My main research interests are disorders of the brain, primarily Traumatic Brain Injury (TBI), the connection with dementia and the underlying molecular processes. I have a particular interest in nicotinic acetylcholine receptors and how they are involved in cognitive dysfunction and inflammatory processes during TBI and neurodegenerative diseases. I have worked on the visualisation of these receptors with radioactive imaging techniques and will evaluate receptor-specific therapies in TBI and neurodegenerative diseases.
One of my research aims is to increase the understanding of the pathophysiological processes following TBI and how neuro- and molecular imaging can be used to identify major disease processes in order to support the development of new treatment strategies. For that purpose, I am employing models of TBI that reduce the complexity of the injury and allow the selective pharmacological manipulation.
Apart from neuroscience, I am also interested in the structure of totalitarian states, the organizational and linguistic strategies they employ and the dynamic interplay between groups, individuals and society.
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Sastre M, Edison P, Donat C, 2018, In vivo imaging of Glial activation in Alzheimer's disease, Frontiers in Neurology, Vol:9, ISSN:1664-2295
et al., 2017, Microglial activation in traumatic brain injury, Frontiers in Aging Neuroscience, Vol:9, ISSN:1663-4365
et al., 2016, Radiation dosimetry of the alpha(4)beta(2) nicotinic receptor ligand (+)-[F-18]flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results, Ejnmmi Physics, Vol:3, ISSN:2197-7364