Imperial College London
Alternate

Dr. Channa Jayasena MA PhD MRCP FRCPath

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Reader in Reproductive Endocrinology
 
 
 
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Contact

 

c.jayasena Website

 
 
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Location

 

6N5CCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kaur:2021:10.1016/j.metabol.2021.154908,
author = {Kaur, V and Dimitriadis, G and Perez-Pevida, B and Bansi, D and Jayasena, C and Bate, D and Houghton, R and Fielding, B and Balfoussia, D and Webber, L and Miao, Y and Mears, F and Jackson, N and Coppin, L and Pereze, J and williams, M and Johnson, B and Umpleby, M and Randeva, H and Miras, A},
doi = {10.1016/j.metabol.2021.154908},
journal = {Metabolism: clinical and experimental},
pages = {1--8},
title = {Mechanisms of action of duodenal mucosal resurfacing in insulin resistant women with polycystic ovary syndrome},
url = {http://dx.doi.org/10.1016/j.metabol.2021.154908},
volume = {125},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundDuodenal mucosal resurfacing (DMR) is a novel day-case endoscopic intervention which results in weight loss-independent reductions in HbA1c in patient with type 2 diabetes mellitus (T2DM). We hypothesized that DMR works by increasing insulin sensitivity and we aimed to investigate the mechanism of action of DMR through longitudinal metabolic phenotyping in humans.MethodsThirty-two insulin-resistant women with polycystic ovary syndrome (PCOS) and obesity were randomised in a double-blinded manner to DMR or sham endoscopy. They underwent measurements of insulin sensitivity using euglycaemic hyperinsulinaemic clamps, insulin secretion using oral glucose tolerance tests and reproductive function using weekly reproductive hormone profiles and ovarian ultrasonography for 6months post-intervention.ResultsA small increase in total body insulin sensitivity measured by the clamp was observed in both groups at week 12. An increase in insulin sensitivity, as measured by HOMA-IR, was observed in both groups at week 24. There was an increase in the number of menses (median 2 DMR, 0.5 sham). There were no significant differences between the two groups in these outcomes or insulin secretion.ConclusionsThese findings suggest that DMR does not work by increasing insulin sensitivity in euglycaemic, insulin resistant women with PCOS. The procedure may exert its effects only in the context of hyperglycaemia or pathologically hyperplastic, insulin-desensitised duodenal mucosa.
AU  - Kaur,V
AU  - Dimitriadis,G
AU  - Perez-Pevida,B
AU  - Bansi,D
AU  - Jayasena,C
AU  - Bate,D
AU  - Houghton,R
AU  - Fielding,B
AU  - Balfoussia,D
AU  - Webber,L
AU  - Miao,Y
AU  - Mears,F
AU  - Jackson,N
AU  - Coppin,L
AU  - Pereze,J
AU  - williams,M
AU  - Johnson,B
AU  - Umpleby,M
AU  - Randeva,H
AU  - Miras,A
DO  - 10.1016/j.metabol.2021.154908
EP  - 8
PY  - 2021///
SN  - 0026-0495
SP  - 1
TI  - Mechanisms of action of duodenal mucosal resurfacing in insulin resistant women with polycystic ovary syndrome
T2  - Metabolism: clinical and experimental
UR  - http://dx.doi.org/10.1016/j.metabol.2021.154908
UR  - https://www.sciencedirect.com/science/article/pii/S0026049521002080?via%3Dihub
UR  - http://hdl.handle.net/10044/1/92602
VL  - 125
ER  -
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