Publications
976 results found
COOMBES RC, NEVILLE AM, BONDY PK, et al., 1976, FAILURE OF INDOMETHACIN TO REDUCE HYDROXYPROLINE EXCRETION OR HYPERCALCEMIA IN PATIENTS WITH BREAST-CANCER, PROSTAGLANDINS, Vol: 12, Pages: 1027-1035, ISSN: 0090-6980
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- Citations: 45
COOMBES RC, WARD MK, GREENBERG PB, et al., 1976, CALCIUM-METABOLISM IN CANCER - STUDIES USING CALCIUM ISOTOPES AND IMMUNOASSAYS FOR PARATHYROID-HORMONE AND CALCITONIN, CANCER, Vol: 38, Pages: 2111-2120, ISSN: 0008-543X
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- Citations: 62
HILLYARD CJ, COOMBES RC, GREENBERG PB, et al., 1976, CALCITONIN IN BREAST AND LUNG-CANCER, CLINICAL ENDOCRINOLOGY, Vol: 5, Pages: 1-8, ISSN: 0300-0664
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- Citations: 58
Ellison ML, Hillyard CJ, Bloomfield GA, et al., 1976, Ectopic hormone production by bronchial carcinomas in culture., Clin Endocrinol (Oxf), Vol: 5 Suppl, Pages: 397S-406S, ISSN: 0300-0664
Monolayer tissue culture has been used as a system in which to study aspects of ectopic hormone secretion. Of a series of twenty-four human bronchial carcinomas, nineteen were successfully established in culture and the supernatant medium from each tested for peptide hormones by radioimmunoassay. Six tumours were found to produce adrenocorticotrophin (ACTH), four to release calcitonin (CT) and one to release both of these hormones. No growth hormone or insulin was detected throughout the series. Net in vitro synthesis of both ACTH and CT was demonstrated by recovery of more hormone during culture than was originally contained in the explanted tumour tissue. The production of hormone by four out of six proliferative cultures established, and its persistence through many subculture passages, confirms ectopic hormone production as a stable heritable characteristic of some lung tumours. The ability of hormone-producing bronchial tumour cells to respond to factors known to influence hormone output from normal endocrine cells was tested. ACTH release was stimulated in one tumour by Pitressin and CT in another by gastrin. In addition, the release of CT from the same tumour cell line was shown to be inhibited by the accumulation of high external concentrations of CT as has been reported for normal C-cells.
Coombes RC, Ellison ML, Easty GC, et al., 1976, The ectopic secretion of calcitonin by lung and breast carcinomas., Clin Endocrinol (Oxf), Vol: 5 Suppl, Pages: 387S-396S, ISSN: 0300-0664
Many patients with advanced non-thyroid malignancies have elevated plasma immunoreactive calcitonin concentrations. Breast and bronchial carcinomas contain immunoreactive calcitonin and an epidermoid bronchial carcinoma has been shown to produce immunoreactive calcitonin in vitro. We have established monolayer cultures of breast carcinomas and eight out of fifteen consecutive carcinomas released immunoreactive calcitonin; some released HCG (human chorionic gonadotrophin) or CEA (carcinoembryonic antigen). In addition, a primary human breast carcinoma has been shown to release and contain calcitonin after being passaged in 'nude' mice over 1 year. Chromatography of extracts and culture media of a bronchical carcinoma demonstrated that, in contrast with the other tumours, it secreted a form or forms of calcitonin having size, charge and immunological differences when compared to calcitonin M. Preliminary evaluation of plasma immunoreactive calcitonin estimations in patients with breast carcinoma showed that twenty-three out of twenty-eight patients with metastatic disease had elevated plasma calcitonin concentrations, whereas only one out of thirteen with localized disease had high levels.
HILLYARD CJ, COOMBES RC, GREENBERG PB, et al., 1976, IMMUNOREACTIVE CALCITONIN IN NON-THYROID TUMORS, CALCIFIED TISSUE RESEARCH, Vol: 21, Pages: 304-309
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- Citations: 1
ELLISON ML, HILLYARD CJ, BLOOMFIELD GA, et al., 1976, ECTOPIC HORMONE PRODUCTION BY BRONCHIAL CARCINOMAS IN CULTURE, CLINICAL ENDOCRINOLOGY, Vol: 5, Pages: S397-S406, ISSN: 0300-0664
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- Citations: 26
Hillyard CJ, Coombes RC, Greenberg PB, et al., 1975, Proceedings: Immunoreactive calcitonin in patients with carcinomata., J Endocrinol, Vol: 66, Pages: 2P-3P, ISSN: 0022-0795
COOMBES RC, EASTY GC, DETRE SI, et al., 1975, SECRETION OF IMMUNOREACTIVE CALCITONIN BY HUMAN BREAST CARCINOMAS, BMJ-BRITISH MEDICAL JOURNAL, Vol: 4, Pages: 197-199, ISSN: 1756-1833
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- Citations: 63
ELLISON M, WOODHOUSE D, HILLYARD C, et al., 1975, IMMUNOREACTIVE CALCITONIN PRODUCTION BY HUMAN LUNG CARCINOMA CELLS IN CULTURE, BRITISH JOURNAL OF CANCER, Vol: 32, Pages: 373-379, ISSN: 0007-0920
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- Citations: 95
HILLYARD CJ, COOMBES RC, GREENBERG PB, et al., 1975, IMMUNOREACTIVE CALCITONIN IN PATIENTS WITH CARCINOMATA, JOURNAL OF ENDOCRINOLOGY, Vol: 66, Pages: P2-P3, ISSN: 0022-0795
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- Citations: 2
GREENFIELD B, 1974, PLASMA-CALCITONIN AND NON-THYROID TUMORS, LANCET, Vol: 2, Pages: 164-164, ISSN: 0140-6736
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- Citations: 2
COOMBES RC, HILLYARD C, GREENBER PB, et al., 1974, PLASMA-CALCITONIN AND NON-THYROID TUMORS - REPLY, LANCET, Vol: 2, Pages: 164-164, ISSN: 0140-6736
COOMBES RC, HILLYARD C, GREENBERG PB, et al., 1974, PLASMA-IMMUNOREACTIVE-CALCITONIN IN PATIENTS WITH NON-THYROID TUMORS, LANCET, Vol: 1, Pages: 1080-1083, ISSN: 0140-6736
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- Citations: 205
COOMBES RC, FOWLES TJ, DOWSETT M, et al., CLINICAL-STUDIES WITH 4-HYDROXYANDROSTENEDIONE IN BREAST-CANCER PATIENTS, ANTICANCER RESEARCH, Vol: 6, Pages: 876-876, ISSN: 0250-7005
MANSI JL, COOMBES RC, TREATMENT OF METASTATIC DISEASE, DIAGNOSTIC ONCOLOGY, Vol: 1, Pages: 161-167, ISSN: 1013-8129
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- Citations: 1
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