Imperial College London
Alternate

Professor Claudia Clopath

Faculty of Engineering, Department of Bioengineering

Professor of Computational Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 1435c.clopath Website

 
 
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Location

 

Royal School of Mines 4.09Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Udakis:2020:10.1038/s41467-020-18074-8,
author = {Udakis, M and Pedrosa, V and Chamberlain, SEL and Clopath, C and Mellor, JR},
doi = {10.1038/s41467-020-18074-8},
journal = {Nature Communications},
pages = {4395--4395},
title = {Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output},
url = {http://dx.doi.org/10.1038/s41467-020-18074-8},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The formation and maintenance of spatial representations within hippocampal cell assemblies is strongly dictated by patterns of inhibition from diverse interneuron populations. Although it is known that inhibitory synaptic strength is malleable, induction of long-term plasticity at distinct inhibitory synapses and its regulation of hippocampal network activity is not well understood. Here, we show that inhibitory synapses from parvalbumin and somatostatin expressing interneurons undergo long-term depression and potentiation respectively (PV-iLTD and SST-iLTP) during physiological activity patterns. Both forms of plasticity rely on T-type calcium channel activation to confer synapse specificity but otherwise employ distinct mechanisms. Since parvalbumin and somatostatin interneurons preferentially target perisomatic and distal dendritic regions respectively of CA1 pyramidal cells, PV-iLTD and SST-iLTP coordinate a reprioritisation of excitatory inputs from entorhinal cortex and CA3. Furthermore, circuit-level modelling reveals that PV-iLTD and SST-iLTP cooperate to stabilise place cells while facilitating representation of multiple unique environments within the hippocampal network.
AU  - Udakis,M
AU  - Pedrosa,V
AU  - Chamberlain,SEL
AU  - Clopath,C
AU  - Mellor,JR
DO  - 10.1038/s41467-020-18074-8
EP  - 4395
PY  - 2020///
SN  - 2041-1723
SP  - 4395
TI  - Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-020-18074-8
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32879322
UR  - https://www.nature.com/articles/s41467-020-18074-8
UR  - http://hdl.handle.net/10044/1/83584
VL  - 11
ER  -
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