Imperial College London
Alternate

Professor Claudia Clopath

Faculty of Engineering, Department of Bioengineering

Professor of Computational Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 1435c.clopath Website

 
 
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Location

 

Royal School of Mines 4.09Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Knopfel:2019:10.1038/s41467-019-13607-2,
author = {Knopfel, T and Sweeney, Y and Radulescu, CI and Zabouri, N and Doostdar, N and Clopath, C and Barnes, S},
doi = {10.1038/s41467-019-13607-2},
journal = {Nature Communications},
title = {Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex},
url = {http://dx.doi.org/10.1038/s41467-019-13607-2},
volume = {10},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We experience the world through multiple senses simultaneously. To better understand mechanisms of multisensory processing we ask whether inputs from two senses (auditory and visual) can interact and drive plasticity in neural-circuits of the primary visual cortex (V1). Using genetically-encoded voltage and calcium indicators, we find coincident audio-visual experience modifies both the supra and subthreshold response properties of neurons in L2/3 of mouse V1. Specifically, we find that after audio-visual pairing, a subset of multimodal neurons develops enhanced auditory responses to the paired auditory stimulus. This cross-modal plasticity persists over days and is reflected in the strengthening of small functional networks of L2/3 neurons. We find V1 processes coincident auditory and visual events by strengthening functional associations between feature specific assemblies of multimodal neurons during bouts of sensory driven co-activity, leaving a trace of multisensory experience in the cortical network.
AU  - Knopfel,T
AU  - Sweeney,Y
AU  - Radulescu,CI
AU  - Zabouri,N
AU  - Doostdar,N
AU  - Clopath,C
AU  - Barnes,S
DO  - 10.1038/s41467-019-13607-2
PY  - 2019///
SN  - 2041-1723
TI  - Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-019-13607-2
UR  - http://hdl.handle.net/10044/1/75223
VL  - 10
ER  -
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