Imperial College London

ProfessorCostanzaEmanueli

Faculty of MedicineNational Heart & Lung Institute

Chair in Cardiovascular Science
 
 
 
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Contact

 

c.emanueli Website

 
 
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Location

 

434ICTEM buildingHammersmith Campus

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Summary

 

Summary

Our team develops fundamental and translational research focussing on ischaemic disease, diabetes cardiovascular complications, cardiac surgery and cardio-oncology. We aim to decipher the molecular causes of cardiovascular pathologies and to develop novel approaches of cardiovascular protection and repair.  Moreover, we investigate new biomarkers to support the development of clinical studies and improve clinical practice.

We are part of local, national and international research networks, including a Leducq Transatlantic Network of Excellence in Vascular miRNAs (MIRVAD https://www.fondationleducq.org/network/microrna-based-therapeutic-strategies-in-vascular-disease-mirvad/ ), the BHF Centre of Regenerative Medicine https://www.cvs.ed.ac.uk/node/1077  an EEU COST action on Cardio RNAs http://www.cost.eu/COST_Actions/ca/CA17129 and a large EEU grant MEDIRAD http://www.medirad-project.eu/ assessing the collateral damage of the impact of low dose radiotherapy.

I have recently transferred my group to Imperial College London from the University of Bristol, where I have maintained open collaborations.

Areas of particular expertise and interests are the following:

  • Regulatory RNAs
  • Extracellular vesicles
  • Therapeutic angiogenesis
  • Diabetes and Ischaemic disease

 HONOURS AND MEMBERSHIPS

Prize and Honours

2001                          Italian Society of Cardiology International Fellowship 

2001                          American Heart Association New European Investigator     Travel Award 

2003                          Member European Vascular Genomics Network of Excellence (EVGN)

2007                          Fellow American Heart Association (FAHA)

2008                          Elected member Bristol Heart Institute steering committee

2009                          Michael Davis Early-Career prize

2009-13                     Circulation Research Top Review Award


ADVISORY BOARDS 


American Society of Gene & Cell Therapy board membership

Diabetes UK Science & Research Advisory Group (SRAG) membership


Editorial Boards

Circulation Research (since 2007)

Arteriosclerosis Thrombosis Vascular Biology (since 2009)

Molecular Therapy (since April 2014)

PLOS One (since 2010),

Vascular Pharmacology (since 2008)

Frontiers in Surgery (specialty section Heart Surgery) (since April 2014)

Journal of Heart Surgery and Treatment (since 2014)

British Journal of Pharmacology (2006-2010)

 

RESEARCH

Research keywords

  • Regulatory RNAs
  • Extracellular vesicles
  • Therapeutic angiogenesis
  • Diabetes
  • Ischaemic disease

PUBLICATIONS

PEER-REVIEWED RESEARCH ARTICLES

SELECTED PEER-REVIEWED REVIEW ARTICLES

 

 

SELECTED INVITED COMMENTARIES

 

     

     

      Selected Publications

      Journal Articles

      Aday S, Zoldan J, Besnier M, et al., 2017, Synthetic microparticles conjugated with VEGF(165) improve the survival of endothelial progenitor cells via microRNA-17 inhibition, Nature Communications, Vol:8, ISSN:2041-1723

      Coumans FAW, Brisson AR, Buzas EI, et al., 2017, Methodological Guidelines to Study Extracellular Vesicles, Circulation Research, Vol:120, ISSN:0009-7330, Pages:1632-1648

      Beltrami C, Besnier M, Shantikumar S, et al., 2017, Human pericardial fluid contains exosomes enriched with cardiovascular-expressed microRNAs and promotes therapeutic angiogenesis, Molecular Therapy, Vol:25, ISSN:1525-0016, Pages:679-693

      Emanueli C, Shearn AIU, Laftah A, et al., 2016, Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery, PLOS One, Vol:11, ISSN:1932-6203

      Caporali A, Meloni M, Nailor A, et al., 2015, p75(NTR)-dependent activation of NF-kappa B regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia, Nature Communications, Vol:6, ISSN:2041-1723

      Floris I, Descamps B, Vardeu A, et al., 2015, Gestational Diabetes Mellitus Impairs Fetal Endothelial Cell Functions Through a Mechanism Involving MicroRNA-101 and Histone Methyltransferase Enhancer of Zester Homolog-2, Arteriosclerosis Thrombosis and Vascular Biology, Vol:35, ISSN:1079-5642, Pages:664-674

      Mitic T, Caporali A, Floris I, et al., 2015, EZH2 Modulates Angiogenesis In Vitro and in a Mouse Model of Limb Ischemia, Molecular Therapy, Vol:23, ISSN:1525-0016, Pages:32-42

      Spinetti G, Fortunato O, Caporali A, et al., 2013, MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia., Circ Res, Vol:112, Pages:335-346

      Caporali A, Meloni M, Miller AM, et al., 2012, Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia., Arterioscler Thromb Vasc Biol, Vol:32, Pages:e149-e160

      Meloni M, Descamps B, Caporali A, et al., 2012, Nerve growth factor gene therapy using adeno-associated viral vectors prevents cardiomyopathy in type 1 diabetic mice., Diabetes, Vol:61, Pages:229-240

      Caporali A, Meloni M, Völlenkle C, et al., 2011, Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia., Circulation, Vol:123, Pages:282-291

      Meloni M, Caporali A, Graiani G, et al., 2010, Nerve Growth Factor Promotes Cardiac Repair following Myocardial Infarction, Circulation Research, Vol:106, ISSN:0009-7330, Pages:1275-U230

      Caporali A, Emanueli C, 2009, Cardiovascular actions of neurotrophins., Physiological Reviews, Vol:89, ISSN:0031-9333, Pages:279-308

      More Publications