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@article{Eungdamrong:2014:10.1177/1535370214538747,
author = {Eungdamrong, NJ and Higgins, C and Guo, Z and Lee, WH and Gillette, B and Sia, S and Christiano, AM},
doi = {10.1177/1535370214538747},
journal = {Exp Biol Med (Maywood)},
title = {Challenges and promises in modeling dermatologic disorders with bioengineered skin},
url = {http://dx.doi.org/10.1177/1535370214538747},
year = {2014}
}

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TY  - JOUR
AB  - The tremendous cost of drug development is often attributed to the long time interval between identifying lead compounds in preclinical studies to assessing clinical efficacy in randomized clinical trials. Many candidate molecules show promise in cell culture or animal models, only to fail in late stage in human investigations. There is a need for novel technologies that allow investigators to quickly and reliably predict drug safety and efficacy. The advent of microtechnology has made it possible to integrate multiple microphysiologic organ systems into a single microfabricated chip. This review focuses on three-dimensional engineered skin, which has enjoyed a long history of uses both in clinical treatments of refractory ulcers and as a laboratory model. We discuss current biological and engineering challenges in construction of a robust bioengineered skin and provide a blueprint for its potential utility to model dermatologic disorders such as psoriasis or cutaneous drug reactions.
AU  - Eungdamrong,NJ
AU  - Higgins,C
AU  - Guo,Z
AU  - Lee,WH
AU  - Gillette,B
AU  - Sia,S
AU  - Christiano,AM
DO  - 10.1177/1535370214538747
PY  - 2014///
TI  - Challenges and promises in modeling dermatologic disorders with bioengineered skin
T2  - Exp Biol Med (Maywood)
UR  - http://dx.doi.org/10.1177/1535370214538747
UR  - http://www.ncbi.nlm.nih.gov/pubmed/24951469
UR  - http://ebm.sagepub.com/content/early/2014/06/18/1535370214538747
ER  -

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