Imperial College London
Professor Carlo Di Mario

ProfessorCarloDi Mario

Faculty of Medicine, National Heart & Lung Institute

Professor in Cardiology
 
 
 
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Contact

 

+44 (0)20 7351 8615c.dimario

 
 
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Location

 

Sydney StreetRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Taggart:2015:10.1016/j.athoracsur.2015.01.060,
author = {Taggart, DP and Ben, Gal Y and Lees, B and Patel, N and Webb, C and Rehman, SM and Desouza, A and Yadav, R and De, Robertis F and Dalby, M and Banning, A and Channon, KM and Di, Mario C and Orion, E},
doi = {10.1016/j.athoracsur.2015.01.060},
journal = {Annals of Thoracic Surgery},
pages = {2039--2045},
title = {A randomized trial of external stenting for saphenous vein grafts in coronary artery bypass grafting},
url = {http://dx.doi.org/10.1016/j.athoracsur.2015.01.060},
volume = {99},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundExternal stents inhibit saphenous vein graft (SVG) intimal hyperplasia in animal studies. We investigated whether external stenting inhibits SVG diffuse intimal hyperplasia 1 year after coronary artery bypass graft surgery.MethodsThirty patients with multivessel disease undergoing coronary artery bypass graft surgery were enrolled. In addition to an internal mammary artery graft, each patient received one external stent to a single SVG randomly allocated to either the right or left coronary territories; and one or more nonstented SVG served as the control. Graft patency was confirmed at the end of surgery in all patients. The primary endpoint was SVG intimal hyperplasia (mean area) assessed by intravascular ultrasonography at 1 year. Secondary endpoints were SVG failure, ectasia (>50% initial diameter), and overall uniformity as judged by Fitzgibbon classification.ResultsOne-year follow-up angiography was completed in 29 patients (96.6%). All internal mammary artery grafts were patent. Overall SVG failure rates did not differ significantly between the two groups (30% stented versus 28.2% nonstented SVG, p = 0.55). The SVG mean intimal hyperplasia area, assessed in 43 SVGs, was significantly reduced in the stented group (4.37 ± 1.40 mm2) versus nonstented group (5.12 ± 1.35 mm2, p = 0.04). In addition, stented SVGs demonstrated marginally significant improvement in lumen uniformity (p = 0.08) and less ectasia (6.7% versus 28.2%, p = 0.05). There was some evidence that ligation of side branches with metallic clips increased SVG failure in the stented group.ConclusionsExternal stenting has the potential to improve SVG lumen uniformity and reduce diffuse intimal hyperplasia 1 year after coronary artery bypass graft surgery.
AU  - Taggart,DP
AU  - Ben,Gal Y
AU  - Lees,B
AU  - Patel,N
AU  - Webb,C
AU  - Rehman,SM
AU  - Desouza,A
AU  - Yadav,R
AU  - De,Robertis F
AU  - Dalby,M
AU  - Banning,A
AU  - Channon,KM
AU  - Di,Mario C
AU  - Orion,E
DO  - 10.1016/j.athoracsur.2015.01.060
EP  - 2045
PY  - 2015///
SN  - 0003-4975
SP  - 2039
TI  - A randomized trial of external stenting for saphenous vein grafts in coronary artery bypass grafting
T2  - Annals of Thoracic Surgery
UR  - http://dx.doi.org/10.1016/j.athoracsur.2015.01.060
UR  - http://hdl.handle.net/10044/1/53822
VL  - 99
ER  -
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