ProfessorCostanzaEmanueli

Summary

Our team develops fundamental and translational research focussing on ischaemic disease, diabetes cardiovascular complications, cardiac surgery and cardio-oncology. We aim to decipher the molecular causes of cardiovascular pathologies and to develop novel approaches of cardiovascular protection and repair.  Moreover, we investigate new biomarkers to support the development of clinical studies and improve clinical practice.

We are part of local, national and international research networks, including a Leducq Transatlantic Network of Excellence in Vascular miRNAs (MIRVAD https://www.fondationleducq.org/network/microrna-based-therapeutic-strategies-in-vascular-disease-mirvad/ ), the BHF Centre of Regenerative Medicine https://www.cvs.ed.ac.uk/node/1077  an EEU COST action on Cardio RNAs http://www.cost.eu/COST_Actions/ca/CA17129 and a large EEU grant MEDIRAD http://www.medirad-project.eu/ assessing the collateral damage of the impact of low dose radiotherapy.

I have recently transferred my group to Imperial College London from the University of Bristol, where I have maintained open collaborations.

Areas of particular expertise and interests are the following:

• Regulatory RNAs
• Extracellular vesicles
• Therapeutic angiogenesis
• Diabetes and Ischaemic disease

 HONOURS AND MEMBERSHIPS

Prize and Honours

2001                          Italian Society of Cardiology International Fellowship 

2001                          American Heart Association New European Investigator     Travel Award 

2003                          Member European Vascular Genomics Network of Excellence (EVGN)

2007                          Fellow American Heart Association (FAHA)

2008                          Elected member Bristol Heart Institute steering committee

2009                          Michael Davis Early-Career prize

2009-13                     Circulation Research Top Review Award

ADVISORY BOARDS 

American Society of Gene & Cell Therapy board membership

Diabetes UK Science & Research Advisory Group (SRAG) membership

Editorial Boards

Circulation Research (since 2007)

Arteriosclerosis Thrombosis Vascular Biology (since 2009)

Molecular Therapy (since April 2014)

PLOS One (since 2010),

Vascular Pharmacology (since 2008)

Frontiers in Surgery (specialty section Heart Surgery) (since April 2014)

Journal of Heart Surgery and Treatment (since 2014)

British Journal of Pharmacology (2006-2010)

 

RESEARCH

Research keywords

• Regulatory RNAs
• Extracellular vesicles
• Therapeutic angiogenesis
• Diabetes
• Ischaemic disease

