Imperial College London


Faculty of Natural SciencesDepartment of Mathematics

Visiting Professor



+44 (0)20 7594 2647c.colijn Website




626Huxley BuildingSouth Kensington Campus






BibTex format

author = {Hatherell, H-A and Didelot, X and Pollock, SL and Tang, P and Crisan, A and Johnston, JC and Colijn, C and Gardy, J},
doi = {10.1099/mgen.0.000060},
journal = {Microbial Genomics},
pages = {10.1099/mgen.0.000060--10.1099/mgen.0.000060},
title = {Declaring a tuberculosis outbreak over with genomic epidemiology},
url = {},
volume = {2},
year = {2016}

RIS format (EndNote, RefMan)

AB - We report an updated method for inferring the time at which an infectious disease was transmitted between persons from a time-labelled pathogen genome phylogeny. We applied the method to 48 Mycobacterium tuberculosis genomes as part of a real-time public health outbreak investigation, demonstrating that although active tuberculosis (TB) cases were diagnosed through 2013, no transmission events took place beyond mid-2012. Subsequent cases were the result of progression from latent TB infection to active disease and not recent transmission. This evolutionary genomic approach was used to declare the outbreak over in January 2015.
AU - Hatherell,H-A
AU - Didelot,X
AU - Pollock,SL
AU - Tang,P
AU - Crisan,A
AU - Johnston,JC
AU - Colijn,C
AU - Gardy,J
DO - 10.1099/mgen.0.000060
EP - 1099
PY - 2016///
SN - 2057-5858
SP - 10
TI - Declaring a tuberculosis outbreak over with genomic epidemiology
T2 - Microbial Genomics
UR -
UR -
VL - 2
ER -