Imperial College London
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Professor Christl Donnelly CBE FMedSci FRS

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.donnelly Website

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dorigatti:2021:10.1038/s41467-021-24622-7,
author = {Dorigatti, I and Lavezzo, E and Manuto, L and Ciavarella, C and Pacenti, M and Boldrin, C and Cattai, M and Saluzzo, F and Franchin, E and Del, Vecchio C and Caldart, F and Castelli, G and Nicoletti, M and Nieddu, E and Salvadoretti, E and Labella, B and Fava, L and Guglielmo, S and Gascina, M and Grazioli, M and Alvisi, G and Vanuzzo, MC and Zupo, T and Calandrin, R and Lisi, V and Rossi, L and Castagliuolo, I and Merigliano, S and Unwin, J and Plebani, M and Padoan, A and Brazzale, AR and Toppo, S and Ferguson, N and Donnelly, C and Crisanti, A},
doi = {10.1038/s41467-021-24622-7},
journal = {Nature Communications},
pages = {1--11},
title = {SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’},
url = {http://dx.doi.org/10.1038/s41467-021-24622-7},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In February and March 2020, two mass swab testing campaigns were conducted in Vo’, Italy. In May 2020, we tested 86% of the Vo’ population with three immuno-assays detecting antibodies against the spike and nucleocapsid antigens, a neutralisation assay and Polymerase Chain Reaction (PCR). Subjects testing positive to PCR in February/March or a serological assay in May were tested again in November. Here we report on the results of the analysis of the May and November surveys. We estimate a seroprevalence of 3.5% (95% Credible Interval (CrI): 2.8%-4.3%) in May. In November, 98.8% (95% Confidence Interval (CI): 93.7%-100.0%) of sera which tested positive in May still reacted against at least one antigen; 18.6% (95%CI:11.0%-28.5%) showed an increase of antibody or neutralisation reactivity from May. Analysis of the serostatus of the members of 1,118 households indicates a 26.0% (95%CrI:17.2%-36.9%) Susceptible-Infectious Transmission Probability. Contact tracing had limited impact on epidemic suppression.
AU  - Dorigatti,I
AU  - Lavezzo,E
AU  - Manuto,L
AU  - Ciavarella,C
AU  - Pacenti,M
AU  - Boldrin,C
AU  - Cattai,M
AU  - Saluzzo,F
AU  - Franchin,E
AU  - Del,Vecchio C
AU  - Caldart,F
AU  - Castelli,G
AU  - Nicoletti,M
AU  - Nieddu,E
AU  - Salvadoretti,E
AU  - Labella,B
AU  - Fava,L
AU  - Guglielmo,S
AU  - Gascina,M
AU  - Grazioli,M
AU  - Alvisi,G
AU  - Vanuzzo,MC
AU  - Zupo,T
AU  - Calandrin,R
AU  - Lisi,V
AU  - Rossi,L
AU  - Castagliuolo,I
AU  - Merigliano,S
AU  - Unwin,J
AU  - Plebani,M
AU  - Padoan,A
AU  - Brazzale,AR
AU  - Toppo,S
AU  - Ferguson,N
AU  - Donnelly,C
AU  - Crisanti,A
DO  - 10.1038/s41467-021-24622-7
EP  - 11
PY  - 2021///
SN  - 2041-1723
SP  - 1
TI  - SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-24622-7
UR  - https://www.nature.com/articles/s41467-021-24622-7
UR  - http://hdl.handle.net/10044/1/89915
VL  - 12
ER  -
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