Imperial College London
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Dr Chris Hadjichrysanthou

Faculty of Medicine, School of Public Health

Visiting Researcher
 
 
 
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Contact

 

c.hadjichrysanthou Website

 
 
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Location

 

LG36Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Evans:2018:10.1007/s10654-018-0381-0,
author = {Evans, S and McRae-McKee, K and Wong, MM and Hadjichrysanthou, C and De, Wolf F and Anderson, R},
doi = {10.1007/s10654-018-0381-0},
journal = {European Journal of Epidemiology},
pages = {635--644},
title = {The importance of endpoint selection: how effective does a drug need to be for success in a clinical trial of a possible Alzheimer's disease treatment?},
url = {http://dx.doi.org/10.1007/s10654-018-0381-0},
volume = {33},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - To date, Alzheimer's disease (AD) clinical trials have been largely unsuccessful. Failures have been attributed to a number of factors including ineffective drugs, inadequate targets, and poor trial design, of which the choice of endpoint is crucial. Using data from the Alzheimer's Disease Neuroimaging Initiative, we have calculated the minimum detectable effect size (MDES) in change from baseline of a range of measures over time, and in different diagnostic groups along the AD development trajectory. The Functional Activities Questionnaire score had the smallest MDES for a single endpoint where an effect of 27% could be detected within 3 years in participants with Late Mild Cognitive Impairment (LMCI) at baseline, closely followed by the Clinical Dementia Rating Sum of Boxes (CDRSB) score at 28% after 2 years in the same group. Composite measures were even more successful than single endpoints with an MDES of 21% in 3 years. Using alternative cognitive, imaging, functional, or composite endpoints, and recruiting patients that have LMCI could improve the success rate of AD clinical trials.
AU  - Evans,S
AU  - McRae-McKee,K
AU  - Wong,MM
AU  - Hadjichrysanthou,C
AU  - De,Wolf F
AU  - Anderson,R
DO  - 10.1007/s10654-018-0381-0
EP  - 644
PY  - 2018///
SN  - 0393-2990
SP  - 635
TI  - The importance of endpoint selection: how effective does a drug need to be for success in a clinical trial of a possible Alzheimer's disease treatment?
T2  - European Journal of Epidemiology
UR  - http://dx.doi.org/10.1007/s10654-018-0381-0
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29572656
UR  - http://hdl.handle.net/10044/1/59046
VL  - 33
ER  -
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