Imperial College London
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Dr Chris Hadjichrysanthou

Faculty of Medicine, School of Public Health

Visiting Researcher
 
 
 
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Contact

 

c.hadjichrysanthou Website

 
 
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Location

 

LG36Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hadjichrysanthou:2016:10.1098/rsif.2016.0289,
author = {Hadjichrysanthou, C and Cauët, E and Lawrence, E and Vegvari, C and de, Wolf F and Anderson, RM},
doi = {10.1098/rsif.2016.0289},
journal = {Journal of the Royal Society Interface},
title = {Understanding the within-host dynamics of influenza A virus: from theory to clinical implications},
url = {http://dx.doi.org/10.1098/rsif.2016.0289},
volume = {13},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mathematical models have provided important insights into acute viral dynamics within individual patients. In this paper, we study the simplest target cell-limited models to investigate the within-host dynamics of influenza A virus infection in humans. Despite the biological simplicity of the models, we show how these can be used to understand the severity of the infection and the key attributes of possible immunotherapy and antiviral drugs for the treatment of infection at different times post infection. Through an analytic approach, we derive and estimate simple summary biological quantities that can provide novel insights into the infection dynamics and the definition of clinical endpoints. We focus on nine quantities, including the area under the viral load curve, peak viral load, the time to peak viral load and the level of cell death due to infection. Using Markov chain Monte Carlo methods, we fitted the models to data collected from 12 untreated volunteers who participated in two clinical studies that tested the antiviral drugs oseltamivir and zanamivir. Based on the results, we also discuss various difficulties in deriving precise estimates of the parameters, even in the very simple models considered, when experimental data are limited to viral load measures and/or there is a limited number of viral load measurements post infection.
AU  - Hadjichrysanthou,C
AU  - Cauët,E
AU  - Lawrence,E
AU  - Vegvari,C
AU  - de,Wolf F
AU  - Anderson,RM
DO  - 10.1098/rsif.2016.0289
PY  - 2016///
SN  - 1742-5689
TI  - Understanding the within-host dynamics of influenza A virus: from theory to clinical implications
T2  - Journal of the Royal Society Interface
UR  - http://dx.doi.org/10.1098/rsif.2016.0289
UR  - http://hdl.handle.net/10044/1/34606
VL  - 13
ER  -
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