Imperial College London
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ProfessorChristopherChiu

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 3313 2301c.chiu Website

 
 
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Location

 

8N.15Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Felt:2021:10.1038/s41564-021-00882-3,
author = {Felt, SA and Sun, Y and Jozwik, A and Paras, A and Habibi, MS and Nickle, D and Anderson, L and Achouri, E and Feemster, KA and Cardenas, AM and Turi, KN and Chang, M and Hartert, TV and Sengupta, S and Chiu, C and Lopez, CB},
doi = {10.1038/s41564-021-00882-3},
journal = {Nature Microbiology},
pages = {672--681},
title = {Detection of respiratory syncytial virus defective genomes in nasal secretions is associated with distinct clinical outcomes},
url = {http://dx.doi.org/10.1038/s41564-021-00882-3},
volume = {6},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Respiratory syncytial virus (RSV) causes respiratory illness in children, immunosuppressed individuals and the elderly. However, the viral factors influencing the clinical outcome of RSV infections remain poorly defined. Defective viral genomes (DVGs) can suppress virus replication by competing for viral proteins and by stimulating antiviral immunity. We studied the association between detection of DVGs of the copy-back type and disease severity in three RSV A-confirmed cohorts. In hospitalized children, detection of DVGs in respiratory samples at or around the time of admission associated strongly with more severe disease, higher viral load and a stronger pro-inflammatory response. Interestingly, in experimentally infected adults, the presence of DVGs in respiratory secretions differentially associated with RSV disease severity depending on when DVGs were detected. Detection of DVGs early after infection associated with low viral loads and mild disease, whereas detection of DVGs late after infection, especially if DVGs were present for prolonged periods, associated with high viral loads and severe disease. Taken together, we demonstrate that the kinetics of DVG accumulation and duration could predict clinical outcome of RSV A infection in humans, and thus could be used as a prognostic tool to identify patients at risk of worse clinical disease.
AU  - Felt,SA
AU  - Sun,Y
AU  - Jozwik,A
AU  - Paras,A
AU  - Habibi,MS
AU  - Nickle,D
AU  - Anderson,L
AU  - Achouri,E
AU  - Feemster,KA
AU  - Cardenas,AM
AU  - Turi,KN
AU  - Chang,M
AU  - Hartert,TV
AU  - Sengupta,S
AU  - Chiu,C
AU  - Lopez,CB
DO  - 10.1038/s41564-021-00882-3
EP  - 681
PY  - 2021///
SN  - 2058-5276
SP  - 672
TI  - Detection of respiratory syncytial virus defective genomes in nasal secretions is associated with distinct clinical outcomes
T2  - Nature Microbiology
UR  - http://dx.doi.org/10.1038/s41564-021-00882-3
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000635848900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41564-021-00882-3
UR  - http://hdl.handle.net/10044/1/91402
VL  - 6
ER  -
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