Imperial College London
Alternate

Dr. Channa Jayasena MA PhD MRCP FRCPath

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Reader in Reproductive Endocrinology
 
 
 
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Contact

 

c.jayasena Website

 
 
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Location

 

6N5CCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jayasena:2021:10.3390/diagnostics11091550,
author = {Jayasena, CN and Sironen, A},
doi = {10.3390/diagnostics11091550},
journal = {Diagnostics},
pages = {1--15},
title = {Diagnostics and management of male infertility in primary ciliary dyskinesia},
url = {http://dx.doi.org/10.3390/diagnostics11091550},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Primary ciliary dyskinesia (PCD), a disease caused by the malfunction of motile cilia, manifests mainly with chronic recurrent respiratory infections. In men, PCD is also often associated with infertility due to immotile sperm. Since causative mutations for PCD were identified in over 50 genes, the role of these genes in sperm development should be investigated in order to understand the effect of PCD mutations on male fertility. Previous studies showed that different dynein arm heavy chains are present in respiratory cilia and sperm flagellum, which may partially explain the variable effects of mutations on airways and fertility. Furthermore, recent studies showed that male reproductive tract motile cilia may play an important part in sperm maturation and transport. In some PCD patients, extremely low sperm counts were reported, which may be due to motile cilia dysfunction in the reproductive tract rather than problems with sperm development. However, the exact roles of PCD genes in male fertility require additional studies, as do the treatment options. In this review, we discuss the diagnostic and treatment options for men with PCD based on the current knowledge.
AU  - Jayasena,CN
AU  - Sironen,A
DO  - 10.3390/diagnostics11091550
EP  - 15
PY  - 2021///
SN  - 2075-4418
SP  - 1
TI  - Diagnostics and management of male infertility in primary ciliary dyskinesia
T2  - Diagnostics
UR  - http://dx.doi.org/10.3390/diagnostics11091550
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000699255900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/2075-4418/11/9/1550
UR  - http://hdl.handle.net/10044/1/98361
VL  - 11
ER  -
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