Imperial College London
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Prof. Christina Fotopoulou

Faculty of Medicine, Department of Surgery & Cancer

Chair in Gynaecological Cancer Surgery
 
 
 
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Contact

 

c.fotopoulou

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kyrgiou:2017:10.1002/14651858.CD009836.pub2,
author = {Kyrgiou, M and Kalliala, I and Mitra, A and fotopoulou, C and Ghaem-maghami, S and Martin-Hirsch, P and Cruickshank, M and Arbyn, M and Paraskevaidis, E},
doi = {10.1002/14651858.CD009836.pub2},
journal = {Cochrane Database of Systematic Reviews},
title = {Immediate referral to colposcopy versus cytological surveillance for minor cervical cytological abnormalities in the absence of HPV test},
url = {http://dx.doi.org/10.1002/14651858.CD009836.pub2},
volume = {1},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundA significant number of women are diagnosed with minor cytological abnormalities on cervical screening. Many authorities recommendsurveillance as spontaneous regression might occur. However,attendance for cytological follow-up decreases with time and might putsome women at risk of developing invasive disease.ObjectivesTo assess the optimum management strategy for women with minor cervical cytological abnormalities (atypical squamous cells ofundetermined significance - ASCUS or low-grade squamous intra-epithelial lesions - LSIL) at primary screening in the absence of HPV(human papillomavirus) DNA test.Search methodsWe searched the following electronic databases: Cochrane Central Register of Controlled Trials (CENTRAL Issue 4 2016), MEDLINE,and Embase from inception to 21 April 2016.Selection criteriaWe included randomised controlled trials (RCTs) comparing immediate colposcopy to cytological surveillance in women with atyp-ical squamous cells of undetermined significance (ASCUS/borderline) or low-grade squamous intra-epithelial lesions (LSIL/milddyskaryosis).Data collection and analysisThe primary outcome measure studied was the occurrence of cervicalintra-epithelial neoplasia (CIN). The secondary outcome measuresstudied included default rate, clinically significant anxiety and depression, and other self-reported adverse effects.We classified studies according to period of surveillance, at 6, 12, 24 or 36 months, as well as at 18 months, excluding a possibleexit-examination. We calculated pooled risk ratios (RR) and 95%confidence intervals (CI) using a random-effects model with inversevariance weighting. Inter-study heterogeneity was assessedwith I2statistics.Main resultsWe identified five RCTs with 11,466 participants that fulfilledthe inclusion criteria. There were 18 cases of invasive cervical cancer,seven in the immediate colposcopy and 11 in the cytological surveillance groups, respectively. Although immediate colposcopy detectsCIN2+ and CIN3+ earlier
AU  - Kyrgiou,M
AU  - Kalliala,I
AU  - Mitra,A
AU  - fotopoulou,C
AU  - Ghaem-maghami,S
AU  - Martin-Hirsch,P
AU  - Cruickshank,M
AU  - Arbyn,M
AU  - Paraskevaidis,E
DO  - 10.1002/14651858.CD009836.pub2
PY  - 2017///
SN  - 1469-493X
TI  - Immediate referral to colposcopy versus cytological surveillance for minor cervical cytological abnormalities in the absence of HPV test
T2  - Cochrane Database of Systematic Reviews
UR  - http://dx.doi.org/10.1002/14651858.CD009836.pub2
UR  - http://hdl.handle.net/10044/1/44054
VL  - 1
ER  -
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