Imperial College London
Alternate

Professor Claudia Clopath

Faculty of Engineering, Department of Bioengineering

Professor of Computational Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 1435c.clopath Website

 
 
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Location

 

Royal School of Mines 4.09Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ang:2021:10.1371/journal.pcbi.1009017,
author = {Ang, GWY and Tang, CS and Hay, YA and Zannone, S and Paulsen, O and Clopath, C},
doi = {10.1371/journal.pcbi.1009017},
journal = {PLoS Computational Biology},
pages = {1--22},
title = {The functional role of sequentially neuromodulated synaptic plasticity in behavioural learning},
url = {http://dx.doi.org/10.1371/journal.pcbi.1009017},
volume = {17},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - To survive, animals have to quickly modify their behaviour when the reward changes. The internal representations responsible for this are updated through synaptic weight changes, mediated by certain neuromodulators conveying feedback from the environment. In previous experiments, we discovered a form of hippocampal Spike-Timing-Dependent-Plasticity (STDP) that is sequentially modulated by acetylcholine and dopamine. Acetylcholine facilitates synaptic depression, while dopamine retroactively converts the depression into potentiation. When these experimental findings were implemented as a learning rule in a computational model, our simulations showed that cholinergic-facilitated depression is important for reversal learning. In the present study, we tested the model’s prediction by optogenetically inactivating cholinergic neurons in mice during a hippocampus-dependent spatial learning task with changing rewards. We found that reversal learning, but not initial place learning, was impaired, verifying our computational prediction that acetylcholine-modulated plasticity promotes the unlearning of old reward locations. Further, differences in neuromodulator concentrations in the model captured mouse-by-mouse performance variability in the optogenetic experiments. Our line of work sheds light on how neuromodulators enable the learning of new contingencies.
AU  - Ang,GWY
AU  - Tang,CS
AU  - Hay,YA
AU  - Zannone,S
AU  - Paulsen,O
AU  - Clopath,C
DO  - 10.1371/journal.pcbi.1009017
EP  - 22
PY  - 2021///
SN  - 1553-734X
SP  - 1
TI  - The functional role of sequentially neuromodulated synaptic plasticity in behavioural learning
T2  - PLoS Computational Biology
UR  - http://dx.doi.org/10.1371/journal.pcbi.1009017
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000664330700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009017
UR  - http://hdl.handle.net/10044/1/91393
VL  - 17
ER  -
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