Imperial College London
Alternate

ProfessorChristopheFraser

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.fraser Website

 
 
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Location

 

G28Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fryer:2022:10.1101/2022.12.02.518847,
author = {Fryer, HR and Golubchik, T and Hall, M and Fraser, C and Hinch, R and Ferretti, L and Thomson, L and Nurtay, A and Pellis, L and MackIntyre-Cockett, G and Trebes, A and Buck, D and Piazza, P and Green, A and Lonie, LJ and Smith, D and Bashton, M and Crown, M and Nelson, A and McCann, CM and Tariq, AM and Dos, Santos RN and Richards, Z and Bonsall, D and Lythgoe, KA},
doi = {10.1101/2022.12.02.518847},
title = {Viral burdens are associated with age and viral variant in a population-representative study of SARS-CoV-2 that accounts for time-since-infection related sampling bias},
url = {http://dx.doi.org/10.1101/2022.12.02.518847},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>In this study, we evaluated the impact of viral variant, in addition to other variables, on within-host viral burdens, by analysing cycle threshold (Ct) values derived from nose and throat swabs, collected as part of the UK COVID-19 Infection Survey. Because viral burden distributions determined from community survey data can be biased due to the impact of variant epidemiology on the time-since-infection of samples, we developed a method to explicitly adjust observed Ct value distributions to account for the expected bias. Analysing the adjusted Ct values using partial least squares regression, we found that among unvaccinated individuals with no known prior infection, the average Ct value was 0.94 lower among Alpha variant infections, compared those with the predecessor strain, B.1.177. However, among vaccinated individuals, it was 0.34 lower among Delta variant infections, compared to those with the Alpha variant. In addition, the average Ct value decreased by 0.20 for every 10 year age increment of the infected individual. In summary, within-host viral burdens are associated with age, in addition to the interplay of vaccination status and viral variant.</jats:p>
AU  - Fryer,HR
AU  - Golubchik,T
AU  - Hall,M
AU  - Fraser,C
AU  - Hinch,R
AU  - Ferretti,L
AU  - Thomson,L
AU  - Nurtay,A
AU  - Pellis,L
AU  - MackIntyre-Cockett,G
AU  - Trebes,A
AU  - Buck,D
AU  - Piazza,P
AU  - Green,A
AU  - Lonie,LJ
AU  - Smith,D
AU  - Bashton,M
AU  - Crown,M
AU  - Nelson,A
AU  - McCann,CM
AU  - Tariq,AM
AU  - Dos,Santos RN
AU  - Richards,Z
AU  - Bonsall,D
AU  - Lythgoe,KA
DO  - 10.1101/2022.12.02.518847
PY  - 2022///
TI  - Viral burdens are associated with age and viral variant in a population-representative study of SARS-CoV-2 that accounts for time-since-infection related sampling bias
UR  - http://dx.doi.org/10.1101/2022.12.02.518847
ER  -
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