Imperial College London
Alternate

Professor Claudia Clopath

Faculty of Engineering, Department of Bioengineering

Professor of Computational Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 1435c.clopath Website

 
 
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Location

 

Royal School of Mines 4.09Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Poort:2022:10.1016/j.neuron.2021.11.016,
author = {Poort, J and Wilmes, KA and Blot, A and Chadwick, A and Sahani, M and Clopath, C and Mrsic-Flogel, TD and Hofer, SB and Khan, AG},
doi = {10.1016/j.neuron.2021.11.016},
journal = {Neuron},
pages = {689--697.e6},
title = {Learning and attention increase visual response selectivity through distinct mechanisms.},
url = {http://dx.doi.org/10.1016/j.neuron.2021.11.016},
volume = {110},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Selectivity of cortical neurons for sensory stimuli can increase across days as animals learn their behavioral relevance and across seconds when animals switch attention. While both phenomena occur in the same circuit, it is unknown whether they rely on similar mechanisms. We imaged primary visual cortex as mice learned a visual discrimination task and subsequently performed an attention switching task. Selectivity changes due to learning and attention were uncorrelated in individual neurons. Selectivity increases after learning mainly arose from selective suppression of responses to one of the stimuli but from selective enhancement and suppression during attention. Learning and attention differentially affected interactions between excitatory and PV, SOM, and VIP inhibitory cells. Circuit modeling revealed that cell class-specific top-down inputs best explained attentional modulation, while reorganization of local functional connectivity accounted for learning-related changes. Thus, distinct mechanisms underlie increased discriminability of relevant sensory stimuli across longer and shorter timescales.
AU  - Poort,J
AU  - Wilmes,KA
AU  - Blot,A
AU  - Chadwick,A
AU  - Sahani,M
AU  - Clopath,C
AU  - Mrsic-Flogel,TD
AU  - Hofer,SB
AU  - Khan,AG
DO  - 10.1016/j.neuron.2021.11.016
EP  - 697
PY  - 2022///
SN  - 0896-6273
SP  - 689
TI  - Learning and attention increase visual response selectivity through distinct mechanisms.
T2  - Neuron
UR  - http://dx.doi.org/10.1016/j.neuron.2021.11.016
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34906356
UR  - https://www.sciencedirect.com/science/article/pii/S0896627321009545?via%3Dihub
UR  - http://hdl.handle.net/10044/1/93319
VL  - 110
ER  -
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