Publications
414 results found
Newton C, Nordin A, Rolland P, et al., 2020, British Gynaecological Cancer Society recommendations and guidance on patient-initiated follow-up (PIFU), INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 30, Pages: 695-700, ISSN: 1048-891X
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- Citations: 28
Avesani G, Arshad M, Lu H, et al., 2020, Radiological assessment of Peritoneal Cancer Index on preoperative CT in ovarian cancer is related to surgical outcome and survival, La Radiologia Medica, Vol: 125, Pages: 770-776, ISSN: 0033-8362
PurposeTo evaluate whether Peritoneal Cancer Index (PCI) assessed on preoperative CT (CT-PCI) can be used as non-invasive preoperative tool to predict surgical outcome, disease-free survival (DFS) and overall survival (OS).Materials and methodsThis is a retrospective, observational cohort study performed in a single institution. We considered all patients with diagnosis of ovarian cancer and preoperative CT, who had undergone upfront cytoreductive surgery between 2008 and 2010 and had post-operative clinical follow-up to December 2015. Two radiologists reviewed CT scans and assessed CT-PCI using Sugarbaker’s diagram. We assessed the discriminatory capacity of the CT-PCI score on the surgical outcome by ROC curve analysis. DFS and OS were assessed by Kaplan–Meier nonparametric curves and by multivariable Cox-regression analysis.ResultsA total of 297 patients were included in the present analysis. CT-PCI was positively correlated with post-operative residual disease [odds ratio (OR) 1.04, 95% CI 1.01–1.07, p = 0.003]. ROC curve analysis returned AUC = 0.64 for the prediction of total macroscopic tumour clearance. In multivariable analysis, patients with no peritoneal disease seen on CT had a significantly longer DFS [Hazard ratio (HR) 2.28, p = 0.007]. Radiological serosal small bowel involvement was an independent predictor for shorter OS (HR 3.01, p = 0.002).ConclusionRadiological PCI assessed on preoperative CT is associated with the probability of residual disease after cytoreductive surgery; however, it has low performance as a triage test to reliably identify patients who are likely to have complete cytoreductive surgery. CT-PCI is positively correlated with both DFS and OS and may be used as an independent prognostic factor, for example in patients with high FIGO stages.
Bizzarri N, Razumova Z, Selcuk I, et al., 2020, Report from the 21st meeting of the European Society of Gynaecological Oncology (ESGO 2019), INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 30, Pages: 441-447, ISSN: 1048-891X
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- Citations: 3
Sabini C, Sorbi F, Cunnea P, et al., 2020, Ovarian cancer stem cells: ready for prime time?, ARCHIVES OF GYNECOLOGY AND OBSTETRICS, Vol: 301, Pages: 895-899, ISSN: 0932-0067
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- Citations: 7
Fotopoulou C, Concin N, Planchamp F, et al., 2020, Quality indicators for advanced ovarian cancer surgery from the European Society of Gynaecological Oncology (ESGO): 2020 update, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 30, Pages: 436-440, ISSN: 1048-891X
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- Citations: 50
Fotopoulou C, 2020, How to predict treatment failure in frail patients with advanced epithelial ovarian cancer: strategies to personalize surgical effort, JOURNAL OF GYNECOLOGIC ONCOLOGY, Vol: 31, ISSN: 2005-0380
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- Citations: 2
Querleu D, Cibula D, Concin N, et al., 2020, Laparoscopic radical hysterectomy: a European Society of Gynaecological Oncology (ESGO) statement, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 30, Pages: 15-15, ISSN: 1048-891X
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- Citations: 35
Cibula D, Planchamp F, Fischerova D, et al., 2020, European Society of Gynaecological Oncology quality indicators for surgical treatment of cervical cancer, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 30, Pages: 3-14, ISSN: 1048-891X
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- Citations: 28
Fotopoulou C, Berg T, Hausen A, et al., 2019, Continuous low flow ascites drainage through the urinary bladder via the Alfapump system in palliative patients with malignant ascites., BMC Palliat Care, Vol: 18
BACKGROUND: Malignant Ascites (MA) is a therapeutic dilemma significantly impairing patients' quality of life (QoL). The Sequana Medical alfapump System (AP), a subcutaneous, externally rechargeable, implantable device, continually draining ascites via the urinary bladder, has been well established in liver cirrhosis, but not yet in MA. The AP-system was evaluated in cancer patients in reducing the need for large volume paracentesis (LVP). METHODS: A retrospective multicentre evaluation of all eligible patients who received an AP for MA-palliation was performed. AP was evaluated for its ability to reduce LVP and cross-correlated with adverse events (AE), survival and retrospective physician-reported QoL. RESULTS: Seventeen patients with median age of 63 years (range: 18-81), 70.6% female, across 7 primary tumour types were analysed. Median duration of AP-implantation was 60 min (range: 30-270) and median post-implantation hospital stay: 4 days (range: 2-24). Twelve protocol-defined AE occurred in 5 patients (29.4%): 4 kidney failures, 4 pump/catheter-related blockages, 3 infections/peritonitis and 1 wound dehiscence. Median ascitic volume (AV) pumped daily was 303.6 ml/day (range:5.6-989.3) and median total AV drained was 28 L (range: 1-638.6). Median patient post-AP-survival was 111 days (range:10-715) and median pump survival was 89 days (range: 0-715). Median number of paracenteses was 4 (range: 1-15) per patient pre-implant versus 1 (range: 0-1) post-implant (p = 0.005). 71% of patients were reported to have an improvement of at least one physician reported QoL-parameters. CONCLUSIONS: AP appears to be effective in palliating patients with MA by an acceptable morbidity profile. Its broader implementation in oncology services should be further explored. TRIAL REGISTRATION: NCT03200106; June 27, 2017.
