Imperial College London
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ProfessorChristopherChiu

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 3313 2301c.chiu Website

 
 
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Location

 

8N.15Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Thwaites:2021:10.1126/sciimmunol.abg9873,
author = {Thwaites, RS and Sanchez, Sevilla Uruchurtu A and Siggins, MK and Liew, F and Russell, CD and Moore, SC and Fairfield, C and Carter, E and Abrams, S and Short, C and Thaventhiran, T and Bergstrom, E and Gardener, Z and Ascough, S and Chiu, C and Docherty, AB and Hunt, D and Crow, YJ and Solomon, T and Taylor, GP and Turtle, L and Harrison, EM and Dunning, J and Semple, MG and Baillie, JK and Openshaw, PJM},
doi = {10.1126/sciimmunol.abg9873},
journal = {Science Immunology},
pages = {1--17},
title = {Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19},
url = {http://dx.doi.org/10.1126/sciimmunol.abg9873},
volume = {6},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from other viral lung diseases remain poorly characterized. We analyzed plasma samples from 471 hospitalized patients recruited through the prospective multicenter ISARIC4C study and 39 outpatients with mild disease, enabling extensive characterization of responses across a full spectrum of COVID-19 severity. Progressive elevation of levels of numerous inflammatory cytokines and chemokines (including IL-6, CXCL10, and GM-CSF) were associated with severity and accompanied by elevated markers of endothelial injury and thrombosis. Principal component and network analyses demonstrated central roles for IL-6 and GM-CSF in COVID-19 pathogenesis. Comparing these profiles to archived samples from patients with fatal influenza, IL-6 was equally elevated in both conditions whereas GM-CSF was prominent only in COVID-19. These findings further identify the key inflammatory, thrombotic, and vascular factors that characterize and distinguish severe and fatal COVID-19.
AU  - Thwaites,RS
AU  - Sanchez,Sevilla Uruchurtu A
AU  - Siggins,MK
AU  - Liew,F
AU  - Russell,CD
AU  - Moore,SC
AU  - Fairfield,C
AU  - Carter,E
AU  - Abrams,S
AU  - Short,C
AU  - Thaventhiran,T
AU  - Bergstrom,E
AU  - Gardener,Z
AU  - Ascough,S
AU  - Chiu,C
AU  - Docherty,AB
AU  - Hunt,D
AU  - Crow,YJ
AU  - Solomon,T
AU  - Taylor,GP
AU  - Turtle,L
AU  - Harrison,EM
AU  - Dunning,J
AU  - Semple,MG
AU  - Baillie,JK
AU  - Openshaw,PJM
DO  - 10.1126/sciimmunol.abg9873
EP  - 17
PY  - 2021///
SN  - 2470-9468
SP  - 1
TI  - Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19
T2  - Science Immunology
UR  - http://dx.doi.org/10.1126/sciimmunol.abg9873
UR  - http://immunology.sciencemag.org/content/6/57/eabg9873.abstract
UR  - https://immunology.sciencemag.org/content/6/57/eabg9873
UR  - http://hdl.handle.net/10044/1/86398
VL  - 6
ER  -
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