Publications
414 results found
Lu H, Arshad M, Thornton A, et al., 2019, A mathematical descriptor of tumour mesoscopic structure from computed tomography images annotates prognostic and molecular phenotypes of epithelial ovarian cancer, Publisher: WILEY, Pages: 89-89, ISSN: 1470-0328
Nixon K, Wulandari R, Curry E, et al., 2019, Describing intratumoural heterogeneity in high-grade serous ovarian cancer, Publisher: WILEY, Pages: 87-88, ISSN: 1470-0328
Rinne N, Malune ME, Nixon K, et al., 2019, Radical ovarian cancer debulking surgery: colorectal anastomotic leak rates after primary end-to-end anastomosis without additional protective ileostomies, Publisher: WILEY, Pages: 86-86, ISSN: 1470-0328
Goranova T, Ennis D, Piskorz AM, et al., 2019, Correction: Safety and utility of image-guided research biopsies in relapsed high-grade serous ovarian carcinoma-experience of the BriTROC consortium., British Journal of Cancer, Vol: 120, ISSN: 0007-0920
This article was originally published under a CC BY NC SA License, but has now been made available under a CC BY 4.0 License.
Salvo G, Ramirez PT, Leitao M, et al., 2019, International radical trachelectomy assessment: IRTA study, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 29, Pages: 635-638, ISSN: 1048-891X
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- Citations: 29
Lu H, Arshad M, Thornton A, et al., 2019, A mathematical-descriptor of tumor-mesoscopic-structure from computed-tomography images annotates prognostic and molecular-phenotypes of epithelial ovarian cancer, Nature Communications, Vol: 10, ISSN: 2041-1723
The five-year survival rate of epithelial ovarian cancer (EOC) is approximately 35–40% despite maximal treatment efforts, highlighting a need for stratification biomarkers for personalized treatment. Here we extract 657 quantitative mathematical descriptors from the preoperative CT images of 364 EOC patients at their initial presentation. Using machine learning, we derive a non-invasive summary-statistic of the primary ovarian tumor based on 4 descriptors, which we name “Radiomic Prognostic Vector” (RPV). RPV reliably identifies the 5% of patients with median overall survival less than 2 years, significantly improves established prognostic methods, and is validated in two independent, multi-center cohorts. Furthermore, genetic, transcriptomic and proteomic analysis from two independent datasets elucidate that stromal phenotype and DNA damage response pathways are activated in RPV-stratified tumors. RPV and its associated analysis platform could be exploited to guide personalized therapy of EOC and is potentially transferrable to other cancer types.
Schmalfeldt B, Brambs C, Burges A, et al., 2019, What is the evidence for lymphadenectomy in presumed early ovarian cancer?, ARCHIVES OF GYNECOLOGY AND OBSTETRICS, Vol: 299, Pages: 1-5, ISSN: 0932-0067
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- Citations: 1
Ray-Coquard I, Trama A, Seckl MJ, et al., 2019, Rare ovarian tumours: Epidemiology, treatment challenges in and outside a network setting, EJSO, Vol: 45, Pages: 67-74, ISSN: 0748-7983
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- Citations: 18
Nasser S, Lathouras K, Nixon K, et al., 2018, Impact of right upper quadrant cytoreductive techniques with extensive liver mobilization on postoperative hepatic function and risk of liver failure in patients with advanced ovarian cancer, GYNECOLOGIC ONCOLOGY, Vol: 151, Pages: 466-470, ISSN: 0090-8258
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- Citations: 1
Harter P, du Bois A, Sehouli J, et al., 2018, Is there a role for HIPEC in ovarian cancer?, ARCHIVES OF GYNECOLOGY AND OBSTETRICS, Vol: 298, Pages: 859-860, ISSN: 0932-0067
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- Citations: 6
Cunnea P, Gorgy T, Petkos K, et al., 2018, Clinical value of bioelectrical properties of cancerous tissue in advanced epithelial ovarian cancer patients, Scientific Reports, Vol: 8, Pages: 1-12, ISSN: 2045-2322
Currently, there are no valid pre-operatively established biomarkers or algorithms that can accurately predict surgical and clinical outcome for patients with advanced epithelial ovarian cancer (EOC). In this study, we suggest that profiling of tumour parameters such as bioelectrical-potential and metabolites, detectable by electronic sensors, could facilitate the future development of devices to better monitor disease and predict surgical and treatment outcomes. Biopotential was recorded, using a potentiometric measurement system, in ex vivo paired non-cancerous and cancerous omental tissues from advanced stage EOC (n = 36), and lysates collected for metabolite measurement by microdialysis. Consistently different biopotential values were detected in cancerous tissue versus non-cancerous tissue across all cases (p < 0.001). High tumour biopotential levels correlated with advanced tumour stage (p = 0.048) and tumour load, and negatively correlated with stroma. Within our EOC cohort and specifically the high-grade serous subtype, low biopotential levels associated with poorer progression-free survival (p = 0.0179, p = 0.0143 respectively). Changes in biopotential levels significantly correlated with common apoptosis related pathways. Lactate and glucose levels measured in paired tissues showed significantly higher lactate/glucose ratio in tissues with low biopotential (p < 0.01, n = 12). Our study proposes the feasibility of biopotential and metabolite monitoring as a biomarker modality profiling EOC to predict surgical and clinical outcomes.
