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@article{Schilling:2021:mtomcs/mfab020,
author = {Schilling, K and Moore, RET and Sullivan, KV and Capper, M and Rehkamper, M and Goddard, K and Ion, C and Coombes, RC and Vesty-Edwards, L and Lamb, AD and Halliday, AN and Larner, F},
doi = {mtomcs/mfab020},
journal = {Metallomics: integrated biometal science},
pages = {1--10},
title = {Zinc stable isotopes in urine as diagnostic for cancer of secretory organs},
url = {http://dx.doi.org/10.1093/mtomcs/mfab020},
volume = {13},
year = {2021}
}

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TY  - JOUR
AB  - Breast, prostate, and pancreatic cancers alter the zinc (Zn) metabolism. Combined analyses of urinary Zn concentrations [Zn] and Zn stable isotope compositions (δ66Zn) may provide a non-invasive approach for tracing malignancy-induced Zn dyshomeostasis. In this study, we measured [Zn] and δ66Zn in urine from prostate (n = 22), breast (n = 16), and from women with benign breast disease (n = 14) and compared those with age-matched healthy controls (22–49 years or 50+ years) and published data for pancreatic cancer (n = 17). Our results show that cancer-induced changes are reflected in higher urinary [Zn] and lower urinary δ66Zn for pancreatic and prostate cancer and benign breast disease when compared with healthy controls. For prostate cancer, the progression of low [Zn] and high δ66Zn for patients of low-risk disease toward high [Zn] and low δ66Zn for the higher risk patients demonstrates that [Zn] and δ66Zn in urine could serve as a reliable prognostic tool. Urinary excretion of isotopically light Zn by patients with prostatic and pancreatic cancer is probably the result of increased reactive oxygen species in cancerous cells, which limits the scavenging of hydroxyl radicals and thus facilitates the oxidation of metalloproteins with sulfur-rich ligands. Urine from breast cancer patients shows undistinguishable δ66Zn to healthy controls, implying that the expression of metalloproteins with sulfur-rich ligands is stronger in breast cancer tissues. In conclusion, urinary δ66Zn may provide a non-invasive diagnostic tool for pancreatic cancer and support disease prognosis for prostate cancer. These findings should translate to comprehensive transverse and longitudinal cohort studies in future.
AU  - Schilling,K
AU  - Moore,RET
AU  - Sullivan,KV
AU  - Capper,M
AU  - Rehkamper,M
AU  - Goddard,K
AU  - Ion,C
AU  - Coombes,RC
AU  - Vesty-Edwards,L
AU  - Lamb,AD
AU  - Halliday,AN
AU  - Larner,F
DO  - mtomcs/mfab020
EP  - 10
PY  - 2021///
SN  - 1756-5901
SP  - 1
TI  - Zinc stable isotopes in urine as diagnostic for cancer of secretory organs
T2  - Metallomics: integrated biometal science
UR  - http://dx.doi.org/10.1093/mtomcs/mfab020
UR  - http://hdl.handle.net/10044/1/89451
VL  - 13
ER  -

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