Imperial College London
Alternate

DrClaireHiggins

Faculty of Engineering, Department of Bioengineering

Reader in Tissue Regeneration
 
 
 
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Contact

 

c.higgins Website

 
 
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Location

 

Uren 319Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Boyle:2021:10.1111/exd.14419,
author = {Boyle, CJ and Higgins, CA},
doi = {10.1111/exd.14419},
journal = {Experimental Dermatology},
pages = {1829--1833},
title = {Can plantar fibroblast implantation protect amputees from skin injury? A recipe for skin augmentation.},
url = {http://dx.doi.org/10.1111/exd.14419},
volume = {30},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Skin injuries remain a persistent problem for users of lower-limb prostheses despite sustained progress in prosthesis design. One factor limiting the prevention of skin injuries is that skin on the residual limb is not suited to bear the mechanical loads of ambulation. One part of the body that is suited to this task is the sole of the foot. Here, we propose a novel strategy to actively augment skin's tolerance to load, increasing its resistance to mechanically induced injuries. We hypothesise that the load tolerance of skin can be augmented by autologous transplantation of plantar fibroblasts into the residual limb dermis. We expect that introducing plantar fibroblasts will induce the overlying keratinocytes to express plantar-specific keratins leading to a tougher epidermis. Using a computational finite element model of a weight-bearing residual limb, we estimate that skin deformation (a key driver of pressure ulcer injuries) could be halved by reprogramming skin to a plantar-like phenotype. We believe this strategy could yield new progress in pressure ulcer prevention for amputees, facilitating rehabilitation and improving quality of life for patients.
AU  - Boyle,CJ
AU  - Higgins,CA
DO  - 10.1111/exd.14419
EP  - 1833
PY  - 2021///
SN  - 0906-6705
SP  - 1829
TI  - Can plantar fibroblast implantation protect amputees from skin injury? A recipe for skin augmentation.
T2  - Experimental Dermatology
UR  - http://dx.doi.org/10.1111/exd.14419
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34173264
UR  - https://onlinelibrary.wiley.com/doi/10.1111/exd.14419
UR  - http://hdl.handle.net/10044/1/89965
VL  - 30
ER  -
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