Ledermann JA, Raja FA, Fotopoulou C, et al., 2018, Corrections to "Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up"., Ann Oncol, Vol: 29 Suppl 4
Lathouras K, Saso S, Tzafetas M, et al., 2018, Genetic polymorphisms of matrix metalloproteinases 1-3 and their inhibitor are not associated with premature labor, FUTURE SCIENCE OA, Vol: 4, ISSN: 2056-5623
Ledermann JA, Raja FA, Fotopoulou C, et al., 2018, Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (vol 24, pg 24, 2013), ANNALS OF ONCOLOGY, Vol: 29, Pages: 259-259, ISSN: 0923-7534
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- Citations: 61
Lathouras K, Haidopoulos D, Lever S, et al., 2018, PC/WCC RATIO: A TOOL TO DIFFERENTIATE BETWEEN POSTOPERATIVE SEPSIS AND SPLENECTOMY INDUCED REACTIVE CHANGES AFTER RADICAL SURGERY FOR ADVANCED OR RELAPSED OVARIAN CANCER (OC) ?, Publisher: BMJ PUBLISHING GROUP, Pages: 680-680, ISSN: 1048-891X
Sundar S, Kumar S, Long J, et al., 2018, PATIENT REPORTED OUTCOMES (PRO) AFTER SURGERY IN ADVANCED OVARIAN CANCER - INITIAL RESULTS FROM THE INTERNATIONAL, PROSPECTIVE, MULTICENTER SOCQER 2 STUDY, Publisher: BMJ PUBLISHING GROUP, Pages: 604-606, ISSN: 1048-891X
Nasser S, Lathouras K, Nixon K, et al., 2018, IMPACT OF RIGHT UPPER QUADRANT CYTOREDUCTIVE TECHNIQUES WITH EXTENSIVE LIVER MOBILISATION ON POSTOPERATIVE HEPATIC FUNCTION IN PATIENTS WITH ADVANCED OVARIAN CANCER, Publisher: BMJ PUBLISHING GROUP, Pages: 681-681, ISSN: 1048-891X
Macintyre G, Goranova TE, De Silva D, et al., 2018, Copy-number signatures and mutational processes in ovarian carcinoma, Nature Genetics, Vol: 50, Pages: 1262-1270, ISSN: 1061-4036
The genomic complexity of profound copy-number aberration has prevented effective molecular stratification of ovarian cancers. To decode this complexity, we derived copy-number signatures from shallow whole genome sequencing of 117 high-grade serous ovarian cancer (HGSOC) cases, which were validated on 527 independent cases. We show that HGSOC comprises a continuum of genomes shaped by multiple mutational processes that result in known patterns of genomic aberration. Copy-number signature exposures at diagnosis predict both overall survival and the probability of platinum-resistant relapse. Measuring signature exposures provides a rational framework to choose combination treatments that target multiple mutational processes.
Antony J, Zanini E, Kelly Z, et al., 2018, The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer, EMBO Reports, Vol: 19, ISSN: 1469-221X
In ovarian cancer, the prometastatic RTK AXL promotes motility, invasion and poor prognosis. Here, we show that reduced survival caused by AXL overexpression can be mitigated by the expression of the GPI-anchored tumour suppressor OPCML Further, we demonstrate that AXL directly interacts with OPCML, preferentially so when AXL is activated by its ligand Gas6. As a consequence, AXL accumulates in cholesterol-rich lipid domains, where OPCML resides. Here, phospho-AXL is brought in proximity to the lipid domain-restricted phosphatase PTPRG, which de-phosphorylates the RTK/ligand complex. This prevents AXL-mediated transactivation of other RTKs (cMET and EGFR), thereby inhibiting sustained phospho-ERK signalling, induction of the EMT transcription factor Slug, cell migration and invasion. From a translational perspective, we show that OPCML enhances the effect of the phase II AXL inhibitor R428 in vitro and in vivo We therefore identify a novel mechanism by which two spatially restricted tumour suppressors, OPCML and PTPRG, coordinate to repress AXL-dependent oncogenic signalling.
