Imperial College London
Portrait Picture

DrChiu FanLee

Faculty of Engineering, Department of Bioengineering

Reader in Theoretical Biophysics
 
 
 
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Contact

 

+44 (0)20 7594 6493c.lee Website

 
 
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Location

 

3.17Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Partridge:2022:10.1371/journal.pone.0272587,
author = {Partridge, B and Gonzalez, Anton S and Khorshed, R and Adams, G and Pospori, C and Lo, Celso C and Lee, CF},
doi = {10.1371/journal.pone.0272587},
journal = {PLoS One},
pages = {1--26},
title = {Heterogeneous run-and-tumble motion accounts for transient non-Gaussian super-diffusion in haematopoietic multi-potent progenitor cells},
url = {http://dx.doi.org/10.1371/journal.pone.0272587},
volume = {17},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Multi-potent progenitor (MPP) cells act as a key intermediary step between haematopoietic stem cells and the entirety of the mature blood cell system. Their eventual fate determination is thought to be achieved through migration in and out of spatially distinct niches. Here we first analyze statistically MPP cell trajectory data obtained from a series of long time-course 3D in vivo imaging experiments on irradiated mouse calvaria, and report that MPPs display transient super-diffusion with apparent non-Gaussian displacement distributions. Second, we explain these experimental findings using a run-and-tumble model of cell motion which incorporates the observed dynamical heterogeneity of the MPPs. Third, we use our model to extrapolate the dynamics to time-periods currently inaccessible experimentally, which enables us to quantitatively estimate the time and length scales at which super-diffusion transitions to Fickian diffusion. Our work sheds light on the potential importance of motility in early haematopoietic progenitor function.
AU  - Partridge,B
AU  - Gonzalez,Anton S
AU  - Khorshed,R
AU  - Adams,G
AU  - Pospori,C
AU  - Lo,Celso C
AU  - Lee,CF
DO  - 10.1371/journal.pone.0272587
EP  - 26
PY  - 2022///
SN  - 1932-6203
SP  - 1
TI  - Heterogeneous run-and-tumble motion accounts for transient non-Gaussian super-diffusion in haematopoietic multi-potent progenitor cells
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0272587
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272587
UR  - http://hdl.handle.net/10044/1/99575
VL  - 17
ER  -
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