Publications
75 results found
Jayasena CN, Abbara A, Izzi-Engbeaya C, et al., 2014, Reduced Levels of Plasma Kisspeptin During the Antenatal Booking Visit Are Associated With Increased Risk of Miscarriage, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 99, Pages: E2652-E2660, ISSN: 0021-972X
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- Citations: 48
Jayasena CN, Abbara A, Comninos AN, et al., 2014, Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization, Journal of Clinical Investigation, Vol: 124, Pages: 3667-3677, ISSN: 0021-9738
BACKGROUND. Patients with mutations that inactivate kisspeptin signaling are infertile. Kisspeptin-54, the major circulating isoform of kisspeptin in humans, potently stimulates reproductive hormone secretion in humans. Animal studies suggest that kisspeptin is involved in generation of the luteinizing hormone surge, which is required for ovulation; therefore, we hypothesized that kisspeptin-54 could be used to trigger egg maturation in women undergoing in vitro fertilization therapy.METHODS. Following superovulation with recombinant follicle-stimulating hormone and administration of gonadotropin-releasing hormone antagonist to prevent premature ovulation, 53 women were administered a single subcutaneous injection of kisspeptin-54 (1.6 nmol/kg, n = 2; 3.2 nmol/kg, n = 3; 6.4 nmol/kg, n = 24; 12.8 nmol/kg, n = 24) to induce a luteinizing hormone surge and egg maturation. Eggs were retrieved transvaginally 36 hours after kisspeptin injection, assessed for maturation (primary outcome), and fertilized by intracytoplasmic sperm injection with subsequent transfer of one or two embryos.RESULTS. Egg maturation was observed in response to each tested dose of kisspeptin-54, and the mean number of mature eggs per patient generally increased in a dose-dependent manner. Fertilization of eggs and transfer of embryos to the uterus occurred in 92% (49/53) of kisspeptin-54–treated patients. Biochemical and clinical pregnancy rates were 40% (21/53) and 23% (12/53), respectively.CONCLUSION. This study demonstrates that a single injection of kisspeptin-54 can induce egg maturation in women with subfertility undergoing in vitro fertilization therapy. Subsequent fertilization of eggs matured following kisspeptin-54 administration and transfer of resulting embryos can lead to successful human pregnancy.TRIAL REGISTRATION. ClinicalTrials.gov NCT01667406.FUNDING. Medical Research Council, Wellcome Trust, and National Institute for Health Research.
Dhillo WS, Izzi-Engbeaya C, 2014, Kisspeptin, a novel regulator of pituitary gonadotrophins, Recent Advances in Obstetrics & Gynaecology: 25, Editors: Ledger, Clark, Publisher: JP Medical Ltd, Pages: 139-150, ISBN: 9781907816802
Comninos AN, Jayasena CN, Stefanopoulou E, et al., 2014, The hypothalamic hormone neurokinin B: a novel therapeutic target for menopausal hot flushes, 30th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 105-105, ISSN: 0268-1161
Abbara A, Jayasena CN, Comninos AN, et al., 2014, Kisspeptin - a novel physiological trigger for oocyte maturation in IVF treatment, 30th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 50-50, ISSN: 0268-1161
Comninos AN, Jayasena CN, Stefanopoulou E, et al., 2014, Neurokinin B Administration Induces Menopausal-like Hot Flushes in Healthy Young Women, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Abbara A, Jayasena CN, Comninos AN, et al., 2014, Kisspeptin - a Novel Physiological Trigger for Oocyte Maturation in IVF Treatment, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Abbara A, Jayasena CN, Izzi-Engbeaya C, et al., 2014, Plasma Kisspeptin Measurement during Early Pregnancy Is a Highly Predictive Marker of Subsequent Miscarriage, Publisher: ENDOCRINE SOC, ISSN: 0163-769X
Comninos A, Jayasena C, Nijher G, et al., 2014, The effects of kisspeptin administration on the menstrual cycle in healthy women, LANCET, Vol: 383, Pages: 37-37, ISSN: 0140-6736
Abbara A, Jayasena C, Comninos A, et al., 2014, Kisspeptin: a novel physiological trigger for oocyte maturation in in-vitro fertilisation treatment, LANCET, Vol: 383, Pages: 17-17, ISSN: 0140-6736
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- Citations: 7
Izzi-Engbeaya C, Meeran K, Dhillo WS, 2013, Kisspeptin is providing new insights into the control of reproduction, CLINICAL MEDICINE, Vol: 13, Pages: 547-548, ISSN: 1470-2118
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- Citations: 1
Jayasena CN, Comninos AN, Nijher GMK, et al., 2013, Twice-Daily Subcutaneous Injection of Kisspeptin-54 Does Not Abolish Menstrual Cyclicity in Healthy Female Volunteers, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 98, Pages: 4464-4474, ISSN: 0021-972X
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- Citations: 22
Izzi-Engbeaya C, Zac-Varghese S, Palazzo F, et al., 2013, A young fit man presenting to the emergency department with a painful neck due to a thyroid abscess, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 106, Pages: 1041-1042, ISSN: 1460-2725
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- Citations: 2
Jayasena CN, Comninos AN, Veldhuis JD, et al., 2013, A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women, CLINICAL ENDOCRINOLOGY, Vol: 79, Pages: 558-563, ISSN: 0300-0664
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- Citations: 37
Comninos AN, Jayasena CN, Nijher GMK, et al., 2013, Chronic kisspeptin administration advances the menstrual cycle in healthy women, 29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 334-335, ISSN: 0268-1161
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