Imperial College London
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Professor Christl Donnelly CBE FMedSci FRS

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.donnelly Website

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Chadeau-Hyam:2021,
author = {Chadeau-Hyam, M and Wang, H and Eales, O and Haw, D and Bodinier, B and Whitaker, M and Walters, C and Ainslie, K and Atchison, C and Fronterre, C and Diggle, P and Page, A and Trotter, A and COG-UK, TCGUKC and Ashby, D and Barclay, W and Taylor, G and Cooke, G and Ward, H and Darzi, A and Riley, S and Donnelly, C and Elliott, P},
title = {REACT-1 study round 14: High and increasing prevalence of SARS-CoV-2 infection among school-aged children during September 2021 and vaccine effectiveness against infection in England},
url = {http://hdl.handle.net/10044/1/91999},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Background: England experienced a third wave of the COVID-19 epidemic from end May2021 coinciding with the rapid spread of Delta variant. Since then, the population eligible forvaccination against COVID-19 has been extended to include all 12-15-year-olds, and abooster programme has been initiated among adults aged 50 years and over, health careand care home workers, and immunocompromised people. Meanwhile, schoolchildren havereturned to school often with few COVID-19-related precautions in place.Methods: In the REal-time Assessment of Community Transmission-1 (REACT-1) study,throat and nose swabs were sent to non-overlapping random samples of the populationaged 5 years and over in England. We analysed prevalence of SARS-CoV-2 using reversetranscription-polymerase chain reaction (RT-PCR) swab-positivity data from REACT-1 round14 (between 9 and 27 September 2021). We combined results for round 14 with round 13(between 24 June and 12 July 2021) and estimated vaccine effectiveness and prevalence ofswab-positivity among double-vaccinated individuals. Unlike all previous rounds, in round 14,we switched from dry swabs transported by courier on a cold chain to wet swabs usingsaline. Also, at random, 50% of swabs (not chilled until they reached the depot) weretransported by courier and 50% were sent through the priority COVID-19 postal service.Results: We observed stable or rising prevalence (with an R of 1.03 (0.94, 1.14) overall)during round 14 with a weighted prevalence of 0.83% (0.76%, 0.89%). The highest weightedprevalence was found in children aged 5 to 12 years at 2.32% (1.96%, 2.73%) and 13 to 17years at 2.55% (2.11%, 3.08%). All positive virus samples analysed correspond to the Deltavariant or sub-lineages of Delta with one instance of the E484K escape mutation detected.The epidemic was growing in those aged 17 years and under with an R of 1.18 (1.03, 1.34),but decreasing in those aged 18 to 54 years with an R of 0.81 (0.68, 0.97). For allparticipants and all vaccin
AU  - Chadeau-Hyam,M
AU  - Wang,H
AU  - Eales,O
AU  - Haw,D
AU  - Bodinier,B
AU  - Whitaker,M
AU  - Walters,C
AU  - Ainslie,K
AU  - Atchison,C
AU  - Fronterre,C
AU  - Diggle,P
AU  - Page,A
AU  - Trotter,A
AU  - COG-UK,TCGUKC
AU  - Ashby,D
AU  - Barclay,W
AU  - Taylor,G
AU  - Cooke,G
AU  - Ward,H
AU  - Darzi,A
AU  - Riley,S
AU  - Donnelly,C
AU  - Elliott,P
PY  - 2021///
TI  - REACT-1 study round 14: High and increasing prevalence of SARS-CoV-2 infection among school-aged children during September 2021 and vaccine effectiveness against infection in England
UR  - http://hdl.handle.net/10044/1/91999
ER  -
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