PUBLICATIONS

PEER-REVIEWED RESEARCH ARTICLES

• Boin F, Erre GL, Posadino AM, Cossu A, Giordo R, Spinetti G, Passiu G, Emanueli C, Pintus G. Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension. Orphanet J Rare Dis. 2014 Aug 1;9:123.
•  Avolio E, Gianfranceschi G, Cesselli D, Caragnano A, Athanasakis E, Katare R, Meloni M, Palma A, Barchiesi A, Vascotto C, Toffoletto B, Mazzega E, Finato N, Aresu G, Livi U, Emanueli C, Scoles G, Beltrami CA, Madeddu P, Beltrami AP. Ex vivo molecular rejuvenation improves the therapeutic activity of senescent human cardiac stem cells in a mouse model of myocardial infarction. Stem Cells. 2014 Sep;32(9):2373-85.
• Moore A, Shindikar A, Fomison-Nurse I, Riu F, Munasinghe P, Parshu Ram T, Saxena P, Coffey S, Bunton RW, Galvin IF, Williams MJ, Emanueli C, Madeddu P, Katare R. Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1. Cardiovasc Diabetol. 2014 Apr 1;13(1):68. [Epub ahead of print]
• Spinetti G, Specchia C, Fortunato O, Sangalli E, Clerici G, Caminiti M, Airoldi F, Losa S, Emanueli C, Faglia E, Madeddu P.  Migratory Activity of Circulating Mononuclear Cells Is Associated With Cardiovascular Mortality in Type 2 Diabetic Patients With Critical Limb Ischemia. Diabetes Care. 2014 Feb 26. [Epub ahead of print]
• Meloni M, Marchetti M, Garner K, Littlejohns B, Sala-Newby G, Xenophontos N, Floris I, Suleiman MS, Madeddu P, Caporali A, Emanueli C. Local inhibition of microRNA-24 improves reparative angiogenesis and left ventricle remodeling and function in mice with myocardial infarction. Mol Ther. 2013 Jul;21(7):1390-402. .
• Jazwa A, Tomczyk M, Taha HM, Hytonen E, Stoszko M, Zentilin L, Giacca M, Yla-Herttuala S, Emanueli C, Jozkowicz A, Dulak J. Arteriogenic therapy based on simultaneous delivery of VEGF-A and FGF4 genes improves the recovery from acute limb ischemia. Vasc Cell. 2013 Jul 1;5(1):13.
• Katare R, Riu F, Rowlinson J, Lewis A, Holden R, Meloni M, Reni C, Wallrapp C, Emanueli C, Madeddu P. Perivascular delivery of encapsulated mesenchymal stem cells improves postischemic angiogenesis via paracrine activation of VEGF-A. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1872-80.
• Spinetti G, Cordella D, Fortunato O, Sangalli E, Losa S, Gotti A, Carnelli F, Rosa F, Riboldi S, Sessa F, Avolio E, Beltrami AP, Emanueli C, Madeddu P. Global remodeling of the vascular stem cell niche in bone marrow of diabetic patients: implication of the microRNA-155/FOXO3a signaling pathway. Circ Res. 2013 Feb 1;112(3):510-22.
• Spinetti G, Fortunato O, Caporali A, Shantikumar S, Marchetti M, Meloni M, Descamps B, Floris I, Sangalli E, Vono R, Faglia E, Specchia C, Pintus G, Madeddu P, Emanueli C. MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia. Circ Res. 2013 Jan 18;112(2):335-46.
• Cossu A, Posadino AM, Giordo R, Emanueli C, Sanguinetti AM, Piscopo A, Poiana M, Capobianco G, Piga A, Pintus G. Apricot melanoidins prevent oxidative endothelial cell death by counteracting mitochondrial oxidation and membrane depolarization. PLoSOne. 2012;7(11):e48817.
• Caporali A, Meloni M, Miller AM, Vierlinger K, Cardinali A, Spinetti G, Nailor A, Faglia E, Losa S, Gotti A, Fortunato O, Mitic T, Hofner M, Noehammer C, Madeddu P, Emanueli C. Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):e149-60.
• Jazwa A, Stepniewski J, Zamykal M, Jagodzinska J, Meloni M, Emanueli C, Jozkowicz A, Dulak J. Pre-emptive hypoxia-regulated HO-1 gene therapy improves post-ischaemic limb perfusion and tissue regeneration in mice. Cardiovasc Res. 2013 Jan 1;97(1):115-24.
