Imperial College London
Alternate

Emeritus ProfessorCharlesCoutelle

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor
 
 
 
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Contact

 

+44 (0)7906 614 491c.coutelle

 
 
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Location

 

Open SpaceSir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Coutelle:2012:10.1007/978-1-61779-873-3_17,
author = {Coutelle, C and Ashcroft, R},
doi = {10.1007/978-1-61779-873-3_17},
journal = {Methods Mol Biol},
pages = {371--387},
title = {Risks, benefits and ethical, legal, and societal considerations for translation of prenatal gene therapy to human application.},
url = {http://dx.doi.org/10.1007/978-1-61779-873-3_17},
volume = {891},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The still experimental nature of prenatal gene therapy carries a certain degree of risk, both for the pregnant mother as well as for the fetus. Some of the risks are procedural hazards already known from more conventional fetal medicine interventions. Others are more specific to gene therapy such as the potential for interference with normal fetal development, the possibility of inadvertent germ line gene transfer, and the danger of oncogenesis. This chapter reviews the potential risks in relation to the expected benefits of prenatal gene therapy. It discusses the scientific, ethical, legal, and social implications of this novel preventive approach to genetic disease and outlines preconditions to be met in preparation for a potential future clinical application.
AU  - Coutelle,C
AU  - Ashcroft,R
DO  - 10.1007/978-1-61779-873-3_17
EP  - 387
PY  - 2012///
SP  - 371
TI  - Risks, benefits and ethical, legal, and societal considerations for translation of prenatal gene therapy to human application.
T2  - Methods Mol Biol
UR  - http://dx.doi.org/10.1007/978-1-61779-873-3_17
UR  - https://www.ncbi.nlm.nih.gov/pubmed/22648781
VL  - 891
ER  -
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