Imperial College London
Portrait Picture

Professor Costanza Emanueli

Faculty of Medicine, National Heart & Lung Institute

Chair in Cardiovascular Science
 
 
 
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Contact

 

c.emanueli Website

 
 
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Location

 

434ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

279 results found

Mitic T, Caporali A, Floris I, Meloni M, Marchetti M, Urrutia R, Angelini GD, Emanueli Cet al., 2015, EZH2 Modulates Angiogenesis <i>In Vitro</i> and in a Mouse Model of Limb Ischemia, MOLECULAR THERAPY, Vol: 23, Pages: 32-42, ISSN: 1525-0016

Journal article

Spencer HL, Slater SC, Rowlinson J, Morgan T, Culliford LA, Guttridge M, Emanueli C, Angelini G, Madeddu Pet al., 2015, A journey from basic stem cell discovery to clinical application: the case of adventitial progenitor cells, REGENERATIVE MEDICINE, Vol: 10, Pages: 39-47, ISSN: 1746-0751

Journal article

Mushtaq S, Ali T, Gul M, Javed Q, Emanueli C, Murtaza Iet al., 2015, Insulin Over Expression induces Heart Abnormalities via Reactive Oxygen Species Regulation, might be step towards Cardiac Hypertrophy, CELLULAR AND MOLECULAR BIOLOGY, Vol: 61, Pages: 30-35, ISSN: 0145-5680

Journal article

Caputo M, Skerritt C, Emanueli C, 2015, Circulating MicroRNAs as New Biomarkers of Ischaemia/Reperfusion Injury during Cardiac Surgery, CARDIOLOGY, Vol: 130, Pages: 234-236, ISSN: 0008-6312

Journal article

Saif J, Emanueli C, 2014, miRNAs in post-ischaemic angiogenesis and vascular remodelling, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 42, Pages: 1629-1636, ISSN: 0300-5127

Journal article

Shantikumar S, Angelini GD, Emanueli C, 2014, Diabetes, microRNAs and exosomes: Les liaisons dangereuses, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 74, Pages: 196-198, ISSN: 0022-2828

Journal article

Avolio E, Gianfranceschi G, Cesselli D, Caragnano A, Athanasakis E, Katare R, Meloni M, Palma A, Barchiesi A, Vascotto C, Toffoletto B, Mazzega E, Finato N, Aresu G, Livi U, Emanueli C, Scoles G, Beltrami CA, Madeddu P, Beltrami APet al., 2014, Ex Vivo Molecular Rejuvenation Improves the Therapeutic Activity of Senescent Human Cardiac Stem Cells in a Mouse Model of Myocardial Infarction, STEM CELLS, Vol: 32, Pages: 2373-2385, ISSN: 1066-5099

Journal article

Boin F, Erre GL, Posadino AM, Cossu A, Giordo R, Spinetti G, Passiu G, Emanueli C, Pintus Get al., 2014, Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension, ORPHANET JOURNAL OF RARE DISEASES, Vol: 9, ISSN: 1750-1172

Journal article

Caporali A, Meloni M, Mitic T, Nailor A, Emanueli Cet al., 2014, p75NTR-dependent activation of NF-kB is required for the trafficking and transcriptional regulation of microRNA-503 in microvascular complications of diabetes, 3rd Congress of the ESC-Council-on-Basic-Cardiovascular-Science on Frontiers in Cardio Vascular Biology, Publisher: OXFORD UNIV PRESS, ISSN: 0008-6363

Conference paper

Reni C, Mangialardi G, Meloni M, Emanueli C, Madeddu Pet al., 2014, Osteoclasts activation contributes to remodeling of the stem cell niche in diabetes, 3rd Congress of the ESC-Council-on-Basic-Cardiovascular-Science on Frontiers in Cardio Vascular Biology, Publisher: OXFORD UNIV PRESS, ISSN: 0008-6363

Conference paper

Machado MJC, Stone OA, Carter JG, Lin PC, Paleolog E, Emanueli C, Bates DOet al., 2014, Differential regulation of neovascularisation and mural cell recruitment by VEGF and angiopoietin signaling, Publisher: SPRINGER, Pages: 759-759, ISSN: 0969-6970

Conference paper

Kane NM, Thrasher AJ, Angelini GD, Emanueli Cet al., 2014, Concise Review: MicroRNAs as Modulators of Stem Cells and Angiogenesis, STEM CELLS, Vol: 32, Pages: 1059-1066, ISSN: 1066-5099