• Katare R, Oikawa A, Cesselli D, Beltrami AP, Avolio E, Muthukrishnan D, Munasinghe PE, Angelini G, Emanueli C, Madeddu P. Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes. Cardiovasc Res. 2013 Jan 1;97(1):55-65.
• Amadesi S, Reni C, Katare R, Meloni M, Oikawa A, Beltrami AP, Avolio E, Cesselli D, Fortunato O, Spinetti G, Ascione R, Cangiano E, Valgimigli M, Hunt SP, Emanueli C, Madeddu P. Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects. Circulation. 2012 Apr 10;125(14):1774-86.
• Kane NM, Howard L, Descamps B, Meloni M, McClure J, Lu R, McCahill A, Breen C, Mackenzie RM, Delles C, Mountford JC, Milligan G, Emanueli C, Baker AH. Role of microRNAs 99b, 181a, and 181b in the differentiation of human embryonic stem cells to vascular endothelial cells. Stem Cells. 2012 Apr;30(4):643-54. doi: 10.1002/stem.1026.
• Meloni M, Descamps B, Caporali A, Zentilin L, Floris I, Giacca M, Emanueli C. Nerve growth factor gene therapy using adeno-associated viral vectors prevents cardiomyopathy in type 1 diabetic mice. Diabetes. 2012 Jan;61(1):229-40.
• Katare R, Riu F, Mitchell K, Gubernator M, Campagnolo P, Cui Y, Fortunato O, Avolio E, Cesselli D, Beltrami AP, Angelini G, Emanueli C, Madeddu P. Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circ Res. 2011 Sep 30;109(8):894-906.
• Katare R, Caporali A, Zentilin L, Avolio E, Sala-Newby G, Oikawa A, Cesselli D, Beltrami AP, Giacca M, Emanueli C, Madeddu P. Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circ Res. 2011 May 13;108(10):1238-51.
• Mangialardi G, Monopoli A, Ongini E, Spinetti G, Fortunato O, Emanueli C, Madeddu P. Nitric oxide-donating statin improves multiple functions of circulating angiogenic cells. Br J Pharmacol. 2011;164:570-83.
• Caporali A, Meloni M, Völlenkle C, Bonci D, Sala-Newby GB, Addis R, Spinetti G, Losa S, Masson R, Baker AH, Agami R, le Sage C, Condorelli G, Madeddu P, Martelli F, Emanueli C. Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation. 2011 Jan 25;123(3):282-91.
• Spinetti G, Fortunato O, Cordella D, Portararo P, Kränkel N, Katare R, Sala-Newby GB, Richer C, Vincent MP, Alhenc-Gelas F, Tonolo G, Cherchi S, Emanueli C, Madeddu P. Tissue kallikrein is essential for invasive capacity of circulating proangiogenic cells. Circ Res. 2011 Feb 4;108(3):284-93.
• Al Haj Zen A, Oikawa A, Bazan-Peregrino M, Meloni M, Emanueli C, Madeddu P. Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia. Circ Res. 2010 Jul 23;107(2):283-93.
• Dominek P, Campagnolo P, H-Zadeh M, Kränkel N, Chilosi M, Sharman JA, Caporali A, Mangialardi G, Spinetti G, Emanueli C, Pignatelli M, Madeddu P. Role of human tissue kallikrein in gastrointestinal stromal tumour invasion. Br J Cancer. 2010;103(9):1422-31.
• Katare R, Caporali A, Emanueli C, Madeddu P. Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response. J Mol Cell Cardiol. 2010;49:625-38.
• Kane NM, Meloni M, Spencer HL, Craig MA, Strehl R, Milligan G, Houslay MD, Mountford JC, Emanueli C, Baker AH. Derivation of endothelial cells from human embryonic stem cells by directed differentiation: analysis of microRNA and angiogenesis in vitro and in vivo. Arterioscler Thromb Vasc Biol. 2010 Jul;30(7):1389-97.
• Campagnolo P, Cesselli D, Al Haj Zen A, Beltrami AP, Kränkel N, Katare R, Angelini G, Emanueli C, Madeddu P. Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential. Circulation. 2010 Apr 20;121(15):1735-45.
• Cristofaro B, Stone OA, Caporali A, Dawbarn D, Ieronimakis N, Reyes M, Madeddu P, Bates DO, Emanueli C. Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1143-50.
