Imperial College London

DrCorneliusDonat

Faculty of MedicineDepartment of Brain Sciences

Research Associate
 
 
 
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Contact

 

c.donat

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Summary

I am a biologist working with Prof David J. Sharp and Dr Magdalena Sastre at the Department of Medicine, Imperial College.

My main research interests are disorders of the brain, primarily Traumatic Brain Injury (TBI), the connection with dementia and the underlying molecular processes. I have a particular interest in nicotinic acetylcholine receptors and how they are involved in cognitive dysfunction and inflammatory processes during TBI and neurodegenerative diseases. I have worked on the visualisation of these receptors with radioactive imaging techniques and will evaluate receptor-specific therapies in TBI and neurodegenerative diseases.

One of my research aims is to increase the understanding of the pathophysiological processes following TBI and how neuro- and molecular imaging can be used to identify major disease processes in order to support the development of new treatment strategies. For that purpose, I am employing models of TBI that reduce the complexity of the injury and allow the selective pharmacological manipulation.

Apart from neuroscience, I am also interested in the structure of totalitarian states, the organizational and linguistic strategies they employ and the dynamic interplay between groups, individuals and society.

Publications

Journals

Nutma E, Stephenson JA, Gorter RP, et al., 2019, A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis, Brain, Vol:142, ISSN:1460-2156, Pages:3440-3455

Sastre M, Edison P, Donat C, 2018, In vivo imaging of Glial activation in Alzheimer's disease, Frontiers in Neurology, Vol:9, ISSN:1664-2295

Donat CK, Scott G, Gentleman S, et al., 2017, Microglial activation in traumatic brain injury, Frontiers in Aging Neuroscience, Vol:9, ISSN:1663-4365

Kranz M, Sattler B, Tiepolt S, et al., 2016, Radiation dosimetry of the alpha(4)beta(2) nicotinic receptor ligand (+)-[F-18]flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results, Ejnmmi Physics, Vol:3, ISSN:2197-7364

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