Imperial College London
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Dr Charlotte Dean

Faculty of Medicine, National Heart & Lung Institute

Reader in Lung Development and Disease
 
 
 
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Contact

 

+44 (0)20 7594 3174c.dean

 
 
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Location

 

110Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dean:2018:10.1002/path.5158,
author = {Dean, C and Papakrivopoulou, E and Vasilopoulou, E and Lindenmeyer, M and Pacheco, S and Brzoska, H and Price, K and Kolatsi-Joannou, M and White, K and Henderson, D and Cohen, C and Salama, A and Woolf, A},
doi = {10.1002/path.5158},
journal = {Journal of Pathology},
pages = {485--496},
title = {Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury},
url = {http://dx.doi.org/10.1002/path.5158},
volume = {246},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Planar cell polarity (PCP) pathways control the orientation and alignment of epithelial cells within tissues. Van Goghlike 2 (Vangl2) is a key PCP protein that is required for normal differentiation of kidney glomeruli and tubules. Vangl2 has also been implicated in modifying the course of acquired glomerular disease and here we further explored how Vangl2 impacts on glomerular pathobiology in this context. Targeted genetic deletion of Vangl2 in mouse glomerular epithelial podocytes enhanced the severity of not only irreversible accelerated nephrotoxic nephritis but also lipopolysaccharideinduced reversible glomerular damage. In each proteinuric model, genetic deletion of Vangl2 in podocytes was associated with an increased ratio of activeMMP9 to inactive MMP9, an enzyme involved in tissue remodelling. Additionally, by interrogating microarray data from two cohorts of renal patients, we report increased VANGL2 transcript levels in glomeruli of individuals with focal segmental glomerulosclerosis, suggesting that the molecule may also be involved in certain human glomerular diseases. These observations support the conclusion that Vangl2 modulates glomerular injury, at least in part by acting as a brake on MMP9, a potentially harmful endogenous enzyme.
AU  - Dean,C
AU  - Papakrivopoulou,E
AU  - Vasilopoulou,E
AU  - Lindenmeyer,M
AU  - Pacheco,S
AU  - Brzoska,H
AU  - Price,K
AU  - Kolatsi-Joannou,M
AU  - White,K
AU  - Henderson,D
AU  - Cohen,C
AU  - Salama,A
AU  - Woolf,A
DO  - 10.1002/path.5158
EP  - 496
PY  - 2018///
SN  - 0022-3417
SP  - 485
TI  - Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury
T2  - Journal of Pathology
UR  - http://dx.doi.org/10.1002/path.5158
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/path.5158
UR  - http://hdl.handle.net/10044/1/63434
VL  - 246
ER  -
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