• Meloni M, Caporali A, Graiani G, Lagrasta C, Katare R, Van Linthout S, Spillmann F, Campesi I, Madeddu P, Quaini F, Emanueli C.  Nerve growth factor promotes cardiac repair following myocardial infarction. Circ Res. 2010 Apr 16;106(7):1275-84.
• Katare RG, Caporali A, Oikawa A, Meloni M, Emanueli C, Madeddu P. Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway. Circ Heart Fail. 2010 Mar;3(2):294-305.
• Siragusa M, Katare R, Meloni M, Damilano F, Hirsch E, Emanueli C, Madeddu P. Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice. Circ Res. 2010 Mar 5;106(4):757-68.
• Oikawa A, Siragusa M, Quaini F, Mangialardi G, Katare RG, Caporali A, van Buul JD, van Alphen FP, Graiani G, Spinetti G, Kraenkel N, Prezioso L, Emanueli C, Madeddu P. Diabetes mellitus induces bone marrow microangiopathy. Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):498-508.
• Barcelos LS, Duplaa C, Kränkel N, Graiani G, Invernici G, Katare R, Siragusa M, Meloni M, Campesi I, Monica M, Simm A, Campagnolo P, Mangialardi G, Stevanato L, Alessandri G, Emanueli C, Madeddu P. Human CD133 progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling. Circ Res. 2009 May 8;104(9):1095-102.
• Stone OA, Richer C, Emanueli C, van Weel V, Quax PH, Katare R, Kraenkel N, Campagnolo P, Barcelos LS, Siragusa M, Sala-Newby GB, Baldessari D, Mione M, Vincent MP, Benest AV, Al Haj Zen A, Gonzalez J, Bates DO, Alhenc-Gelas F, Madeddu P. Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization. Arterioscler Thromb Vasc Biol. 2009;29:657-64.
• Azizi M, Emanueli C, Peyrard S, Maddedu P, Alhenc-Gelas F, Campbell DJ. Genetic and dietary control of plasma tissue kallikrein secretion and urinary kinins exretion in man. J Hypertens. 2008;26:714-20.
• Kränkel N, Katare RG, Siragusa M, Barcelos LS, Campagnolo P, Mangialardi G, Fortunato O, Spinetti G, Tran N, Zacharowski K, Wojakowski W, Mroz I, Herman A, Manning Fox JE, MacDonald PE, Schanstra JP, Bascands JL, Ascione R, Angelini G, Emanueli C, Madeddu P. Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential. Circ Res. 2008 Nov 21;103(11):1335-43.
• Caporali A, Pani E, Horrevoets AJ, Kraenkel N, Oikawa A, Sala-Newby GB, Meloni M, Cristofaro B, Graiani G, Leroyer AS, Boulanger CM, Spinetti G, Yoon SO, Madeddu P, Emanueli C. Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles. Circ Res. 2008 Jul 18;103(2):e15-26.
• Caporali A, Sala-Newby GB, Meloni M, Graiani G, Pani E, Cristofaro B, Newby AC, Madeddu P, Emanueli C. Identification of the prosurvival activity of nerve growth factor on cardiac myocytes. Cell Death Differ. 2008 Feb;15(2):299-311.
• Madeddu P, Kraenkel N, Barcelos LS, Siragusa M, Campagnolo P, Oikawa A, Caporali A, Herman A, Azzolino O, Barberis L, Perino A, Damilano F, Emanueli C, Hirsch E. Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions. Arterioscler Thromb Vasc Biol. 2008;28:68-76.
• Invernici G, Emanueli C, Madeddu P, Cristini S, Gadau S, Benetti A, Ciusani E, Stassi G, Siragusa M, Nicosia R, Peschle C, Fascio U, Colombo A, Rizzuti T, Parati E, Alessandri G. Human fetal aorta contains vascular progenitor cells capable of inducing vasculogenesis, angiogenesis, and myogenesis in vitro and in a murine model of peripheral ischemia. Am J Pathol. 2007;170:1879-92.
• Spillmann F, Graiani G, Van Linthout S, Meloni M, Campesi I, Lagrasta C, Westermann D, Tschöpe C, Quaini F, Emanueli C, Madeddu P. Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium. Regen Med. 2006;1:235-54.
• Emanueli C, Monopoli A, Kraenkel N, Meloni M, Gadau S, Campesi I, Ongini E, Madeddu P. Nitropravastatin stimulates reparative neovascularisation and improves recovery from limb Ischaemia in type-1 diabetic mice. Br J Pharmacol. 2007;150:873-82.
