Imperial College London
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DrCliveHoggart

Faculty of Medicine, Department of Infectious Disease

Honorary Research Officer
 
 
 
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Contact

 

+44 (0)20 7594 3915c.hoggart

 
 
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Location

 

231Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hoggart:2014:10.1371/journal.pgen.1004508,
author = {Hoggart, CJ and Venturini, G and Mangino, M and Gomez, F and Ascari, G and Zhao, JH and Teumer, A and Winkler, TW and Tsernikova, N and Luan, J and Mihailov, E and Ehret, GB and Zhang, W and Lamparter, D and Esko, T and Mace, A and Rueeger, S and Bochud, P-Y and Barcella, M and Dauvilliers, Y and Benyamin, B and Evans, DM and Hayward, C and Lopez, MF and Franke, L and Russo, A and Heid, IM and Salvi, E and Vendantam, S and Arking, DE and Boerwinkle, E and Chambers, JC and Fiorito, G and Grallert, H and Guarrera, S and Homuth, G and Huffman, JE and Porteous, D and Moradpour, D and Iranzo, A and Hebebrand, J and Kemp, JP and Lammers, GJ and Aubert, V and Heim, MH and Martin, NG and Montgomery, GW and Peraita-Adrados, R and Santamaria, J and Negro, F and Schmidt, CO and Scott, RA and Spector, TD and Strauch, K and Voelzke, H and Wareham, NJ and Yuan, W and Bell, JT and Chakravarti, A and Kooner, JS and Peters, A and Matullo, G and Wallaschofski, H and Whitfield, JB and Paccaud, F and Voll},
doi = {10.1371/journal.pgen.1004508},
journal = {PLOS Genetics},
title = {Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index},
url = {http://dx.doi.org/10.1371/journal.pgen.1004508},
volume = {10},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present anovel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. Themethod exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups.We applied the method to .56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six leadSNPs were carried forward for replication in five family-based studies (of ,4,000 trios). Two SNPs replicated: the paternalrs2471083-C allele (located near the imprinted KCNK9 gene) and the paternal rs3091869-T allele (located near the SLC2A10gene) increased BMI equally (beta = 0.11 (SD), P,0.0027) compared to the respective maternal alleles. Real-time PCRexperiments of lymphoblastoid cell lines from the CEPH families showed that expression of both genes was dependent onparental origin of the SNPs alleles (P,0.01). Our scheme opens new opportunities to exploit GWAS data of unrelatedindividuals to identify POEs and demonstrates that they play an important role in adult obesity.
AU  - Hoggart,CJ
AU  - Venturini,G
AU  - Mangino,M
AU  - Gomez,F
AU  - Ascari,G
AU  - Zhao,JH
AU  - Teumer,A
AU  - Winkler,TW
AU  - Tsernikova,N
AU  - Luan,J
AU  - Mihailov,E
AU  - Ehret,GB
AU  - Zhang,W
AU  - Lamparter,D
AU  - Esko,T
AU  - Mace,A
AU  - Rueeger,S
AU  - Bochud,P-Y
AU  - Barcella,M
AU  - Dauvilliers,Y
AU  - Benyamin,B
AU  - Evans,DM
AU  - Hayward,C
AU  - Lopez,MF
AU  - Franke,L
AU  - Russo,A
AU  - Heid,IM
AU  - Salvi,E
AU  - Vendantam,S
AU  - Arking,DE
AU  - Boerwinkle,E
AU  - Chambers,JC
AU  - Fiorito,G
AU  - Grallert,H
AU  - Guarrera,S
AU  - Homuth,G
AU  - Huffman,JE
AU  - Porteous,D
AU  - Moradpour,D
AU  - Iranzo,A
AU  - Hebebrand,J
AU  - Kemp,JP
AU  - Lammers,GJ
AU  - Aubert,V
AU  - Heim,MH
AU  - Martin,NG
AU  - Montgomery,GW
AU  - Peraita-Adrados,R
AU  - Santamaria,J
AU  - Negro,F
AU  - Schmidt,CO
AU  - Scott,RA
AU  - Spector,TD
AU  - Strauch,K
AU  - Voelzke,H
AU  - Wareham,NJ
AU  - Yuan,W
AU  - Bell,JT
AU  - Chakravarti,A
AU  - Kooner,JS
AU  - Peters,A
AU  - Matullo,G
AU  - Wallaschofski,H
AU  - Whitfield,JB
AU  - Paccaud,F
AU  - Vollenweider,P
AU  - Bergmann,S
AU  - Beckmann,JS
AU  - Tafti,M
AU  - Hastie,ND
AU  - Cusi,D
AU  - Bochud,M
AU  - Frayling,TM
AU  - Metspalu,A
AU  - Jarvelin,M-R
AU  - Scherag,A
AU  - Smith,GD
AU  - Borecki,IB
AU  - Rousson,V
AU  - Hirschhorn,JN
AU  - Rivolta,C
AU  - Loos,RJF
AU  - Kutalik,Z
DO  - 10.1371/journal.pgen.1004508
PY  - 2014///
SN  - 1553-7390
TI  - Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index
T2  - PLOS Genetics
UR  - http://dx.doi.org/10.1371/journal.pgen.1004508
UR  - http://hdl.handle.net/10044/1/28741
VL  - 10
ER  -
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