Imperial College London
Alternate

Dr. Channa Jayasena MA PhD MRCP FRCPath

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Reader in Reproductive Endocrinology
 
 
 
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Contact

 

c.jayasena Website

 
 
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Location

 

6N5CCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Agarwal:2019:10.5534/wjmh.190055,
author = {Agarwal, A and Parekh, N and Panner, Selvam MK and Henkel, R and Shah, R and Homa, ST and Ramasamy, R and Ko, E and Tremellen, K and Esteves, S and Majzoub, A and Alvarez, JG and Gardner, DK and Jayasena, CN and Ramsay, JW and Cho, CL and Saleh, R and Sakkas, D and Hotaling, JM and Lundy, SD and Vij, S and Marmar, J and Gosalvez, J and Sabanegh, E and Park, HJ and Zini, A and Kavoussi, P and Micic, S and Smith, R and Busetto, GM and Bakrcolu, ME and Haidl, G and Balercia, G and Puchalt, NG and Ben-Khalifa, M and Tadros, N and Kirkman-Browne, J and Moskovtsev, S and Huang, X and Borges, E and Franken, D and Bar-Chama, N and Morimoto, Y and Tomita, K and Srini, VS and Ombelet, W and Baldi, E and Muratori, M and Yumura, Y and La, Vignera S and Kosgi, R and Martinez, MP and Evenson, DP and Zylbersztejn, DS and Roque, M and Cocuzza, M and Vieira, M and Ben-Meir, A and Orvieto, R and Levitas, E and Wiser, A and Arafa, M and Malhotra, V and Parekattil, SJ and Elbardisi, H and Carvalho, L and },
doi = {10.5534/wjmh.190055},
journal = {World Journal of Mens Health},
title = {Male oxidative stress infertility (MOSI): proposed terminology and clinical practice guidelines for management of idiopathic male infertility},
url = {http://dx.doi.org/10.5534/wjmh.190055},
volume = {37},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause.
AU  - Agarwal,A
AU  - Parekh,N
AU  - Panner,Selvam MK
AU  - Henkel,R
AU  - Shah,R
AU  - Homa,ST
AU  - Ramasamy,R
AU  - Ko,E
AU  - Tremellen,K
AU  - Esteves,S
AU  - Majzoub,A
AU  - Alvarez,JG
AU  - Gardner,DK
AU  - Jayasena,CN
AU  - Ramsay,JW
AU  - Cho,CL
AU  - Saleh,R
AU  - Sakkas,D
AU  - Hotaling,JM
AU  - Lundy,SD
AU  - Vij,S
AU  - Marmar,J
AU  - Gosalvez,J
AU  - Sabanegh,E
AU  - Park,HJ
AU  - Zini,A
AU  - Kavoussi,P
AU  - Micic,S
AU  - Smith,R
AU  - Busetto,GM
AU  - Bakrcolu,ME
AU  - Haidl,G
AU  - Balercia,G
AU  - Puchalt,NG
AU  - Ben-Khalifa,M
AU  - Tadros,N
AU  - Kirkman-Browne,J
AU  - Moskovtsev,S
AU  - Huang,X
AU  - Borges,E
AU  - Franken,D
AU  - Bar-Chama,N
AU  - Morimoto,Y
AU  - Tomita,K
AU  - Srini,VS
AU  - Ombelet,W
AU  - Baldi,E
AU  - Muratori,M
AU  - Yumura,Y
AU  - La,Vignera S
AU  - Kosgi,R
AU  - Martinez,MP
AU  - Evenson,DP
AU  - Zylbersztejn,DS
AU  - Roque,M
AU  - Cocuzza,M
AU  - Vieira,M
AU  - Ben-Meir,A
AU  - Orvieto,R
AU  - Levitas,E
AU  - Wiser,A
AU  - Arafa,M
AU  - Malhotra,V
AU  - Parekattil,SJ
AU  - Elbardisi,H
AU  - Carvalho,L
AU  - Dada,R
AU  - Sifer,C
AU  - Talwar,P
AU  - Gudeloglu,A
AU  - Mahmoud,AMA
AU  - Terras,K
AU  - Yazbeck,C
AU  - Nebojsa,B
AU  - Durairajanayagam,D
AU  - Mounir,A
AU  - Kahn,LG
AU  - Baskaran,S
AU  - Pai,RD
AU  - Paoli,D
AU  - Leisegang,K
AU  - Moein,MR
AU  - Malik,S
AU  - Yaman,O
AU  - Samanta,L
AU  - Bayane,F
AU  - Jindal,SK
AU  - Kendirci,M
AU  - Altay,B
AU  - Perovic,D
AU  - Harlev,A
DO  - 10.5534/wjmh.190055
PY  - 2019///
SN  - 2287-4208
TI  - Male oxidative stress infertility (MOSI): proposed terminology and clinical practice guidelines for management of idiopathic male infertility
T2  - World Journal of Mens Health
UR  - http://dx.doi.org/10.5534/wjmh.190055
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31081299
UR  - http://hdl.handle.net/10044/1/71413
VL  - 37
ER  -
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