• Emanueli C, Caporali A, Krankel N, Cristofaro B, Van Linthout S, Madeddu P. Type-2 diabetic Lepr(db/db) mice show a defective microvascular phenotype under basal conditions and an impaired response to angiogenesis gene therapy in the setting of limb ischemia. Front Biosci. 2007;12:2003-12.
• Bianchi F, Rosi M, Vozzi G, Emanueli C, Madeddu P, Ahluwalia A. Microfabrication of fractal polymeric structures for capillary morphogenesis: applications in therapeutic angiogenesis and in the engineering of vascularized tissue. J Biomed Mater Res B Appl Biomater. 2007;81:462-8.
• Gadau S, Emanueli C, Van Linthout S, Graiani G, Todaro M, Meloni M, Campesi I, Invernici G, Spillmann F, Ward K, Madeddu P. Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis. Diabetologia. 2006;49:405-20.
• Graiani G, Lagrasta C, Migliaccio E, Spillmann F, Meloni M, Madeddu P, Quaini F, Padura IM, Lanfrancone L, Pelicci P, Emanueli C. Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage. Hypertension. 2005 Aug;46(2):433-40.
• Kirchmair R, Walter DH, Ii M, Rittig K, Tietz AB, Murayama T, Emanueli C, Silver M, Wecker A, Amant C, Schratzberger P, Yoon YS, Weber A, Panagiotou E, Rosen KM, Bahlmann FH, Adelman LS, Weinberg DH, Ropper AH, Isner JM, Losordo DW. Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth. Circulation. 2005 May 24;111(20):2662-70.
• Del Rosso A, Distler O, Milia AF, Emanueli C, Ibba-Manneschi L, Guiducci S, Conforti ML, Generini S, Pignone A, Gay S, Madeddu P, Matucci-Cerinic M. Increased circulating levels of tissue kallikrein in systemic sclerosis correlate with microvascular involvement. Ann Rheum Dis. 2005;64:382-7.
• Emanueli C, Salis MB, Van Linthout S, Meloni M, Desortes E, Silvestre JS, Clergue M, Figueroa CD, Gadau S, Condorelli G, Madeddu P. Akt/protein kinase B and endothelial nitric oxide synthase mediate muscular neovascularization induced by tissue kallikrein gene transfer. Circulation. 2004 Sep 21;110(12):1638-44.
• Madeddu P, Emanueli C, Pelosi E, Salis MB, Cerio AM, Bonanno G, Patti M, Stassi G, Condorelli G, Peschle C. Transplantation of low dose CD34 KDR cells promotes vascular and muscular regeneration in ischemic limbs. FASEB J. 2004 Nov;18(14):1737-9.
• Emanueli C, Van Linthout S, Salis MB, Monopoli A, Del Soldato P, Ongini E, Madeddu P. Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia. Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2082-7..
• Salis MB, Graiani G, Desortes E, Caldwell RB, Madeddu P, Emanueli C. Nerve growth factor supplementation reverses the impairment, induced by Type 1 diabetes, of hindlimb post-ischaemic recovery in mice. Diabetologia. 2004 Jun;47(6):1055-63.
• Porcu P, Emanueli C, Desortes E, Marongiu GM, Piredda F, Chao L, Chao J, Madeddu P. Circulating tissue kallikrein levels correlate with severity of carotid atherosclerosis.  Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1104-10. Epub 2004 Apr 8.
• Graiani G, Emanueli C, Desortes E, Van Linthout S, Pinna A, Figueroa CD, Manni L, Madeddu P. Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice. Diabetologia. 2004;47:1047-54.
• Emanueli C, Graiani G, Salis MB, Gadau S, Desortes E, Madeddu P. Prophylactic gene therapy with human tissue kallikrein ameliorates limb ischemia recovery in type 1 diabetic mice. Diabetes. 2004;53:1096-103.
• Maestri R, Milia AF, Salis MB, Graiani G, Lagrasta C, Monica M, Corradi D, Emanueli C, Madeddu P. Cardiac hypertrophy and microvascular deficit in kinin B2 receptor knockout mice. Hypertension. 2003;41(5):1151-5.