Journal article

Spinetti G, Specchia C, Fortunato O, Sangalli E, Clerici G, Caminiti M, Airoldi F, Losa S, Emanueli C, Faglia E, Madeddu Pet al., 2014, Migratory Activity of Circulating Mononuclear Cells Is Associated With Cardiovascular Mortality in Type 2 Diabetic Patients With Critical Limb Ischemia, DIABETES CARE, Vol: 37, Pages: 1410-1417, ISSN: 0149-5992

Journal article

Moore A, Shindikar A, Fomison-Nurse I, Riu F, Munasinghe PE, Ram TP, Saxena P, Coffey S, Bunton RW, Galvin IF, Williams MJA, Emanueli C, Madeddu P, Katare Ret al., 2014, Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1, CARDIOVASCULAR DIABETOLOGY, Vol: 13, ISSN: 1475-2840

Journal article

Emanueli C, Meloni M, Hasan W, Habecker BAet al., 2014, The biology of neurotrophins: cardiovascular function., Handb Exp Pharmacol, Vol: 220, Pages: 309-328, ISSN: 0171-2004

This chapter addresses the role of neurotrophins in the development of the heart, blood vessels, and neural circuits that control cardiovascular function, as well as the role of neurotrophins in the mature cardiovascular system. The cardiovascular system includes the heart and vasculature whose functions are tightly controlled by the nervous system. Neurons, cardiomyocytes, endothelial cells, vascular smooth muscle cells, and pericytes are all targets for neurotrophin action during development. Neurotrophin expression continues throughout life, and several common pathologies that impact cardiovascular function involve changes in the expression or activity of neurotrophins. These include atherosclerosis, hypertension, diabetes, acute myocardial infarction, and heart failure. In many of these conditions, altered expression of neurotrophins and/or neurotrophin receptors has direct effects on vascular endothelial and smooth muscle cells in addition to effects on nerves that modulate vascular resistance and cardiac function. This chapter summarizes the effects of neurotrophins in cardiovascular physiology and pathophysiology.

Journal article

Shantikumar S, Marchetti M, Caporali A, Howad L, Meloni M, Martelli F, Emanueli Cet al., 2013, The P75NTR-induced MicroRNA-30c-2*Impairs Endothelial Cell Survival and Angiogenesis, Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322

Conference paper

Leistner DM, Roexe T, Beiras A, Boeckel N, Lucas T, Noeh L, Burck I, Steiner LK, Emanueli C, Dimmeler S, Zeiher AMet al., 2013, Increased Pericardial Adipose Tissue Volume and its Association With Adverse Left Ventricular Remodeling: Does MiR-208a Release Into the Pericardial Space Provide a Mechanistic Link?, Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322

Conference paper

Mitic T, Anannya O, Emanueli C, 2013, Epigenetic Modulation of Endothelial Cell Responses to Hypoxia and Post-ischemic Angiogenesis by the Component of Polycomb Repressive Complex 2 (PRC2), Enhancer of Zest Homology (EZH2), Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322

Conference paper

Katare R, Riu F, Rowlinson J, Lewis A, Holden R, Meloni M, Reni C, Wallrapp C, Emanueli C, Madeddu Pet al., 2013, Perivascular Delivery of Encapsulated Mesenchymal Stem Cells Improves Postischemic Angiogenesis Via Paracrine Activation of VEGF-A, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 33, Pages: 1872-1880, ISSN: 1079-5642

Journal article

Zhang C, Zeng L, Emanueli C, Xu Qet al., 2013, Blood flow and stem cells in vascular disease, CARDIOVASCULAR RESEARCH, Vol: 99, Pages: 251-259, ISSN: 0008-6363

Journal article

Emanueli C, Thum T, 2013, miRNAGE-34 induces cardiac damAGE, CELL RESEARCH, Vol: 23, Pages: 866-867, ISSN: 1001-0602

Journal article

Meloni M, Marchetti M, Garner K, Littlejohns B, Sala-Newby G, Xenophontos N, Floris I, Suleiman M-S, Madeddu P, Caporali A, Emanueli Cet al., 2013, Local Inhibition of MicroRNA-24 Improves Reparative Angiogenesis and Left Ventricle Remodeling and Function in Mice With Myocardial Infarction, MOLECULAR THERAPY, Vol: 21, Pages: 1390-1402, ISSN: 1525-0016

Journal article

Emanueli C, Kraenkel N, 2013, You can teach an old dog new tricks: angiopoietin-1 instructs Tie2pos myeloid cells to promote neovascularization in ischemic limbs, EMBO MOLECULAR MEDICINE, Vol: 5, Pages: 802-804, ISSN: 1757-4676

