467-018-06735-8
EP  - 11
PY  - 2018///
SN  - 2041-1723
SP  - 1
TI  - A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-018-06735-8
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000448104800007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41467-018-06735-8
UR  - http://hdl.handle.net/10044/1/82348
VL  - 9
ER  -

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