Imperial College London
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Professor Costanza Emanueli

Faculty of Medicine, National Heart & Lung Institute

Chair in Cardiovascular Science
 
 
 
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Contact

 

c.emanueli Website

 
 
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Location

 

434ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chen:2019:10.1038/s41467-019-11551-9,
author = {Chen, H and Moreno-Moral, A and Pesce, F and Devapragash, N and Mancini, M and Heng, E and Rotival, M and Srivastava, P and Harmston, N and Shkura, K and Rackham, O and Yu, W-P and Sun, X-M and Gui, Zhen Tee N and Tan, E and Barton, P and Felkin, L and Lara-Pezzi, E and Angelini, G and Beltrami, C and Pravenec, M and Schafer, S and Bottolo, L and Hubner, N and Emanueli, C and Cook, S and Petretto, E},
doi = {10.1038/s41467-019-11551-9},
journal = {Nature Communications},
pages = {1--19},
title = {WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling},
url = {http://dx.doi.org/10.1038/s41467-019-11551-9},
volume = {10},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that causes cardiac electrical and pump failure. Here, we use systems genetics to identify a pro-fibrotic gene network in the diseased heart and show that this network is regulated by the E3 ubiquitin ligase WWP2, specifically by the WWP2-N terminal isoform. Importantly, the WWP2-regulated pro-fibrotic gene network is conserved across different cardiac diseases characterized by fibrosis: human and murine dilated cardiomyopathy and repaired tetralogy of Fallot. Transgenic mice lacking the N-terminal region of the WWP2 protein show improved cardiac function and reduced myocardial fibrosis in response to pressure overload or myocardial infarction. In primary cardiac fibroblasts, WWP2 positively regulates the expression of pro-fibrotic markers and extracellular matrix genes. TGFβ1 stimulation promotes nuclear translocation of the WWP2 isoforms containing the N-terminal region and their interaction with SMAD2. WWP2 mediates the TGFβ1-induced nucleocytoplasmic shuttling and transcriptional activity of SMAD2.
AU  - Chen,H
AU  - Moreno-Moral,A
AU  - Pesce,F
AU  - Devapragash,N
AU  - Mancini,M
AU  - Heng,E
AU  - Rotival,M
AU  - Srivastava,P
AU  - Harmston,N
AU  - Shkura,K
AU  - Rackham,O
AU  - Yu,W-P
AU  - Sun,X-M
AU  - Gui,Zhen Tee N
AU  - Tan,E
AU  - Barton,P
AU  - Felkin,L
AU  - Lara-Pezzi,E
AU  - Angelini,G
AU  - Beltrami,C
AU  - Pravenec,M
AU  - Schafer,S
AU  - Bottolo,L
AU  - Hubner,N
AU  - Emanueli,C
AU  - Cook,S
AU  - Petretto,E
DO  - 10.1038/s41467-019-11551-9
EP  - 19
PY  - 2019///
SN  - 2041-1723
SP  - 1
TI  - WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-019-11551-9
UR  - https://www.nature.com/articles/s41467-019-11551-9
UR  - http://hdl.handle.net/10044/1/71614
VL  - 10
ER  -
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