Imperial College London
Alternate

DrClaireHiggins

Faculty of Engineering, Department of Bioengineering

Reader in Tissue Regeneration
 
 
 
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Contact

 

c.higgins Website

 
 
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Location

 

Uren 319Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Boyle:2019:10.1126/sciadv.aay0244,
author = {Boyle, C and Plotczyk, M and Fayos, Villalta S and Patel, S and Hettiaratchy, S and Masouros, S and Masen, M and Higgins, C},
doi = {10.1126/sciadv.aay0244},
journal = {Science Advances},
pages = {1--13},
title = {Morphology and composition play distinct and complementary roles in the tolerance of plantar skin to mechanical load},
url = {http://dx.doi.org/10.1126/sciadv.aay0244},
volume = {5},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Plantar skin on the soles of the feet has a distinct morphology and composition that is thought to enhance its tolerance to mechanical loads, although the individual contributions of morphology and composition have never been quantified. Here, we combine multiscale mechanical testing and computational models of load bearing to quantify the mechanical environment of both plantar and nonplantar skin under load. We find that morphology and composition play distinct and complementary roles in plantar skin’s load tolerance. More specifically, the thick stratum corneum provides protection from stress-based injuries such as skin tears and blisters, while epidermal and dermal compositions provide protection from deformation-based injuries such as pressure ulcers. This work provides insights into the roles of skin morphology and composition more generally and will inform the design of engineered skin substitutes as well as the etiology of skin injury.
AU  - Boyle,C
AU  - Plotczyk,M
AU  - Fayos,Villalta S
AU  - Patel,S
AU  - Hettiaratchy,S
AU  - Masouros,S
AU  - Masen,M
AU  - Higgins,C
DO  - 10.1126/sciadv.aay0244
EP  - 13
PY  - 2019///
SN  - 2375-2548
SP  - 1
TI  - Morphology and composition play distinct and complementary roles in the tolerance of plantar skin to mechanical load
T2  - Science Advances
UR  - http://dx.doi.org/10.1126/sciadv.aay0244
UR  - https://advances.sciencemag.org/content/5/10/eaay0244
UR  - http://hdl.handle.net/10044/1/72315
VL  - 5
ER  -
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