Fotopoulou C, Sehouli J, Mahner S, et al., 2018, HIPEC: HOPE or HYPE in the fight against advanced ovarian cancer?, ANNALS OF ONCOLOGY, Vol: 29, Pages: 1610-1613, ISSN: 0923-7534
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- Citations: 32
Tzafetas M, Mitra A, Kalliala I, et al., 2018, Fertility-sparing surgery for presumed early-stage invasive cervical cancer: a survey of practice in the United Kingdom., Anticancer Research, Vol: 38, Pages: 3641-3646, ISSN: 0250-7005
AIM: To explore current practice in fertility-sparing surgery for cervical cancer in the UK. MATERIALS AND METHODS: A web-based structured questionnaire was designed and circulated to all members of the British Gynaecological Cancer Society. RESULTS: From 111 recipients, a total of 49 responses were collected. The majority of centres treated between 20-29 cases of invasive cervical cancer surgically (21/49, 42.9%) and performed between 0-5 cases of radical trachelectomy annually (29/49, 59.2%). The vaginal approach was the one most commonly used and was offered by almost half of the centres (21/49, 42.9%); laparoscopic techniques were offered in 13 (13/49, 26.6%). The responses were divided as to whether these cases should have been referred to supra-regional centres (25/49, 51.0%). CONCLUSION: With the use of Human Papillomavirus vaccination leading to a projected decrease in the number of cervical cancer incidence, patients may need to be referred to supraregional centres in the future.
Carter P, Alifrangis C, Cereser B, et al., 2018, Correction: Assessing tumor molecular profiling to guide treatments for patients with advanced female genital tract malignancy, Oncotarget, Vol: 9, Pages: 15164-15164, ISSN: 1949-2553
Correction to article DOI: https://dx.doi.org/10.18632/oncotarget.23675
Boutelle MG, Gowers SAN, Hamaoui K, et al., 2018, High temporal resolution delayed analysis of clinical microdialysate streams, Analyst, Vol: 143, Pages: 715-724, ISSN: 1364-5528
This paper presents the use of tubing to store clinical microdialysis samples for delayed analysis with high temporal resolution, offering an alternative to traditional discrete offline microdialysis sampling. Samples stored in this way were found to be stable for up to 72 days at −80 °C. Examples of how this methodology can be applied to glucose and lactate measurement in a wide range of in vivo monitoring experiments are presented. This paper presents a general model, which allows for an informed choice of tubing parameters for a given storage time and flow rate avoiding high back pressure, which would otherwise cause the microdialysis probe to leak, while maximising temporal resolution.
Seckl MJ, Fotopoulou C, 2018, Non-epithelial Ovarian Tumours and Gestational Trophoblastic Neoplasia, Gynaecological Oncology for the MRCOG, Pages: 153-164, ISBN: 9781316638712
Carter P, Alifrangis C, Cereser B, et al., 2017, Assessing tumor molecular profiling to guide treatments for patients with advanced female genital tract malignancy, Oncotarget, Vol: 9, Pages: 6007-6014, ISSN: 1949-2553
Tumor molecular profiling has enabled selection of targeted therapies in a host of solid tumors. Here we used a retrospective clinical cohort, to evaluate the benefit of tailoring treatments for female genital tract malignancy, using tumor molecular profiles. Clinical outcome data for 112 patients was retrospectively separated into two groups. These either followed a matched treatment plan that incorporated at least one drug recommended according to their tumor profile and none that were expected to have no benefit (64 patients), or was unmatched with suggested treatments and received at least one drug that was anticipated to lack benefit for that tumor (48 patients).In the group of patients whose drugs matched those recommended by molecular profiling of their tumor, their overall survival was 593 days on average, compared to 449 days for patients that did not; removing drugs predicted to have no benefit from treatment regimens received after profiling increased survival by 144 days on average (P = 0.0265). In the matched treatment group, 30% of patients had died by the last time of monitoring, whereas this was 40% in the unmatched group (P = 0.2778). The IHC biomarker for the progesterone receptor was demonstrated to be prognostic for survival.
Nasser S, Lathouras K, Campbell J, et al., 2017, IMPACT OF RIGHT UPPER QUADRANT CYTOREDUCTIVE TECHNIQUES FOR ADVANCED OVARIAN CANCER ON POSTOPERATIVE HEPATIC FUNCTION AND LIVER FAILURE, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 514-514, ISSN: 1048-891X
Nixon K, Cunnea P, Wulandari R, et al., 2017, DESCRIBING INTRA-TUMOURAL HETEROGENEITY IN HIGH GRADE SEROUS OVARIAN CANCER, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 516-516, ISSN: 1048-891X
Lu H, Fotopoulou C, Rockall A, et al., 2017, PRE-OPERATIVE RADIOMIC MODELS ANNOTATE EPITHELIAL OVARIAN CANCER PROGNOSTIC PHENOTYPES, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 502-502, ISSN: 1048-891X
Lu H, Fotopoulou C, Rockall A, et al., 2017, PRE-OPERATIVE RADIOMIC MODELS ANNOTATE EPITHELIAL OVARIAN CANCER PROGNOSTIC PHENOTYPES, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 1490-1490, ISSN: 1048-891X
Nixon K, Cunnea P, Wulandari R, et al., 2017, DESCRIBING INTRA-TUMOURAL HETEROGENEITY IN HIGH GRADE SEROUS OVARIAN CANCER, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 1613-1613, ISSN: 1048-891X
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