• Emanueli C, Salis MB, Pinna A, Graiani G, Manni L, Madeddu P. Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs. Circulation. 2002 Oct 22;106(17):2257-62.
• Milia AF, Salis MB, Stacca T, Pinna A, Madeddu P, Trevisani M, Geppetti P, Emanueli C. Protease-activated receptor-2 stimulates angiogenesis and accelerates hemodynamic recovery in a mouse model of hindlimb ischemia. Circ Res. 2002 Aug 23;91(4):346-52.
• Emanueli C, Salis MB, Pinna A, Stacca T, Milia AF, Spano A, Chao J, Chao L, Sciola L, Madeddu P. Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer. Circulation. 2002 Aug 20;106(8):993-9.
• Emanueli C, Bonaria Salis M, Stacca T, Pintus G, Kirchmair R, Isner JM, Pinna A, Gaspa L, Regoli D, Cayla C, Pesquero JB, Bader M, Madeddu P. Targeting kinin B(1) receptor for therapeutic neovascularization. Circulation. 2002 Jan 22;105(3):360-6.
• Emanueli C, Salis MB, Stacca T, Pinna A, Gaspa L, Madeddu P. Angiotensin AT(1) receptor signalling modulates reparative angiogenesis induced by limb ischaemia. Br J Pharmacol. 2002 Jan;135(1):87-92.
• Porcu P, Emanueli C, Kapatsoris M, Chao J, Chao L, Madeddu P. Reversal of angiogenic growth factor upregulation by revascularization of lower limb ischemia. Circulation. 2002;105:67-72.
• Emanueli C, Salis MB, Stacca T, Gaspa L, Chao J, Chao L, Piana A, Madeddu P. Rescue of impaired angiogenesis in spontaneously hypertensive rats by intramuscular human tissue kallikrein gene transfer. Hypertension. 2001;38:136-41.
• Madeddu P, Vio CP, Straino S, Salis MB, Milia AF, Emanueli C. Renal phenotype of low kallikrein rats. Kidney Int. 2001;59:2233-42.
• Emanueli C, Minasi A, Zacheo A, Chao J, Chao L, Salis MB, Straino S, Tozzi MG, Smith R, Gaspa L, Bianchini G, Stillo F, Capogrossi MC, Madeddu P. Local delivery of human tissue kallikrein gene accelerates spontaneous angiogenesis in mouse model of hindlimb ischemia. Circulation. 2001;103:125-32.
• Emanueli C, Zacheo A, Minasi A, Chao J, Chao L, Salis MB, Stacca T, Straino S, Capogrossi MC, Madeddu P. Adenovirus-mediated human tissue kallikrein gene delivery induces angiogenesis in normoperfused skeletal muscle. Arterioscler Thromb Vasc Biol. 2000 Nov;20(11):2379-85.
• Gowdak LH, Poliakova L, Wang X, Kovesdi I, Fishbein KW, Zacheo A, Palumbo R, Straino S, Emanueli C, Marrocco-Trischitta M, Lakatta EG, Anversa P, Spencer RG, Talan M, Capogrossi MC. Adenovirus-mediated VEGF(121) gene transfer stimulates angiogenesis in normoperfused skeletal muscle and preserves tissue perfusion after induction of ischemia. Circulation. 2000 Aug 1;102(5):565-71.
• Emanueli C, Bonaria Salis M, Figueroa C, Chao J, Chao L, Gaspa L, Capogrossi MC, Madeddu P. Participation of kinins in the captopril-induced inhibition of intimal hyperplasia caused by interruption of carotid blood flow in the mouse. Br J Pharmacol. 2000 Jul;130(5):1076-82
• Emanueli C, Salis MB, Chao J, Chao L, Agata J, Lin KF, Munaò A, Straino S, Minasi A, Capogrossi MC, Madeddu P. Adenovirus-mediated human tissue kallikrein gene delivery inhibits neointima formation induced by interruption of blood flow in mice. Arterioscler Thromb Vasc Biol. 2000;20:1459-66.
• Madeddu P, Emanueli C, Maestri R, Salis MB, Minasi A, Capogrossi MC, Olivetti G. Angiotensin II type 1 receptor blockade prevents cardiac remodeling in bradykinin B(2) receptor  knockout mice. Hypertension. 2000;35:391-6.
• Emanueli C, Maestri R, Corradi D, Marchione R, Minasi A, Tozzi MG, Salis MB, Straino S, Capogrossi MC, Olivetti G, Madeddu P. Dilated and failing cardiomyopathy in bradykinin B(2) receptor knockout mice. Circulation. 1999 Dec 7;100(23):2359-65.
