Summary
I am currently the British Heart Foundation Chair in Cardiovascular Science at the Imperial College.
Our team develops fundamental and transnational research focusing on ischaemic disease, cardiac remodeling and diabetes cardiovascular complications. We investigate the molecular causes underpinning cardiovascular disease with the aim to develop novel approaches of protection and repair.
We are part of local, national and international research initiatives and happy to discuss new collaborations. We are also involved in teaching and supervision of master and PhD students.
Our team embraces the EDI principles and is invested in supporting early career scientists as well as the wider scientific community and society via targeted dissemination activities
Research keywords
- Ischaemic disease
- Diabetes complications
- Cardiac remodelling
- Therapeutic angiogenesis
- Regulatory RNAs
- RNA modifications
- Extracellular vesicles and other nanoparticles
- Nanomedicine
- Bioengineering
- Bioinformatics
Selected Publications
Journal Articles
Aday S, Zoldan J, Besnier M, et al., 2017, Synthetic microparticles conjugated with VEGF(165) improve the survival of endothelial progenitor cells via microRNA-17 inhibition, Nature Communications, Vol:8, ISSN:2041-1723, Pages:1-14
Coumans FAW, Brisson AR, Buzas EI, et al., 2017, Methodological Guidelines to Study Extracellular Vesicles, Circulation Research, Vol:120, ISSN:0009-7330, Pages:1632-1648
Beltrami C, Besnier M, Shantikumar S, et al., 2017, Human pericardial fluid contains exosomes enriched with cardiovascular-expressed microRNAs and promotes therapeutic angiogenesis, Molecular Therapy, Vol:25, ISSN:1525-0016, Pages:679-693
Emanueli C, Shearn AIU, Laftah A, et al., 2016, Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery, PLOS One, Vol:11, ISSN:1932-6203
Caporali A, Meloni M, Nailor A, et al., 2015, p75(NTR)-dependent activation of NF-kappa B regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia, Nature Communications, Vol:6, ISSN:2041-1723, Pages:1-13
Floris I, Descamps B, Vardeu A, et al., 2015, Gestational Diabetes Mellitus Impairs Fetal Endothelial Cell Functions Through a Mechanism Involving MicroRNA-101 and Histone Methyltransferase Enhancer of Zester Homolog-2, Arteriosclerosis Thrombosis and Vascular Biology, Vol:35, ISSN:1079-5642, Pages:664-674
Mitic T, Caporali A, Floris I, et al., 2015, EZH2 Modulates Angiogenesis <i>In Vitro</i> and in a Mouse Model of Limb Ischemia, Molecular Therapy, Vol:23, ISSN:1525-0016, Pages:32-42
Spinetti G, Fortunato O, Caporali A, et al., 2013, MicroRNA-15a and MicroRNA-16 Impair Human Circulating Proangiogenic Cell Functions and Are Increased in the Proangiogenic Cells and Serum of Patients With Critical Limb Ischemia, Circulation Research, Vol:112, ISSN:0009-7330
Caporali A, Meloni M, Miller AM, et al., 2012, Soluble ST2 Is Regulated by p75 Neurotrophin Receptor and Predicts Mortality in Diabetic Patients With Critical Limb Ischemia, Arteriosclerosis Thrombosis and Vascular Biology, Vol:32, ISSN:1079-5642, Pages:E149-+
Meloni M, Descamps B, Caporali A, et al., 2012, Nerve Growth Factor Gene Therapy Using Adeno-Associated Viral Vectors Prevents Cardiomyopathy in Type 1 Diabetic Mice, Diabetes, Vol:61, ISSN:0012-1797, Pages:229-240
Caporali A, Meloni M, Voellenkle C, et al., 2011, Deregulation of microRNA-503 Contributes to Diabetes Mellitus-Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia, Circulation, Vol:123, ISSN:0009-7322, Pages:282-U117
Meloni M, Caporali A, Graiani G, et al., 2010, Nerve Growth Factor Promotes Cardiac Repair following Myocardial Infarction, Circulation Research, Vol:106, ISSN:0009-7330, Pages:1275-U230
Caporali A, Emanueli C, 2009, Cardiovascular Actions of Neurotrophins, Physiological Reviews, Vol:89, ISSN:0031-9333, Pages:279-308