Imperial College London
Alternate

Professor Claudia Clopath

Faculty of Engineering, Department of Bioengineering

Professor of Computational Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 1435c.clopath Website

 
 
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Location

 

Royal School of Mines 4.09Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Prince:2021:10.1371/journal.pcbi.1009435,
author = {Prince, LY and Bacon, T and Humphries, R and Tsaneva-Atanasova, K and Clopath, C and Mellor, JR},
doi = {10.1371/journal.pcbi.1009435},
journal = {PLoS Computational Biology},
pages = {1--37},
title = {Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits},
url = {http://dx.doi.org/10.1371/journal.pcbi.1009435},
volume = {17},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In the hippocampus, episodic memories are thought to be encoded by the formation of ensembles of synaptically coupled CA3 pyramidal cells driven by sparse but powerful mossy fiber inputs from dentate gyrus granule cells. The neuromodulators acetylcholine and noradrenaline are separately proposed as saliency signals that dictate memory encoding but it is not known if they represent distinct signals with separate mechanisms. Here, we show experimentally that acetylcholine, and to a lesser extent noradrenaline, suppress feed-forward inhibition and enhance Excitatory–Inhibitory ratio in the mossy fiber pathway but CA3 recurrent network properties are only altered by acetylcholine. We explore the implications of these findings on CA3 ensemble formation using a hierarchy of models. In reconstructions of CA3 pyramidal cells, mossy fiber pathway disinhibition facilitates postsynaptic dendritic depolarization known to be required for synaptic plasticity at CA3-CA3 recurrent synapses. We further show in a spiking neural network model of CA3 how acetylcholine-specific network alterations can drive rapid overlapping ensemble formation. Thus, through these distinct sets of mechanisms, acetylcholine and noradrenaline facilitate the formation of neuronal ensembles in CA3 that encode salient episodic memories in the hippocampus but acetylcholine selectively enhances the density of memory storage.
AU  - Prince,LY
AU  - Bacon,T
AU  - Humphries,R
AU  - Tsaneva-Atanasova,K
AU  - Clopath,C
AU  - Mellor,JR
DO  - 10.1371/journal.pcbi.1009435
EP  - 37
PY  - 2021///
SN  - 1553-734X
SP  - 1
TI  - Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits
T2  - PLoS Computational Biology
UR  - http://dx.doi.org/10.1371/journal.pcbi.1009435
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000702908500002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009435
UR  - http://hdl.handle.net/10044/1/92994
VL  - 17
ER  -
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