• Emanueli C, Chao J, Regoli D, Chao L, Ni A, Madeddu P. The bradykinin B1 receptor and the central regulation of blood pressure in spontaneously hypertensive rats. Br J Pharmacol. 1999 Apr;126(8):1769-76.
• Madeddu P, Salis MB, Milia AF, Emanueli C, Guerrini R, Regoli D, Calò G. Cardiovascular effects of nociceptin in unanesthetized mice. Hypertension.1999;33:914-9.
• Emanueli C, Ricciardolo F, Vergnani L, Bertrand C, Ricci F, Manzoli N, Folkerts G, Nijkamp FP, Geppetti P. Characterization of the endothelin receptor subtype mediating epithelium-derived relaxant nitric oxide release from guinea-pig trachea. Br J Pharmacol. 1998;125:963-8.
• Madeddu P, Milia AF, Salis MB, Gaspa L, Gross W, Lippoldt A, Emanueli C. Renovascular hypertension in bradykinin B2-receptor knockout mice. Hypertension. 1998;32:503-9.
• Emanueli C, Grady EF, Madeddu P, Figini M, Bunnett NW, Parisi D, Regoli D, Geppetti P. Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P. Hypertension. 1998 Jun;31(6):1299-304.
• Emanueli C, Fink E, Milia AF, Salis MB, Conti M, Demontis MP, Madeddu P. Enhanced blood pressure sensitivity to deoxycorticosterone in mice with disruption of bradykinin B2 receptor gene. Hypertension. 1998 Jun;31(6):1278-83.
• Demontis MP, Varoni MV, Volpe AR, Emanueli C, Madeddu P. Role of nitric oxide synthase inhibition in the acute hypertensive response to intracerebroventricular cadmium. Br J Pharmacol. 1998;123:129-35.
• Madeddu P, Varoni MV, Palomba D, Emanueli C, Demontis MP, Glorioso N, Dessì-Fulgheri P, Sarzani R, Anania V. Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene. Circulation. 1997 Nov 18;96(10):3570-8.
• Emanueli C, Angioni GR, Anania V, Spissu A, Madeddu P. Blood pressure responses to acute or chronic captopril in mice with disruption of bradykinin B2-receptor gene. J Hypertens. 1997;15:1701-6.
• Madeddu P, Emanueli C, Song Q, Varoni MV, Demontis MP, Anania V, Glorioso N, Chao J. Regulation of bradykinin B2-receptor expression by oestrogen. Br J Pharmacol. 1997;121:1763-9.
• Yoshihara S, Nadel JA, Figini M, Emanueli C, Pradelles P, Geppetti P. Endogenous nitric oxide inhibits bronchoconstriction induced by cold-air inhalation in guinea pigs: role of kinins. Am J Respir Crit Care Med. 1998;157:547-52.
• Figini M, Emanueli C, Bertrand C, Sicuteri R, Regoli D, Geppetti P. Differential activation of the epithelial and smooth muscle NK1 receptors by synthetic tachykinin agonists in guinea-pig trachea. Br J Pharmacol. 1997;121:773-81.
• Figini M, Emanueli C, Grady EF, Kirkwood K, Payan DG, Ansel J, Gerard C, Geppetti P, Bunnett N. Substance P and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas. Am J Physiol. 1997;272:G785-93.
• Lu B, Figini M, Emanueli C, Geppetti P, Grady EF, Gerard NP, Ansell J, Payan DG, Gerard C, Bunnett N. The control of microvascular permeability and blood pressure by neutral endopeptidase. Nat Med. 1997 Aug;3(8):904-7.
• Figini M, Emanueli C, Bertrand C, Javdan P, Geppetti P. Evidence that tachykinins relax the guinea-pig trachea via nitric oxide release and by stimulation of a septide-insensitive NK1 receptor. Br J Pharmacol. 1996;117:1270-6.
• Figini M, Ricciardolo FL, Javdan P, Nijkamp FP, Emanueli C, Pradelles P, Folkerts G, Geppetti P. Evidence that epithelium-derived relaxing factor released by bradykinin in the guinea pig trachea is nitric oxide. Am J Respir Crit Care Med. 1996;153:918-23.
• Javdan P, Figini M, Emanueli C, Geppetti P. Nedocromil sodium reduces allergen-induced plasma extravasation in the guinea pig nasal mucosa by inhibition of tachykinin release. Allergy. 1995;50:825-9.