Fotopoulou C, Berg T, Hausen A, et al., 2019, Continuous low flow ascites drainage through the urinary bladder via the Alfapump system in palliative patients with malignant ascites, Publisher: BMC, Pages: 678-678, ISSN: 1472-684X
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- Citations: 5
Fotopoulou C, 2019, ASO Author Reflections: Value of Cytoreduction in Extensive Ovarian Cancer—Does Surgical Effort Still Matter?, Annals of Surgical Oncology, Vol: 26, Pages: 786-787, ISSN: 1068-9265
Fotopoulou C, Hall M, 2019, Reply to "Denominator-Based Studies Need Full Disclosure of the Origins of Patients Treated'', ANNALS OF SURGICAL ONCOLOGY, Vol: 26, Pages: S874-S875, ISSN: 1068-9265
Lathouras K, Panagakis G, Bowden S, et al., 2019, DIAGNOSTIC VALUE OF POSTOPERATIVE PLATELET-TO-WHITE BLOOD CELL RATIO (PC/WCC) AFTER SPLENECTOMY IN ADVANCED OVARIAN CANCER PATIENTS, Publisher: BMJ PUBLISHING GROUP, Pages: A485-A486, ISSN: 1048-891X
Rinne N, Curry E, Fotopoulou C, et al., 2019, TARGETING AKT AND DNA-PK AS A THERAPEUTIC STRATEGY IN PLATINUM RESISTANT HIGH-GRADE SEROUS OVARIAN CANCER, Publisher: BMJ PUBLISHING GROUP, Pages: A512-A513, ISSN: 1048-891X
Sundar S, Cummins C, Kumar S, et al., 2019, QUALITY OF LIFE AFTER SURGERY OF VARYING SURGICAL COMPLEXITY IN ADVANCED OVARIAN CANCER: RESULTS FROM THE INTERNATIONAL, PROSPECTIVE, MULTICENTER COHORT SOCQER2 STUDY, Publisher: BMJ PUBLISHING GROUP, Pages: A638-A639, ISSN: 1048-891X
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- Citations: 2
Lago V, Fotopoulou C, Chiantera V, et al., 2019, RISK FACTORS FOR ANASTOMOTIC LEAKAGE AFTER COLORECTAL RESECTION IN OVARIAN CANCER SURGERY: A MULTI-CENTRE STUDY, Publisher: BMJ PUBLISHING GROUP, Pages: A141-A141, ISSN: 1048-891X
Fotopoulou C, Ind T, Baldwin P, et al., 2019, Sentinel lymph node consensus document of the British Gynaecological Cancer Society for endometrial, vulvar, and cervical cancers, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 29, Pages: 1348-1350, ISSN: 1048-891X
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- Citations: 11
Urkmez E, Andac-Jones E, Cibula D, et al., 2019, Perceptions, expectations, and experiences of gynecological cancer patients: a pan-European ESGO-ENGAGe survey, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 29, Pages: 1425-1430, ISSN: 1048-891X
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- Citations: 5
Chekerov R, Braicu I, Fotopoulou C, et al., 2019, THE IMPACT OF UROLOGICAL COMPLICATIONS DURING SURGICAL TREATMENT FOR ADVANCED OVARIAN CANCER, Publisher: BMJ PUBLISHING GROUP, Pages: A451-A451, ISSN: 1048-891X
Cunnea P, Curry E, Nixon K, et al., 2019, MOLECULAR AND PHENOTYPIC CHARACTERISATION OF INTRA-TUMOURAL HETEROGENEITY IN HIGH GRADE SEROUS OVARIAN CANCER, Publisher: BMJ PUBLISHING GROUP, Pages: A50-A51, ISSN: 1048-891X
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- Citations: 1
Nixon K, Curry E, Wulandari R, et al., 2019, USE OF 3D ORGANOTYPIC MODELS TO ASSESS HETEROGENEITY IN RESPONSE TO PLATINUM THERAPY IN HIGH GRADE SEROUS OVARIAN CANCER, Publisher: BMJ PUBLISHING GROUP, Pages: A145-A145, ISSN: 1048-891X
Macintyre G, Goranova TE, De Silva D, et al., 2019, COPY-NUMBER SIGNATURES AND MUTATIONAL PROCESSES IN HIGH GRADE SEROUS OVARIAN CARCINOMA, 12th Rivkin-Centre Biennial Ovarian Cancer Research Symposium, Publisher: AMER ASSOC CANCER RESEARCH, Pages: 64-64, ISSN: 1078-0432
Reuss A, du Bois A, Harter P, et al., 2019, TRUST: Trial of Radical Upfront Surgical Therapy in advanced ovarian cancer (ENGOT ov33/AGO-OVAR OP7), INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 29, Pages: 1327-1331, ISSN: 1048-891X
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- Citations: 90
