Imperial College London
Alternate

Professor Claudia Clopath

Faculty of Engineering, Department of Bioengineering

Professor of Computational Neuroscience
 
 
 
//

Contact

 

+44 (0)20 7594 1435c.clopath Website

 
 
//

Location

 

Royal School of Mines 4.09Royal School of MinesSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Geiller:2021:10.1038/s41586-021-04169-9,
author = {Geiller, T and Sadeh, S and Clopath, C and Losonczy, A},
doi = {10.1038/s41586-021-04169-9},
journal = {Nature},
pages = {105--109},
title = {Local circuit amplification of spatial selectivity in the hippocampus},
url = {http://dx.doi.org/10.1038/s41586-021-04169-9},
volume = {601},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Local circuit architecture facilitates the emergence of feature selectivity in the cerebral cortex1. In the hippocampus, it remains unknown whether local computations supported by specific connectivity motifs2 regulate the spatial receptive fields of pyramidal cells3. Here we developed an in vivo electroporation method for monosynaptic retrograde tracing4 and optogenetics manipulation at single-cell resolution to interrogate the dynamic interaction of place cells with their microcircuitry during navigation. We found a local circuit mechanism in CA1 whereby the spatial tuning of an individual place cell can propagate to a functionally recurrent subnetwork5 to which it belongs. The emergence of place fields in individual neurons led to the development of inverse selectivity in a subset of their presynaptic interneurons, and recruited functionally coupled place cells at that location. Thus, the spatial selectivity of single CA1 neurons is amplified through local circuit plasticity to enable effective multi-neuronal representations that can flexibly scale environmental features locally without degrading the feedforward input structure.
AU  - Geiller,T
AU  - Sadeh,S
AU  - Clopath,C
AU  - Losonczy,A
DO  - 10.1038/s41586-021-04169-9
EP  - 109
PY  - 2021///
SN  - 0028-0836
SP  - 105
TI  - Local circuit amplification of spatial selectivity in the hippocampus
T2  - Nature
UR  - http://dx.doi.org/10.1038/s41586-021-04169-9
UR  - https://www.nature.com/articles/s41586-021-04169-9
UR  - http://hdl.handle.net/10044/1/93316
VL  - 601
ER  -
Download