Imperial College London
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ProfessorCeciliaJohansson

Faculty of Medicine, National Heart & Lung Institute

Professor of Mucosal Immunology
 
 
 
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Contact

 

+44 (0)20 7594 2531c.johansson

 
 
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Location

 

367Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Makris:2017:10.3389/fimmu.2017.00259,
author = {Makris, S and Paulsen, M and Johansson, C},
doi = {10.3389/fimmu.2017.00259},
journal = {Frontiers in Immunology},
title = {Type I interferons as regulators of lung inflammation},
url = {http://dx.doi.org/10.3389/fimmu.2017.00259},
volume = {8},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Immune  responses  to  lung  infections  must  be  tightly  regulated  in  order  to  permit pathogen  eradication  while  maintaining organ  function. Exuberant  or  dysregulated inflammation can impair gas exchange and underlies many instances of lung disease. An  important  driver  of  inflammation  in  the  lung  is  the  interferon (IFN) response. Type I IFNs are anti-viral cytokines that induce a large range of proteins that impair viral replication in  infected  cells.  This  cell-intrinsic  action  plays  a  crucial  role  in protecting the  lungs from  spread of  respiratory  viruses. However, type  I  IFNs have also recently been found to be central to the initiation of lung inflammatory responses, by inducing recruitment  and  activation  of  immune  cells. This helps control  virus burden but can cause detrimental immunopathology and contribute to disease severity.  Furthermore,  there  is  now  increasing  evidence  that  type  I  IFNs  are  not  only  induced after  viral  infections  but  also after  infection  with  bacteria  and fungi. The  pro-inflammatory function of type I IFNs in the lung opens up the possibility of immune modulation  directed  against  this  anti-viral  cytokine  family. In  this  review, the initiation and  signaling of type I IFNs as well as their role in driving and maintaining lung inflammation will be discussed.
AU  - Makris,S
AU  - Paulsen,M
AU  - Johansson,C
DO  - 10.3389/fimmu.2017.00259
PY  - 2017///
SN  - 1664-3224
TI  - Type I interferons as regulators of lung inflammation
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2017.00259
UR  - http://hdl.handle.net/10044/1/44888
VL  - 8
ER  -
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