Imperial College London
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DrChiomaIzzi-Engbeaya

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

IPPRF Research Fellow
 
 
 
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Contact

 

+44 (0)20 3313 3242c.izzi

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mills:2020:10.1038/s41574-020-00438-1,
author = {Mills, EG and Izzi-Engbeaya, C and Abbara, A and Comninos, AN and Dhillo, WS},
doi = {10.1038/s41574-020-00438-1},
journal = {Nature Reviews Endocrinology},
pages = {97--113},
title = {Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour},
url = {http://dx.doi.org/10.1038/s41574-020-00438-1},
volume = {17},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin and their pathophysiological roles are increasingly the subject of investigation. Evidence suggests that these bioactive peptides play a role in the regulation of metabolism, pancreatic β-cell function, energy homeostasis, mood and behaviour in several species, including zebrafish, rodents and humans. Galanin signalling suppresses insulin secretion in animal models (but not in humans), is potently obesogenic and plays putative roles governing certain evolutionary behaviours and mood modulation. Spexin decreases insulin secretion and has potent anorectic, analgesic, anxiolytic and antidepressive-like effects in animal models. Kisspeptin modulates glucose-stimulated insulin secretion, food intake and/or energy expenditure in animal models and humans. Furthermore, kisspeptin is implicated in the control of reproductive behaviour in animals, modulation of human sexual and emotional brain processing, and has antidepressive and fear-suppressing effects. In addition, galanin-like peptide is a further member of the galaninergic family that plays emerging key roles in metabolism and behaviour. Therapeutic interventions targeting galanin, spexin and/or kisspeptin signalling pathways could therefore contribute to the treatment of conditions ranging from obesity to mood disorders. However, many gaps and controversies exist, which must be addressed before the therapeutic potential of these bioactive peptides can be established.
AU  - Mills,EG
AU  - Izzi-Engbeaya,C
AU  - Abbara,A
AU  - Comninos,AN
AU  - Dhillo,WS
DO  - 10.1038/s41574-020-00438-1
EP  - 113
PY  - 2020///
SN  - 1759-5029
SP  - 97
TI  - Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour
T2  - Nature Reviews Endocrinology
UR  - http://dx.doi.org/10.1038/s41574-020-00438-1
UR  - https://www.nature.com/articles/s41574-020-00438-1
UR  - http://hdl.handle.net/10044/1/84773
VL  - 17
ER  -
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