Imperial College London
Dr Claire Durant

DrClaireDurant

Faculty of Medicine, Department of Brain Sciences

Research Associate
 
 
 
//

Contact

 

c.durant

 
 
//

Location

 

Burlington DanesHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Hellmich:2015:10.1186/s12881-015-0244-4,
author = {Hellmich, C and Durant, C and Jones, MW and Timpson, NJ and Bartsch, U and Corbin, LJ},
doi = {10.1186/s12881-015-0244-4},
journal = {BMC Medical Genetics},
title = {Genetics, sleep and memory: a recall-by-genotype study of ZNF804A variants and sleep neurophysiology},
url = {http://dx.doi.org/10.1186/s12881-015-0244-4},
volume = {16},
year = {2015}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Schizophrenia is a complex, polygenic disorder for which over 100 genetic variants have been identified that correlate with diagnosis. However, the biological mechanisms underpinning the different symptom clusters remain undefined. The rs1344706 single nucleotide polymorphism within ZNF804A was among the first genetic variants found to be associated with schizophrenia. Previously, neuroimaging and cognitive studies have revealed several associations between rs1344706 and brain structure and function. The aim of this study is to use a recall-by-genotype (RBG) design to investigate the biological basis for the association of ZNF804A variants with schizophrenia. A RBG study, implemented in a population cohort, will be used to evaluate the impact of genetic variation at rs1344706 on sleep neurophysiology and procedural memory consolidation in healthy participants. METHODS/DESIGN: Participants will be recruited from the Avon Longitudinal Study of Parents and Children (ALSPAC) on the basis of genotype at rs1344706 (n = 24). Each participant will be asked to take part in two nights of in-depth sleep monitoring (polysomnography) allowing collection of neurophysiological sleep data in a manner not amenable to large-scale study. Sleep questionnaires will be used to assess general sleep quality and subjective sleep experience after each in-house recording. A motor sequencing task (MST) will be performed before and after the second night of polysomnography. In order to gather additional data about habitual sleep behaviour participants will be asked to wear a wrist worn activity monitor (actiwatch) and complete a sleep diary for two weeks. DISCUSSION: This study will explore the biological function of ZNF804A genotype (rs1344706) in healthy volunteers by examining detailed features of sleep architecture and physiology in relation to motor learning. Using a RBG approach will enable us to collect precise and detailed phenotypic data whilst achieving an informative biol
AU  - Hellmich,C
AU  - Durant,C
AU  - Jones,MW
AU  - Timpson,NJ
AU  - Bartsch,U
AU  - Corbin,LJ
DO  - 10.1186/s12881-015-0244-4
PY  - 2015///
SN  - 1471-2350
TI  - Genetics, sleep and memory: a recall-by-genotype study of ZNF804A variants and sleep neurophysiology
T2  - BMC Medical Genetics
UR  - http://dx.doi.org/10.1186/s12881-015-0244-4
UR  - http://hdl.handle.net/10044/1/38473
VL  - 16
ER  -
Download