Imperial College London
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Dr Claire Feeney

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

c.feeney

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jamall:2016:10.1111/cen.13045,
author = {Jamall, O and Feeney, C and Zaw-Linn, J and Malik, A and Niemi, M and Tenorio-Jimenez, C and Ham, TE and Jilka, SR and Jenkins, PO and Scott, G and Li, LM and Gorgoraptis, N and Baxter, D and Sharp, DJ and Goldstone, AP},
doi = {10.1111/cen.13045},
journal = {Clinical Endocrinology},
pages = {636--644},
title = {Prevalence and correlates of vitamin D deficiency in adults after traumatic brain injury},
url = {http://dx.doi.org/10.1111/cen.13045},
volume = {85},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives: Traumatic brain injury (TBI) is a major cause of long-term disability with variable recovery. Preclinicalstudies suggest that vitamin D status influences recovery after TBI. However, there is no publishedclinical data on links between vitamin D status and TBI outcomes. To determine the: (i) prevalence ofvitamin D deficiency/insufficiency, and associations of vitamin D status with (ii) demographic factors andTBI severity, and with (iii) cognitive function, symptoms and quality of life, in adults after TBI.Design: Retrospective audit of patients seen between July 2009 and March 2015. Serum vitamin D (25-hydroxy-cholecalciferol) was categorised as deficient (<40nmol/L), insufficient (40-70nmol/L) or replete(>70nmol/L).Patients: 353 adults seen in tertiary hospital clinic (75.4% lighter-skinned, 74.8% male, age median 35.1y,range 26.6-48.3y), 0.3-56.5 months after TBI (74.5% moderate-severe).Measurements: Serum vitamin D concentrations; Addenbrooke’s Cognitive Examination (ACE-R), BeckDepression Inventory II (BDI-II), SF-36 Quality of Life, Pittsburgh Sleep Quality Index.Results: 46.5% of patients after TBI had vitamin D deficiency and 80.2% insufficiency/deficiency. Patientswith vitamin D deficiency had lower ACE-R scores than those vitamin D replete (mean effect size ± SEM 4.5± 2.1, P=0.034), and higher BDI-II scores than those vitamin D insufficient (4.5 ± 1.6, P=0.003), correcting forage, gender, time since TBI, TBI severity. There was no association between vitamin D status and markers ofTBI severity, sleep or quality of life.Conclusion: Vitamin D deficiency is common in patients after TBI and associated with impaired cognitivefunction and more severe depressive symptoms.
AU  - Jamall,O
AU  - Feeney,C
AU  - Zaw-Linn,J
AU  - Malik,A
AU  - Niemi,M
AU  - Tenorio-Jimenez,C
AU  - Ham,TE
AU  - Jilka,SR
AU  - Jenkins,PO
AU  - Scott,G
AU  - Li,LM
AU  - Gorgoraptis,N
AU  - Baxter,D
AU  - Sharp,DJ
AU  - Goldstone,AP
DO  - 10.1111/cen.13045
EP  - 644
PY  - 2016///
SN  - 1365-2265
SP  - 636
TI  - Prevalence and correlates of vitamin D deficiency in adults after traumatic brain injury
T2  - Clinical Endocrinology
UR  - http://dx.doi.org/10.1111/cen.13045
UR  - http://hdl.handle.net/10044/1/29828
VL  - 85
ER  -
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