Journal article

Mangialardi G, Katare R, Oikawa A, Meloni M, Reni C, Emanueli C, Madeddu Pet al., 2013, Diabetes Causes Bone Marrow Endothelial Barrier Dysfunction by Activation of the RhoA-Rho-Associated Kinase Signaling Pathway, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 33, Pages: 555-+, ISSN: 1079-5642

Journal article

Spinetti G, Cordella D, Fortunato O, Sangalli E, Losa S, Gotti A, Carnelli F, Rosa F, Riboldi S, Sessa F, Avolio E, Beltrami AP, Emanueli C, Madeddu Pet al., 2013, Global Remodeling of the Vascular Stem Cell Niche in Bone Marrow of Diabetic Patients Implication of the microRNA-155/FOXO3a Signaling Pathway, CIRCULATION RESEARCH, Vol: 112, Pages: 510-+, ISSN: 0009-7330

Journal article

Spinetti G, Fortunato O, Caporali A, Shantikumar S, Marchetti M, Meloni M, Descamps B, Floris I, Sangalli E, Vono R, Faglia E, Specchia C, Pintus G, Madeddu P, Emanueli Cet al., 2013, MicroRNA-15a and MicroRNA-16 Impair Human Circulating Proangiogenic Cell Functions and Are Increased in the Proangiogenic Cells and Serum of Patients With Critical Limb Ischemia, CIRCULATION RESEARCH, Vol: 112, ISSN: 0009-7330

Journal article

Descamps B, Madeddu P, Emanueli C, 2013, S100A1: A Novel and Essential Molecular Component for Postischemic Angiogenesis, CIRCULATION RESEARCH, Vol: 112, Pages: 3-5, ISSN: 0009-7330

Journal article

Katare R, Oikawa A, Cesselli D, Beltrami AP, Avolio E, Muthukrishnan D, Munasinghe PE, Angelini G, Emanueli C, Madeddu Pet al., 2013, Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes, CARDIOVASCULAR RESEARCH, Vol: 97, Pages: 55-65, ISSN: 0008-6363

Journal article

Jazwa A, Stepniewski J, Zamykal M, Jagodzinska J, Meloni M, Emanueli C, Jozkowicz A, Dulak Jet al., 2013, Pre-emptive hypoxia-regulated HO-1 gene therapy improves post-ischaemic limb perfusion and tissue regeneration in mice, CARDIOVASCULAR RESEARCH, Vol: 97, Pages: 115-124, ISSN: 0008-6363

Journal article

Jazwa A, Tomczyk M, Taha HM, Hytonen E, Stoszko M, Zentilin L, Giacca M, Yla-Herttuala S, Emanueli C, Jozkowicz A, Dulak Jet al., 2013, Arteriogenic therapy based on simultaneous delivery of VEGF-A and FGF4 genes improves the recovery from acute limb ischemia., Vasc Cell, Vol: 5, ISSN: 2045-824X

BACKGROUND: Gene therapy stimulating the growth of blood vessels is considered for the treatment of peripheral and myocardial ischemia. Here we aimed to achieve angiogenic synergism between vascular endothelial growth factor-A (VEGF-A, VEGF) and fibroblast growth factor 4 (FGF4) in murine normoperfused and ischemic limb muscles. METHODS: Adeno-associated viral vectors (AAVs) carrying β-galactosidase gene (AAV-LacZ), VEGF-A (AAV-VEGF-A) or two angiogenic genes (AAV-FGF4-IRES-VEGF-A) were injected into the normo-perfused adductor muscles of C57Bl/6 mice. Moreover, in a different experiment, mice were subjected to unilateral hindlimb ischemia by femoral artery ligation followed by intramuscular injections of AAV-LacZ, AAV-VEGF-A or AAV-FGF4-IRES-VEGF-A below the site of ligation. Post-ischemic blood flow recovery was assessed sequentially by color laser Doppler. Mice were monitored for 28 days. RESULTS: VEGF-A delivered alone (AAV-VEGF-A) or in combination with FGF4 (AAV-FGF4-IRES-VEGF-A) increased the number of capillaries in normo-perfused hindlimbs when compared to AAV-LacZ. Simultaneous overexpression of both agents (VEGF-A and FGF4) stimulated the capillary wall remodeling in the non-ischemic model. Moreover, AAV-FGF4-IRES-VEGF-A faster restored the post-ischemic foot blood flow and decreased the incidence of toe necrosis in comparison to AAV-LacZ. CONCLUSIONS: Synergy between VEGF-A and FGF4 to produce stable and functional blood vessels may be considered a promising option in cardiovascular gene therapy.

Journal article

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