Imperial College London
Portrait Picture

Mr Christos Kontovounisios

Faculty of Medicine, Department of Surgery & Cancer

Visiting Reader
 
 
 
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Contact

 

+44 (0)20 3315 8529c.kontovounisios

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kontovounisios:2021:10.3390/nu13051451,
author = {Kontovounisios, C},
doi = {10.3390/nu13051451},
journal = {Nutrients},
pages = {1--12},
title = {The effect of perioperative administration of probiotics on col- 2 colorectal cancer surgery outcomes},
url = {http://dx.doi.org/10.3390/nu13051451},
volume = {13},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The perioperative care of colorectal cancer (CRC) patients includes antibiotics. Although antibiotics do provide a certain protection against infections, they do not eliminate them completely, and they do carry risks of microbial resistance and disruption of the microbiome. Probiotics can maintain the microbiome’s balance postoperatively by maintaining intestinal mucosal integrity and reducing bacterial translocation (BT). This review aims to assess the role of probiotics in the perioperative management of CRC patients. The outcomes were categorised into: postoperative infectious and non-infectious complications, BT rate analysis, and intestinal permeability assessment. Fifteen randomised controlled trials (RCTs) were included. There was a trend towards lower rates of postoperative infectious and non-infectious complications with probiotics versus placebo. Probiotics reduced BT, maintained intestinal mucosal permeability, and provided a better balance of beneficial to pathogenic microorganisms. Heterogeneity among RCTs was high. Factors that influence the effect of probiotics include the species used, using a combination vs. single species, the duration of administration, and the location of the bowel resection. Although this review provided evidence for how probiotics possibly operate and reported notable evidence that probiotics can lower rates of infections, heterogeneity was observed. In order to corroborate the findings, future RCTs should keep the aforementioned factors constant.
AU  - Kontovounisios,C
DO  - 10.3390/nu13051451
EP  - 12
PY  - 2021///
SN  - 2072-6643
SP  - 1
TI  - The effect of perioperative administration of probiotics on col- 2 colorectal cancer surgery outcomes
T2  - Nutrients
UR  - http://dx.doi.org/10.3390/nu13051451
UR  - https://www.mdpi.com/2072-6643/13/5/1451
UR  - http://hdl.handle.net/10044/1/89401
VL  - 13
ER  -
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