Imperial College London
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ProfessorChristopherChiu

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 3313 2301c.chiu Website

 
 
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Location

 

8N.15Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ascough:2018:10.3389/fimmu.2018.00323,
author = {Ascough, SC and Paterson, S and Chiu, C},
doi = {10.3389/fimmu.2018.00323},
journal = {Frontiers in Immunology},
title = {Induction and subversion of human protective immunity: contrasting influenza and respiratory syncytial virus},
url = {http://dx.doi.org/10.3389/fimmu.2018.00323},
volume = {9},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Respiratory syncytial virus (RSV) and influenza are among the most important causes of severe respiratory disease worldwide. Despite the clinical need, barriers to developing reliably effective vaccines against these viruses have remained firmly in place for decades. Overcoming these hurdles requires better understanding of human immunity and the strategies by which these pathogens evade it. Although superficially similar, the virology and host response to RSV and influenza are strikingly distinct. Influenza induces robust strain-specific immunity following natural infection, although protection by current vaccines is short-lived. In contrast, even strain-specific protection is incomplete after RSV and there are currently no licensed RSV vaccines. Although animal models have been critical for developing a fundamental understanding of antiviral immunity, extrapolating to human disease has been problematic. It is only with recent translational advances (such as controlled human infection models and high-dimensional technologies) that the mechanisms responsible for differences in protection against RSV compared to influenza have begun to be elucidated in the human context. Influenza infection elicits high-affinity IgA in the respiratory tract and virus-specific IgG, which correlates with protection. Long-lived influenza-specific T cells have also been shown to ameliorate disease. This robust immunity promotes rapid emergence of antigenic variants leading to immune escape. RSV differs markedly, as reinfection with similar strains occurs despite natural infection inducing high levels of antibody against conserved antigens. The immunomodulatory mechanisms of RSV are thus highly effective in inhibiting long-term protection, with disturbance of type I interferon signaling, antigen presentation and chemokine-induced inflammation possibly all contributing. These lead to widespread effects on adaptive immunity with impaired B cell memory and reduced T cell generation and funct
AU  - Ascough,SC
AU  - Paterson,S
AU  - Chiu,C
DO  - 10.3389/fimmu.2018.00323
PY  - 2018///
SN  - 1664-3224
TI  - Induction and subversion of human protective immunity: contrasting influenza and respiratory syncytial virus
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2018.00323
UR  - http://hdl.handle.net/10044/1/57690
VL  - 9
ER  -
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