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@article{Tikhomirov:2020:10.3390/cells9030592,
author = {Tikhomirov, R and Donnell, BR-O and Catapano, F and Faggian, G and Gorelik, J and Martelli, F and Emanueli, C},
doi = {10.3390/cells9030592},
journal = {Cells},
title = {Exosomes: From potential culprits to new therapeutic promise in the setting of cardiac fibrosis},
url = {http://dx.doi.org/10.3390/cells9030592},
volume = {9},
year = {2020}
}

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TY  - JOUR
AB  - Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease. Cardiac fibroblasts and myofibroblasts are the main effectors of ECM deposition and scar formation. The heart is a complex multicellular organ, where the various resident cell types communicate between themselves and with cells of the blood and immune systems. Exosomes, which are small extracellular vesicles, (EVs), contribute to cell-to-cell communication and their pathophysiological relevance and therapeutic potential is emerging. Here, we will critically review the role of endogenous exosomes as possible fibrosis mediators and discuss the possibility of using stem cell-derived and/or engineered exosomes as anti-fibrotic agents.
AU  - Tikhomirov,R
AU  - Donnell,BR-O
AU  - Catapano,F
AU  - Faggian,G
AU  - Gorelik,J
AU  - Martelli,F
AU  - Emanueli,C
DO  - 10.3390/cells9030592
PY  - 2020///
SN  - 2073-4409
TI  - Exosomes: From potential culprits to new therapeutic promise in the setting of cardiac fibrosis
T2  - Cells
UR  - http://dx.doi.org/10.3390/cells9030592
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32131460
UR  - http://hdl.handle.net/10044/1/78134
VL  - 9
ER  -

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Professor Costanza Emanueli

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