SELECTED PEER-REVIEWED REVIEW ARTICLES

 

• Kane NM,  Thrasher AJ ,  Angelini GD,  Emanueli C. MicroRNAs as modulators of Stem Cells and Angiogenesis (review) Stem Cells  2014 Jan 21. [Epub ahead of print]
• Emanueli C, Meloni M, Hasan W, Habecker BA. The biology of neurotrophins: cardiovascular function. Handb Exp Pharmacol. 2014;220:309-28.
• Zhang C, Zeng L, Emanueli C, Xu Q. Blood flow and stem cells in vascular disease. Cardiovasc Res. 2013 Jul 15;99(2):251-9.
• Descamps B, Emanueli C. Vascular differentiation from embryonic stem cells: novel technologies and therapeutic promises. Vascul Pharmacol. 2012;56:267-79. Review.
• Caporali A, Emanueli C. MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis. Trends Cardiovasc Med. 2011 Aug;21(6):162-6.
• Mitić T, Emanueli C. Diabetes-induced epigenetic signature in vascular cells. Endocr Metab Immune Disord Drug Targets. 2012;12:107-17. Review.
• Caporali A, Emanueli C. MicroRNAs in Postischemic Vascular Repair. Cardiol Res Pract. 2012;2012:486702.
• Shantikumar S, Caporali A, Emanueli C. Role of microRNAs in diabetes and its cardiovascular complications. Cardiovasc Res. 2012;93:583-93.
• Caporali A, Emanueli C. MicroRNA regulation in angiogenesis. Vascul Pharmacol. 2011;55:79-86.
• Kane NM, Xiao Q, Baker AH, Luo Z, Xu Q, Emanueli C. Pluripotent stem cell differentiation into vascular cells: a novel technology with promises for vascular re(generation). Pharmacol Ther. 2011;129:29-49.
• Caporali A, Emanueli C. Cardiovascular actions of neurotrophins. Physiol Rev. 2009 Jan;89(1):279-308. Review.
• Cristofaro B, Emanueli C. Possible novel targets for therapeutic angiogenesis. Curr Opin Pharmacol. 2009;9:102-8.
• Spinetti G, Kraenkel N, Emanueli C, Madeddu P. Diabetes and vessel wall remodelling: from mechanistic insights to regenerative therapies. Cardiovasc Res. 2008;78:265-73.
• Madeddu P, Emanueli C, El-Dahr S. Mechanisms of disease: the tissue kallikrein-kinin system in hypertension and vascular remodeling. Nat Clin Pract Nephrol. 2007;3:208-21.
• Madeddu P, Emanueli C, Spillmann F, Meloni M, Bouby N, Richer C, Alhenc-Gelas F, Van Weel V, Eefting D, Quax PH, Hu Y, Xu Q, Hemdahl AL, van Golde J, Huijberts M, de Lussanet Q, Struijker Boudier H, Couffinhal T, Duplaa C, Chimenti S, Staszewsky L, Latini R, Baumans V, Levy BI. Murine models of myocardial and limb ischemia: diagnostic end-points and relevance to clinical problems. Vascul Pharmacol. 2006;45:281-301.
• Emanueli C, Madeddu P. Therapeutic angiogenesis: translating experimental concepts to medically relevant goals. Vascul Pharmacol. 2006;45:334-9.
• Emanueli C, Lako M, Stojkovic M, Madeddu P. In search of the best candidate for regeneration of ischemic tissues: are embryonic/fetal stem cells more advantageous than adult counterparts? Thromb Haemost. 2005;94:738-49.
• Semplicini A, Amodio P, Leonetti G, Cuspidi C, Umiltà C, Schiff S, Scheltens P, Barkhof F, Emanueli C, Cagnin A, Pizzolato G, Macchini L, Realdi A, Royter V, Bornstein NM, Madeddu P. Diagnostic tools for the study of vascular cognitive dysfunction in hypertension and antihypertensive drug research. Pharmacol Ther. 2006;109:274-83.
• Emanueli C, Madeddu P. Changing the logic of therapeutic angiogenesis for ischemic disease. Trends Mol Med. 2005;11:207-16.
• Alessandri G, Emanueli C, Madeddu P. Genetically engineered stem cell therapy for tissue regeneration. Ann N Y Acad Sci. 2004;1015:271-84.
• Emanueli C, Schratzberger P, Kirchmair R, Madeddu P. Paracrine control of vascularization and neurogenesis by neurotrophins. Br J Pharmacol. 2003;140:614-9.
• Emanueli C, Madeddu P. Targeting kinin receptors for the treatment of tissue ischaemia. Trends Pharmacol Sci. 2001;22:478-84.
• Emanueli C, Madeddu P. Angiogenesis gene therapy to rescue ischaemic tissues: achievements and future directions. Br J Pharmacol. 2001;133:951-8.

 

SELECTED INVITED COMMENTARIES

• Shantikumar S, Angelini GD, Emanueli C. Diabetes, microRNAs and exosomes: Les liaisons dangereuses. J Mol Cell Cardiol. 2014 Sep;74:196-8.
• Emanueli C, Thum T. miRNAGE-34 induces cardiac damAGE. Cell Res. 2013 Jul;23(7):866-7.
• Emanueli C, Kränkel N. You can teach an old dog new tricks: angiopoietin-1 instructs Tie2(pos) myeloid cells to promote neovascularization in ischemic limbs. EMBO Mol Med. 2013 Jun;5(6):802-4.
• Descamps B, Madeddu P, Emanueli C. S100A1: A novel and essential molecular component for postischemic angiogenesis. Circ Res. 2013 Jan 4;112(1):3-5.

 

 

 

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