Lathouras K, Panagakis G, Bowden SJ, et al., 2019, Diagnostic value of post-operative platelet-to-white blood cell ratio after splenectomy in patients with advanced ovarian cancer, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 29, Pages: 1292-1297, ISSN: 1048-891X
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- Citations: 10
Salvo G, Ramirez PT, Wu X, et al., 2019, OPEN VS. MINIMALLY INVASIVE RADICAL TRACHELECTOMY IN EARLY STAGE CERVICAL CANCER: INTERNATIONAL MULTICENTER IRTA STUDY RESULTS, Publisher: BMJ PUBLISHING GROUP, Pages: A13-A14, ISSN: 1048-891X
Hall M, Savvatis K, Nixon K, et al., 2019, Maximal-effort cytoreductive surgery for ovarian cancer patients with a high tumor burden: variations in practice and impact on outcome, Annals of Surgical Oncology, Vol: 26, Pages: 2943-2951, ISSN: 1068-9265
BackgroundThis study aimed to compare the outcomes of two distinct patient populations treated within two neighboring UK cancer centers (A and B) for advanced epithelial ovarian cancer (EOC).MethodsA retrospective analysis of all new stages 3 and 4 EOC patients treated between January 2013 and December 2014 was performed. The Mayo Clinic surgical complexity score (SCS) was applied. Cox regression analysis identified the impact of treatment methods on survival.ResultsThe study identified 249 patients (127 at center A and 122 in centre B) without significant differences in International Federation of Gynecology and Obstetrics (FIGO) stage (FIGO 4, 29.7% at centers A and B), Eastern Cooperative Oncology Group (ECOG) performance status (ECOG < 2, 89.9% at centers A and B), or histology (serous type in 84.1% at centers A and B). The patients at center A were more likely to undergo surgery (87% vs 59.8%; p < 0.001). The types of chemotherapy and the patients receiving palliative treatment alone were equivalent between the two centers (3.6%). The median SCS was significantly higher at center A (9 vs 2; p < 0.001) with greater tumor burden (9 vs 6 abdominal fields involved; p < 0.001), longer median operation times (285 vs 155 min; p < 0.001), and longer hospital stays (9 vs 6 days; p < 0.001), but surgical morbidity and mortality were equivalent. The independent predictors of reduced overall survival (OS) were non-serous histology (hazard ratio [HR], 1.6; 95% confidence interval [CI] 1.04–2.61), ECOG higher than 2 (HR, 1.9; 95% CI 1.15–3.13), and palliation alone (HR, 3.43; 95% CI 1.51–7.81). Cytoreduction, of any timing, had an independent protective impact on OS compared with chemotherapy alone (HR, 0.31 for interval surgery and 0.39 for primary surgery), even after adjustment for other prognostic factors.ConclusionsIncorporating surgery into the initia
Fotopoulou CM, Dasyra KM, Combes F, et al., 2019, Complex molecular gas kinematics in the inner 5 kpc of 4C12.50 as seen by ALMA, ASTRONOMY & ASTROPHYSICS, Vol: 629, ISSN: 1432-0746
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- Citations: 9
Bellini MI, Adair A, Fotopoulou C, et al., 2019, Changing the norm towards gender equity in surgery: the women in surgery working group of the Association of Surgeons of Great Britain and Ireland's perspective, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 112, Pages: 325-329, ISSN: 0141-0768
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- Citations: 12
Lago V, Fotopoulou C, Chiantera V, et al., 2019, Risk factors for anastomotic leakage after colorectal resection in ovarian cancer surgery: A multi-centre study, GYNECOLOGIC ONCOLOGY, Vol: 153, Pages: 549-554, ISSN: 0090-8258
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- Citations: 33
Rinne N, Curry E, Fotopoulou C, et al., 2019, Targeting AKT and DNA-PK as a therapeutic strategy in platinum-resistant high-grade serous ovarian cancer, Publisher: WILEY, Pages: 88-89, ISSN: 1470-0328
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