Imperial College London
Alternate

Dr. Channa Jayasena MA PhD MRCP FRCPath

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Reader in Reproductive Endocrinology
 
 
 
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Contact

 

c.jayasena Website

 
 
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Location

 

6N5CCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sharma:2022:10.1111/cen.14856,
author = {Sharma, A and Davies, R and Kapoor, A and Islam, H and Webber, L and Jayasena, CNN},
doi = {10.1111/cen.14856},
journal = {Clinical Endocrinology},
pages = {285--295},
title = {The effect of hormone replacement therapy on cognition and mood},
url = {http://dx.doi.org/10.1111/cen.14856},
volume = {98},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivesTo summarise the available data regarding the effect of hormone replacement therapy (HRT) on cognition and mood in women.BackgroundComplaints of impaired cognition and mood are common in the peri-menopausal and menopausal period. There is debate as to whether HRT can ameliorate this phenomenon.DesignA literature search of studies using electronic databases was conducted. Both randomised control trials and observational studies were included.PatientsPerimenopausal and menopausal women.ResultsDue to the heterogenicity of results it is challenging to draw firm conclusions. The preparations used in many of the studies are older regimes no longer routinely used clinically. The notion of a ‘critical window’ for HRT is compelling, suggesting HRT has a positive impact on cognition when administered in the peri-menopausal or early postmenopausal period but may have negative effects on cognition in the older, postmenopausal woman. The evidence would seem to suggest importance of hormonal replacement in woman undergoing a surgical menopause, especially when young. It remains unclear for how long they ought to continue HRT though until at least the natural age of the menopause seems reasonable. Evidence for a positive effect of HRT on mood is more convincing, though possibly more efficacious in the younger age group. The effect of HRT on anxiety is less clear.ConclusionsFurther study, particularly focusing on the more contemporaneous HRT preparations, is warranted before evidence-based conclusions can be drawn.
AU  - Sharma,A
AU  - Davies,R
AU  - Kapoor,A
AU  - Islam,H
AU  - Webber,L
AU  - Jayasena,CNN
DO  - 10.1111/cen.14856
EP  - 295
PY  - 2022///
SN  - 0300-0664
SP  - 285
TI  - The effect of hormone replacement therapy on cognition and mood
T2  - Clinical Endocrinology
UR  - http://dx.doi.org/10.1111/cen.14856
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000897854900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://onlinelibrary.wiley.com/doi/10.1111/cen.14856
UR  - http://hdl.handle.net/10044/1/103921
VL  - 98
ER  -
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